Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Biomedicines, Год журнала: 2022, Номер 10(7), С. 1686 - 1686

Опубликована: Июль 13, 2022

Naringin and naringenin are the main bioactive polyphenols in citrus fruits, consumption of which is beneficial for human health has been practiced since ancient times. Numerous studies have reported these substances' antioxidant antiandrogenic properties, as well their ability to protect from inflammation cancer, various vitro vivo experimental models animals humans. can suppress cancer development body parts, alleviating conditions patients by acting effective alternative supplementary remedies. Their anticancer activities pleiotropic, they modulate different cellular signaling pathways, cytokine growth factor production arrest cell cycle. In this narrative review, we discuss effects naringin on inflammation, apoptosis, proliferation, angiogenesis, metastasis invasion processes potential become innovative safe drugs.

Язык: Английский

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Citrus peel as a renewable bioresource: Transforming waste to food additives

Journal of Functional Foods, Год журнала: 2022, Номер 95, С. 105163 - 105163

Опубликована: Июнь 29, 2022

This review summarizes the potential use of citrus peels in food industry. The present work is an overview different compounds extracted from various species peel and functional properties compounds, along with their applications as valuable ingredients food-based products. Citrus a natural source diverse bioactive including polyphenols, pectins, proteins, pigments, dietary fibers, essential oils. These exhibit many biological activities, antioxidant, antimicrobial, anticancer, anti-inflammatory, antidiabetic activities. Thus, can be considered promising foods. It also utilized food-coloring, flavoring, thickening agent. waste generated processing industry form exhibits economic benefits by reentering line additive while providing sustainable innovative solutions to utilization.

Язык: Английский

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Phytochemicals in Cancer Treatment and Cancer Prevention—Review on Epidemiological Data and Clinical Trials

Nutrients, Год журнала: 2023, Номер 15(8), С. 1896 - 1896

Опубликована: Апрель 14, 2023

Phytochemicals are a non-nutritive substances that present in plants and contribute significantly to their flavor color. These biologically active compounds classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing alkaloids, known for potential health benefits the prevention of various diseases, including cancer. The purpose this review article is explore therapeutic dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, stilbenes, cancer treatment based on epidemiological studies clinical trials. Although majority report significant advantage heightened phytochemical consumption increased serum levels these linking exposure with lower risk across most types, effects could not be replicated available In fact, many trials were withdrawn early due lack evidence and/or harm. Despite strong anticancer effect well proven efficacy multiple studies, there still great need human trials, caution regarding safety measures. This provides an overview supporting chemopreventive properties focus further research area.

Язык: Английский

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Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

Molecules, Год журнала: 2020, Номер 25(23), С. 5545 - 5545

Опубликована: Ноя. 26, 2020

Phenolic compounds (quercetin, rutin, cyanidin, tangeretin, hesperetin, curcumin, resveratrol, etc.) are known to have health-promoting effects and they accepted as one of the main proposed nutraceutical group. However, their application is limited owing problems related with stability water solubility well low bioaccessibility bioavailability. These limitations can be overcome by encapsulating phenolic physical, physicochemical chemical encapsulation techniques. This review focuses on encapsulation, especially lipid-based techniques (emulsion/nanoemulsion, solid lipid nanoparticles, liposomes/nanoliposomes, etc.), digestibility characteristics in terms

Язык: Английский

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Green synthesis of silver nanoparticles using Citrus limon peels and evaluation of their antibacterial and cytotoxic properties

Saudi Journal of Biological Sciences, Год журнала: 2020, Номер 27(12), С. 3434 - 3441

Опубликована: Сен. 23, 2020

The present work aimed to synthesis silver nanoparticles (AgNPs) using biological waste products Citrus limon peels, its characterization, antimicrobial activities and the cytotoxic effect of synthesized green AgNPs. Characterization prepared AgNPs showed formation spherical, few agglomerated forms as measured by UV-visible spectrophotometer. average size was 59.74 nm DLS technique. spectrum observed at 3 KeV EDX. On other hand, FTIR analysis presence alcohols, phenolics, mono-substituted alkynes, aliphatic primary amines, sodium salt, amino acid, or SiOH alcohol groups. studies formed positive activity against most studied human pathogenic bacteria with varying degrees. Finally, evaluation were done two types cell lines, breast cancer line (MCF-7) colon carcinoma (HCT-116). results revealed concentration has a direct correlation viability. 50% inhibitory (IC50) MCF-7 in 23.5 ± 0.97 µL/100 µL, whereas HCT-116 37.48 5.93 µL.

Язык: Английский

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Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity

Frontiers in Pharmacology, Год журнала: 2021, Номер 11

Опубликована: Янв. 20, 2021

Sinensetin, a plant-derived polymethoxylated flavonoid found in Orthosiphon aristatus var. and several citrus fruits, has been to possess strong anticancer activities variety of other pharmacological benefits promising potency intended with minimal toxicity. This review aims compile an up-to-date reports published scientific information on sinensetin activities, mechanisms action The present findings about the compound are critically analyzed its prospect as lead molecule for drug discovery is highlighted. databases employed data collection mainly through Google Scholar, PubMed, Scopus Science Direct. In-vitro in-vivo studies showed that possessed wide range such anti-inflammatory, antioxidant, antimicrobial, anti-obesity, anti-dementia vasorelaxant activities. provided some insights cancer disease states. However, more detail mechanistic needed understand effects. More vivo various animal models including toxicity, pharmacokinetic, pharmacodynamic bioavailability required assess efficacy safety before submission clinical studies. In this review, insight serves useful resource thorough comprehensive understanding potential candidate discovery.

Язык: Английский

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Green Extraction Techniques for Obtaining Bioactive Compounds from Mandarin Peel (Citrus unshiu var. Kuno): Phytochemical Analysis and Process Optimization

Foods, Год журнала: 2021, Номер 10(5), С. 1043 - 1043

Опубликована: Май 11, 2021

In this study, an efficient utilization and valorization of mandarin peel (Citrus unshiu Marc. var. Kuno) was investigated using innovative green extraction techniques. The first step study included the analysis volatile compounds by performing a supercritical CO2 (SC-CO2) under different operating pressure conditions (100 300 bar). obtained extracts conducted gas chromatography-mass spectrometry (GC-MS), limonene found to be dominant component (13.16% at 100 bar; 30.65% After SC-CO2 treatment, exhausted citrus waste enriched with bioactive subjected subcritical water (SWE) in wide temperature range (130–220 °C) solvent-solid ratio (10–30 mL/g) time periods from 5 15 min, order obtain bioflavonoids. Identification quantification present bioflavonoids high-performance liquid chromatography diode array detector (HPLC), hesperidin (0.16–15.07 mg/g) determined as most abundant flavanon other polyphenolic that were possible by-products thermal degradation. At higher temperatures, presence 5-hydroxymethylfurfural (5-HMF) chlorogenic acid detected. Antiradical activity total phenolic content spectrophotometric methods, while process optimization performed response surface methodology (RSM).

Язык: Английский

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Antioxidant and Anti-Inflammatory Activity of Citrus Flavanones Mix and Its Stability after In Vitro Simulated Digestion

Antioxidants, Год журнала: 2021, Номер 10(2), С. 140 - 140

Опубликована: Янв. 20, 2021

Recently, several studies have highlighted the role of Citrus flavanones in counteracting oxidative stress and inflammatory response bowel diseases. The aim study was to identify most promising by a preliminary antioxidant anti-inflammatory screening vitro cell-free assays, then mix powerful ones equimolar ratio order investigate potential synergistic activity. obtained (FM) subjected simulated digestion evaluate availability parent compounds at intestinal level. Finally, activity investigated on Caco-2 cell-based model stimulated with interleukin (IL)-1β. FM showed stronger respect single flavanones, demonstrating occurrence LC-DAD-ESI-MS/MS analysis gastric duodenal digested (DFM) that all remained unchanged end digestion. As proof, superimposable behavior observed between DFM assay carried out cells. Indeed, it both decreased IL-6, IL-8, nitric oxide (NO) release similarly reference drug dexamethasone.

Язык: Английский

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A Novel Green Preparation of Ag/RGO Nanocomposites with Highly Effective Anticancer Performance

Polymers, Год журнала: 2021, Номер 13(19), С. 3350 - 3350

Опубликована: Сен. 30, 2021

The efficacy of current cancer therapies is limited due to several factors, including drug resistance and non-specific toxic effects. Due their tuneable properties, silver nanoparticles (Ag NPs) graphene derivative-based nanomaterials are now providing new hope treat with minimum side Here, we report a simple, inexpensive, eco-friendly protocol for the preparation silver-reduced oxide nanocomposites (Ag/RGO NCs) using orange peel extract. This work was planned curtail use chemicals, improve anticancer performance cytocompatibility Ag/RGO NCs. Aqueous extract peels abundant in phytochemicals that act as reducing stabilizing agents green synthesis Ag NPs NCs from nitrate (GO). Moreover, flavonoid present potent agent. Green-prepared were characterized by UV-visible spectrophotometry, transmission electron microscopy (TEM), scanning (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), dynamic light scattering (DLS). results study demonstrated killing potential against human breast (MCF7) lung (A549) cells two-fold pure NPs. normal epithelial (MCF10A) fibroblasts (IMR90) higher than mechanistic indicated induce toxicity through pro-oxidant reactive oxygen species generation antioxidant glutathione depletion provided novel highly effective better cytocompatibility.

Язык: Английский

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Formulation of Biscuits Fortified with a Flour Obtained from Bergamot By-Products (Citrus bergamia, Risso)

Foods, Год журнала: 2022, Номер 11(8), С. 1137 - 1137

Опубликована: Апрель 14, 2022

Bergamot belongs to the Rutaceae family and is a typical fruit grown principally in province of Reggio Calabria (South Italy). Nowadays, its industrial use mostly related extraction essential oil contained flavedo but also lesser extent juice (from pulp), which rich antioxidants. However, pressed pulp (known as Pastazzo) either used for animal feed or discarded. The aim this research was study effect bergamot Pastazzo flour shortbread biscuits. partially replaced 00 wheat different percentages (2.5%, 5%, 10% 15%). Simultaneously, sample without addition (control) analyzed, thus obtaining five biscuit samples. Cooking done ventilated oven at 180 °C. baking time control enriched samples depending on when desired color reached. took 12 min, while reached 8 min. All were subjected physicochemical antioxidant characterization, well total polyphenols flavonoids. resulted slight increase water activity humidity values. pH values decreased all compared control, more relevant with 10 15% from by-products. Hardness varied 1823 g (Control) 2022 2818 (respectively, 2.5% recipe). Total phenol content 0.14 mg GAE g−1 0.60 3.64 obtained results demonstrated that had positive influence content, increased added.

Язык: Английский

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