Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2

BMC Pediatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 27, 2025

This study aims to explore the genetic characteristics of pediatric sepsis through a combined analysis multiple methods, including Mendelian Randomization (MR), differential gene expression analysis, and immune cell infiltration assessment. It explores their potential as biomarkers for risk involvement in immune-related pathways. Differential was performed using public datasets identify genes with significant changes between patients healthy controls. MR utilized genome-wide SNPs instrumental variables assess causal relationships risk. Bi-directional conducted both forward reverse causality. FDR correction applied adjust comparisons results. Immune investigate genes' roles responses, findings were validated independent datasets. ROC curves constructed predictive performance. identified RGL4,ATP9A,MAP3K7CL, DDX11L2. revealed associations these risk, RGL4 ATP9A upregulated (inflammatory roles), MAP3K7CL DDX11L2 downregulated (protective roles). found no showed key types, demonstrated strong potential. play important response regulation, offering insights into mechanisms that may inform future research treatment.

Язык: Английский

The combination of RL-QN15 and OH-CATH30 to promotes the repair of acne via the TLR2/NF-κB pathway

European Journal of Pharmacology, Год журнала: 2024, Номер unknown, С. 177233 - 177233

Опубликована: Дек. 1, 2024

Язык: Английский