Recent Advances in the Application of Engineered Exosomes from Mesenchymal Stem Cells for Regenerative Medicine
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177236 - 177236
Опубликована: Янв. 1, 2025
Язык: Английский
Functional Nucleic Acid-Stabilized Selenium Nanotechnology Enable Synergistic Healing of Diabetic Chronic Wounds
Опубликована: Янв. 1, 2025
Язык: Английский
Microneedles in diabetic wound care: multifunctional solutions for enhanced healing
Burns & Trauma,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 1, 2025
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
Язык: Английский
Tβ4-Exosome-loaded Hemostatic and Antibacterial Hydrogel to Improve Vascular Regeneration and Modulate Macrophage Polarization for Diabetic Wound Treatment
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101585 - 101585
Опубликована: Фев. 18, 2025
Diabetic
wounds
often
exhibit
delayed
healing
due
to
compromised
vascular
function
and
intensified
inflammation.
In
this
study,
we
overexpressed
Thymosin
β4
(Tβ4)
in
Adipose-Derived
Stem
Cells
(ADSCs)
produce
Exosomes
(Exos)
rich
Tβ4.
We
then
utilized
a
dual
photopolymerizable
hydrogel
composed
of
Hyaluronic
Acid
Methacryloyl
(HAMA)
Poly-L-lysine
(PLMA)
for
the
sustained
release
Tβ4-Exos
on
diabetic
wounds.
The
results
showed
that
could
stimulate
angiogenesis
collagen
synthesis,
mitigate
inflammation
by
promoting
polarization
M1-type
macrophages
inhibiting
M2-type
macrophages.
Furthermore,
was
found
activate
PI3K/AKT/mTOR/HIF-1a
signaling
pathway,
thereby
enhancing
proliferation.
summary,
HAMA-PLMA
(HP)
management
through
upregulation
HIF-1a
pathway
modulation
macrophage
proliferation
significantly
accelerated
process
Язык: Английский
Advances of exosomes in diabetic wound healing
Burns & Trauma,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 1, 2025
Poor
wound
healing
is
a
refractory
process
that
places
an
enormous
medical
and
financial
burden
on
diabetic
patients.
Exosomes
have
recently
been
recognized
as
crucial
players
in
the
of
lesions.
They
excellent
stability,
homing
effects,
biocompatibility,
reduced
immunogenicity
novel
cell-free
therapies.
In
addition
to
transporting
cargos
target
cells
enhance
intercellular
communication,
exosomes
are
beneficial
nearly
every
phase
healing.
participate
modulating
inflammatory
response,
accelerating
proliferation
reepithelization,
increasing
angiogenesis,
regulating
extracellular
matrix
remodeling.
Accumulating
evidence
indicates
hydrogels
or
dressings
conjunction
with
can
prolong
duration
exosome
residency
wounds.
This
review
provides
overview
mechanisms,
delivery,
clinical
application,
engineering,
existing
challenges
use
repair.
We
also
propose
future
directions
for
biomaterials
incorporating
exosomes:
2D
3D
scaffolds,
loaded
healing-promoting
gases,
intelligent
biomaterials,
prospect
systematic
application
exosomes.
These
findings
may
might
shed
light
treatments
enlighten
some
studies
improve
quality
life
among
diabetes
Язык: Английский
Andrias davidianus Derived Glycosaminoglycans Direct Diabetic Wound Repair by Reprogramming Reparative Macrophage Glucolipid Metabolism
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Harnessing
cross‐species
regenerative
cues
to
direct
human
potential
is
increasingly
recognized
as
an
excellent
strategy
in
medicine,
particularly
for
addressing
the
challenges
of
impaired
wound
healing
aging
populations.
The
skin
mucus
Andrias
davidianus
plays
a
critical
role
self‐protection
and
tissue
repair,
yet
fundamental
factors
mechanisms
involved
remain
elusive.
Here,
this
work
presents
evidence
that
glycosaminoglycans
(GAGs)
derived
from
secretion
(SAGs)
serve
potent
mediators
angiogenesis
inflammatory
remodeling,
facilitating
efficient
diabetic
wounds.
Mechanistic
studies
reveal
SAGs
promote
macrophage
polarization
toward
anti‐inflammatory
pro‐regenerative
phenotype
(CD206
+
/Arg1
)
via
glucolipid
metabolic
reprogramming.
This
process
suppresses
excessive
inflammation
enhances
expression
VEGF
IL‐10
create
facilitative
microenvironment
regeneration.
Additionally,
develops
SAGs‐GelMA
composite
microspheres
address
multiple
stages
healing,
including
rapid
hemostasis,
exudate
control,
activation
endogenous
processes.
engineered
approach
significantly
improves
scarless
wounds
by
recruitment
reparative
macrophages.
findings
offer
new
insights
into
highlight
therapeutic
application
repair.
Язык: Английский
Advancing Osteoarthritis Treatment: The Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes and Biomaterial Integration
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2478 - 2478
Опубликована: Окт. 28, 2024
Background/Objectives:
Osteoarthritis
(OA)
is
a
prevalent
and
debilitating
joint
disorder
characterized
by
progressive
cartilage
degradation
inflammation,
for
which
traditional
treatments
offer
only
symptomatic
relief
without
halting
disease
progression.
Exosomes,
cell-free
vesicles
derived
from
mesenchymal
stem
cells,
have
emerged
as
promising
alternative
therapy
owing
to
their
regenerative
anti-inflammatory
properties.
Methods:
This
review
synthesizes
findings
recent
studies
(2017–2023)
on
the
therapeutic
potential
of
exosomes
in
OA
treatment,
highlighting
ability
modulate
microenvironment,
reduce
promote
repair
delivering
bioactive
molecules
such
cytokines,
growth
factors,
regulatory
ribonucleic
acids.
Results:
We
explore
integration
with
biomaterials,
hydrogels
scaffolds,
enhance
delivery
efficacy,
we
address
critical
challenges
associated
clinical
application,
including
standardization
isolation
characterization
methods,
scalability
production,
mechanistic
understanding,
long-term
safety.
Despite
these
challenges,
exosome-based
therapies
several
advantages
over
cell-based
treatments,
lower
immunogenicity,
ease
handling,
targeted
agents
damaged
tissues.
Conclusions:
provide
an
analytical
perspective
current
state
exosome
research
OA,
emphasizing
need
standardized
production
deeper
insights,
rigorous
safety
assessments.
Future
directions
should
focus
optimizing
systems,
exploring
personalized
medicine
approaches,
conducting
comparative
effectiveness
fully
realize
treatment.
Addressing
gaps
will
be
crucial
translating
bench
bedside
achieving
transformative
impact
management.
Язык: Английский