PUERTO MADERO EDITORIAL eBooks, Год журнала: 2023, Номер unknown
Опубликована: Июнь 15, 2023
Resumen: La informática biomédica centrada en el registro de información para emplearla casuísticas que no pudieron ser afrontadas debidamente y generan nuevos problemas por la constante evolución los malestares aquejan a seres vivos general requiere priorización situaciones
MMWR Morbidity and Mortality Weekly Report, Год журнала: 2024, Номер 73(15), С. 330 - 338
Опубликована: Апрель 18, 2024
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated vaccines.During December 19, 2021-October 29, 2023, Overcoming Network evaluated effectiveness (VE) ≥2 mRNA doses against hospitalization and critical illness among U.S. children adolescents aged 5-18 years, using a case-control design.Too few received bivalent or vaccines to separately evaluate their effectiveness.Most case-patients (persons positive test result) were unvaccinated, despite high frequency reported underlying conditions associated severe COVID-19.VE hospitalizations was 52% (95% CI = 33%-66%) when most recent dose administered <120 days before 19% 2%-32%) if interval 120-364 days.VE 31% 18%-43%) last any time within previous year.VE illness, defined as receipt noninvasive invasive mechanical ventilation, vasoactive infusions, extracorporeal membrane oxygenation, resulting death, 57% 21%-76%) 25% -9% 49%) it 38% 15%-55%) similar after excluding * These senior authors contributed equally this report.documented immunocompromising conditions.Because who waning doses, these data support CDC recommendations that all receive protect COVID-19.
Язык: Английский
Процитировано
7
Clinical Infectious Diseases, Год журнала: 2023, Номер 78(2), С. 338 - 348
Опубликована: Авг. 26, 2023
Abstract Background The epidemiology of coronavirus disease 2019 (COVID-19) continues to develop with emerging variants, expanding population-level immunity, and advances in clinical care. We describe changes the COVID-19 hospitalizations risk factors for critical outcomes over time. Methods included adults aged ≥18 years from 10 states hospitalized June 2021–March 2023. evaluated demographics, characteristics, (intensive care unit admission and/or death) (risk ratios [RRs]), stratified by vaccination status. Results A total 60 488 COVID-19–associated were analysis. Among those hospitalized, median age increased 75 years, proportion vaccinated 18.2% 70.1%, declined 24.8% 19.4% (all P < .001) between Delta (June–December, 2021) post-BA.4/BA.5 (September 2022–March 2023) periods. Hospitalization events had a higher ≥4 categories medical condition assessed (32.8%) compared all (23.0%). Critical outcome similar unvaccinated populations; presence was most strongly associated regardless vaccine status (unvaccinated: adjusted RR, 2.27 [95% confidence interval {CI}, 2.14–2.41]; vaccinated: 1.73 CI, 1.56–1.92]) across Conclusions who experienced decreased time, patient Multimorbidity outcomes.
Язык: Английский
Процитировано
15
Microbiology Spectrum, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
ABSTRACT Seroprevalence studies play an important role in estimating the number of children infected with SARS-CoV-2. We report SARS-CoV-2 seroprevalence seeking medical care for any reason at a free-standing pediatric hospital Seattle, WA over 2.5-year period and four distinct pandemic waves. randomly selected residual serum samples from young adults as inpatients outpatients Seattle Children’s Hospital between June 2020 December 2022 to test presence anti-nucleocapsid (N) antibodies. Samples were categorized into waves based on Washington State epidemiology: Wave 1 (June 2020–October 2020), 2 (November 2020–June 2021), 3 (July 2021–November 4 (December 2021–December 2022). Patient characteristics COVID-19 vaccine status obtained, zip codes used ascertain Social Vulnerability Index (SVI). Multivariable Poisson regression models robust variance estimates examine relationship patient anti-N-positivity each wave. Among 8,040 7,102 patients included analyses, rose 2.4% (95% CI, 2.0%–3.1%) 25.5% CI 23.3%–27.8%) (following Omicron surge). High SVI, Hispanic ethnicity, or use government insurance was associated increased anti-N positivity most observed steady increase followed by sharp after surge early 2022. Our data demonstrate burden specific groups health disparities within our region throughout pandemic. IMPORTANCE results highlight importance seropositivity essential tools provide information incidence prevalence seropositivity. also reinforce other reports demonstrating inequitable that this continued persist pandemic, even high adherence mitigation efforts. It highlights SVI’s value identifying communities must be part research, public vaccination strategies.
Язык: Английский
Процитировано
0
JAMA Network Open, Год журнала: 2025, Номер 8(4), С. e252841 - e252841
Опубликована: Апрель 1, 2025
In 2023, the first respiratory syncytial virus (RSV) vaccines were recommended for US adults 60 years or older, but few data are available about which patients most likely to receive vaccine inform future RSV outreach efforts. To assess patient- and community-level characteristics associated with receipt patient knowledge attitudes related disease vaccines. During season of use from October 1, April 30, 2024, older hospitalized RSV-negative acute illness enrolled in this cross-sectional study 26 hospitals 20 states. Sociodemographic clinical abstracted health records, structured interviews conducted Age, sex, race ethnicity, pulmonary disease, immunocompromised status, long-term care facility residence, medical insurance, social vulnerability index (SVI), educational level. The exposures identified a priori as possible factors entered into modified Poisson regression model accounting state clustering, association receipt. Knowledge summarized frequencies proportions. Among 6746 median age was 73 (IQR, 66-80) 3451 (51.2%) female. 6599 self-reported 699 (10.6%) Hispanic, 1288 (19.5%) non-Hispanic Black, 4299 (65.1%) White, 313 (4.7%) other ethnicity. There 700 RSV-vaccinated (10.4%) 6046 unvaccinated (89.6%) adults. 3219 who responded questions, 1519 (47.2%) had not heard unsure; 2525 3218 (78.5%) unsure if they eligible thought not. adjusted analyses, vaccination being 75 (adjusted risk ratio [ARR], 1.23; 95% CI, 1.10-1.38, P < .001), male (ARR, 1.15; 1.01-1.30; = .04), having 1.39; 1.16-1.67; status 1.30; 1.14-1.48; low 1.47; 1.18-1.83, .001) moderate 1.21-1.79; SVI, level consisting 4 more college 2.91; 2.14-3.96; at least some technical training 1.85; 1.35-2.53; grade 12 education General Educational Development 1.44; 1.03-2.00; .03). less among residents facilities, Medicaid coverage, uninsured patients. adults, eligibility low. Older those certain conditions have received vaccine, suggesting appropriate prioritization, sociodemographic differences uptake occurred.
Язык: Английский
Процитировано
0
CHEST Journal, Год журнала: 2024, Номер 166(1), С. 49 - 60
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
3
Open Forum Infectious Diseases, Год журнала: 2024, Номер 11(5)
Опубликована: Март 29, 2024
Abstract Background Respiratory syncytial virus (RSV) can cause hospitalization in young children and older adults. With vaccines monoclonal antibody prophylaxis increasingly available, identifying social factors associated with severe illnesses guide mitigation efforts. Methods Using data collected by the RSV Hospitalization Surveillance Network from 2016 to 2023, we identified hospitalizations Tennessee. We linked information (eg, patient demographic characteristics outcome) population-level variables vulnerability health care insurance coverage) publicly available sets using census tract of residence. incidence was calculated stratified period (2016–2020 2020–2023). modeled effect on Poisson regression. Results Among 2687 hospitalizations, there were 677 (25.2%) intensive unit admissions 38 (1.4%) deaths. The highest incidences occurred among aged <5 years adults ≥65 years: 272.8 per 100 000 person-years (95% CI, 258.6–287.0) 60.6 56.0–65.2), respectively. Having public higher as compared not having insurance: 60.5 57.6–63.4) vs 14.3 13.4–15.2). Higher residing a most socially vulnerable quartile least after adjusting for age, sex, (incidence rate ratio, 1.4; 95% 1.3–1.6). Conclusions living more tracts. Population measures might help strategies, including vaccine promotion provision reduce hospitalization.
Язык: Английский
Процитировано
2
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 24, 2024
Abstract Background Health has multiple dimensions influenced not only by individual factors but also broader social, economic, cultural, and political structures. The widespread COVID-19 pandemic multidimensional effects on people’s lives, which can have individuals’ lifestyles after the COVID-19. This study aimed to speculate social determinants of health during COVID-19, lead more effective planning for promoting community health. Methods present interviewed 21 experts in medical fields four months. sampling method was snowball. interviews were semi-structured administered in-person or electronic. All transcribed analyzed according Brown Clarke’s six-stage framework extract themes. Results participants 13 males, eight field, all had PhD, 17 academic members, 10 members Social Determinants Research Center. qualitative content analysis induced seven different themes that affect included: justice (3 Subcategories), integration (4 acceptance participation (2 adaptation flourishing cohesion Subcategories). Conclusions According study, a grand plan cover positive negative should at least dimensions. However, models do such comprehensiveness. Future studies may provide proper model be used clinical research fields.
Язык: Английский
Процитировано
1
Clinical Infectious Diseases, Год журнала: 2024, Номер 79(2), С. 305 - 311
Опубликована: Март 14, 2024
Abstract Background Growing evidence indicates antimicrobial resistance disproportionately affects individuals living in socially vulnerable areas. This study evaluated the association between CDC/ATSDR Social Vulnerability Index (SVI) and Streptococcus pneumoniae (SP) (AMR) United States. Methods Adult patients ≥18 years with 30-day nonduplicate SP isolates from ambulatory/hospital settings January 2011 to December 2022 zip codes of residence were across 177 facilities BD Insights Research Database. Isolates identified as AMR if they non-susceptible ≥1 antibiotic class (macrolide, tetracycline, extended-spectrum cephalosporins, or penicillin). Associations SVI score (overall themes) using generalized estimating equations repeated measurements within county account for within-cluster correlations. Results Of 8008 unique 574 US counties 39 states, overall proportion was 49.9%. A significant socioeconomic status (SES) theme detected higher SES (indicating greater social vulnerability) associated risk AMR. On average, a decile increase SES, indicating vulnerability, 1.28% increased (95% confidence interval [CI], .61%, 1.95%; P = .0002). household characteristic 0.81% CI, .13%, 1.49%; .0197). There no racial/ethnic minority status, housing type transportation theme, Conclusions characteristics themes most
Язык: Английский
Процитировано
1
PUERTO MADERO EDITORIAL eBooks, Год журнала: 2024, Номер unknown
Опубликована: Март 10, 2024
Resumen: La informática biomédica centrada en el registro de información para emplearla casuísticas que no pudieron ser afrontadas debidamente y generan nuevos problemas por la constante evolución los malestares aquejan a seres vivos general requiere priorización situaciones
Процитировано
0
Behavioral Sciences, Год журнала: 2024, Номер 14(10), С. 905 - 905
Опубликована: Окт. 8, 2024
COVID-19 vaccination is a critical public health measure to control the pandemic, but disparities in uptake remain concern. This study investigates determinants of among Korean adults using Andersen model. Data from 231,784 participants community survey were analyzed chi-square testing and logistic regression. The risk non-vaccination was higher those aged 19-64 (95% CI: 1.52-1.74), males 1.11-1.24), unemployed 2.21-2.47), unmarried individuals 1.12-1.24), with unmet healthcare needs 1.41-1.67), recipients national basic livelihood guarantees 1.45-1.73), lower subjective 1.20-1.30), depression 1.28-1.44), current smokers 1.13-1.30), skipping breakfast 1.04-1.16). Conversely, for less than high school education 0.72-0.81), psychological concerns about infection (0.87, 95% 0.82-0.92) or criticism (0.91, 0.86-0.97), chronic diseases 0.64-0.72), alcohol consumers 0.52-0.58). These findings underscore need targeted intervention strategies support systems promote vulnerable populations. Further research should explore long-term impact these interventions on uptake.
Язык: Английский
Процитировано
0