Beyond antibiotics: mesenchymal stem cells and bacteriophages-new approaches to combat bacterial resistance in wound infections

Molecular Biology Reports, Год журнала: 2024, Номер 52(1)

Опубликована: Дек. 19, 2024

Язык: Английский

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Revolutionizing Coated Implants: Single-Step Approach Hydroxyapatite Featuring MoS2 Nanosheets Integration for anti-bacterial as well as anti-corrosive qualities

Corrosion Science, Год журнала: 2025, Номер unknown, С. 112771 - 112771

Опубликована: Фев. 1, 2025

Язык: Английский

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Skin regenerative potential of hydrogel matrices incorporated with stem cell-derived extracellular vesicles enriched with MicroRNAs: a systematic review

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Язык: Английский

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Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Март 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Язык: Английский

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Supermolecular poly-N-acryloyl glycinamide/polyglutamic acid/Fe3+ hydrogel incorporated with bioactive small extracellular vesicles promote diabetic wound healing by suppressing ferroptosis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142313 - 142313

Опубликована: Март 1, 2025

Язык: Английский

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Chitosan/poly (β‐amino ester) hydrogel by controlled release of Centella Asiatica promoted wound healing through improved collagen expression and antibacterial and anti‐inflammatory properties

Polymer Engineering and Science, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Abstract Burn wound healing presents several challenges, including impaired collagen synthesis, delayed closure, and disrupted inflammatory responses. This study investigates the potential of a novel UV‐crosslinked hydrogel made chitosan (CS)/poly(β‐amino ester) (PβAE) Centella Asiatica extract (CA) for second‐degree burn treatment. Among various formulations, monomer ratio 1.5:1 5 wt% 2,2‐dimethoxy‐2‐phenyl‐acetophenone DMPA crosslinker concentration were found optimal. The achieved ~74% controlled release CA over 72 h showed significant enhancement in fibroblast viability (123.66 ± 9% at days). Scratch assay demonstrated ~99.5% closure within 24 h. Collagen type I expression was increased by ~1.7‐fold compared with control. Additionally, exhibited remarkable anti‐inflammatory properties, effectively modulating response. It significantly reduced pro‐inflammatory markers such as IL‐6 TNF‐α while simultaneously enhancing levels cytokines, IL‐10 TGF‐β. dual action not only mitigates inflammation but also fosters regenerative environment, further supporting process promoting tissue recovery. antibacterial properties inhibition zones ~19.1 mm E. coli ~12.4 S. aureus . These results suggest that this biocompatible, biodegradable is promising therapeutic candidate wounds. Highlights Developed chitosan/PβAE burns. Optimized releases Boosts viability, migration, 1.7x. Reduces IL‐6, TNF‐α, IL‐10, Strong against aureus.

Язык: Английский

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Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration

International Communications in Heat and Mass Transfer, Год журнала: 2025, Номер 164, С. 108895 - 108895

Опубликована: Март 29, 2025

Язык: Английский

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Exosome‐Based Vaccines: Pioneering New Frontiers in Combating Infectious Diseases and Cancer

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Abstract Exosomes, small extracellular vesicles with lipid bilayer membranes, play a crucial role in cellular communication and can transfer diverse biological cargo, including proteins, lipids, nucleic acids, from donor to recipient cells. Exosomes possess immunological properties, such as antigen delivery immune activation, along excellent drug capabilities, making them promising candidates for vaccine development. For different diseases, exosome‐based vaccines be designed therapeutic or prophylactic by leveraging immunity humoral immunity. With the emergence of precision medicine, personalized demonstrate exceptional potential. This review systematically introduces sources, biogenesis mechanisms, components exosomes describes their regulatory roles system. Subsequently, preparation, administration, therapy are discussed. Finally, applications clinical trials fields anti‐infection anti‐tumor therapies particularly highlighted, an analysis potential challenges future

Язык: Английский

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Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation

Journal of Molecular Histology, Год журнала: 2025, Номер 56(2)

Опубликована: Апрель 1, 2025

Язык: Английский

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Advanced synthesis and biomedical applications of colloidal quantum dots: Innovations in Imaging, drug delivery, and theranostics

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114533 - 114533

Опубликована: Апрель 1, 2025

Язык: Английский

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