Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(10)
Опубликована: Окт. 11, 2024
Cardiovascular
disease
(CVD)
poses
a
major
health
burden
in
adults
with
chronic
kidney
(CKD).
While
cardiorespiratory
fitness,
race,
and
sex
are
known
to
influence
the
relationship
between
CVD
mortality
absence
of
disease,
their
roles
patients
CKD
remain
less
clear.
Therefore,
this
narrative
review
aims
synthesize
existing
data
on
specific
emphasis
sex.
It
highlights
that
both
traditional
non-traditional
risk
factors
contribute
development
population.
Additionally,
biological,
social,
cultural
determinants
racial
disparities
differences
outcomes
CKD.
Although
fitness
levels
also
differ
by
race
sex,
cardiovascular
is
consistent
across
these
groups.
Furthermore,
exercise
has
been
shown
improve
regardless
or
However,
effects
patients,
particularly
different
races
sexes
remains
poorly
understood
represent
critical
area
for
future
research.
Frontiers in Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 15, 2025
Chronic
kidney
disease
(CKD)
is
a
significant
global
health
issue,
often
linked
to
diabetes,
hypertension,
and
glomerulonephritis.
However,
aggregated
statistics
can
obscure
heterogeneity
across
subtypes,
age,
gender,
regions.
This
study
aimed
analyze
CKD
trends
from
1990
2021,
focusing
on
socio-demographic
index
(SDI),
regional
variations.
Data
were
extracted
the
Global
Burden
of
Disease
(GBD)
2021
database,
covering
prevalence,
incidence,
mortality,
disability-adjusted
life
years
(DALYs).
These
presented
as
counts
per
100,000
population
age-standardized
rates,
with
uncertainty
intervals
(UIs)
highlight
variability.
Joinpoint
regression
was
used
assess
over
30-year
period.
In
prevalence
359
million,
11.13
million
new
cases,
1.53
deaths,
44.45
DALYs-up
92,
156,
176,
114%
since
1990.
While
slightly
declined,
DALYs
increased
significantly.
burden
varied
by
region
notable
gender
disparities.
The
highlights
dramatic
rise
in
growth
aging,
emphasizing
need
for
targeted
treatment
effective
healthcare
policies.
Journal of Arrhythmia,
Год журнала:
2025,
Номер
41(1)
Опубликована: Янв. 10, 2025
Abstract
Background
Chronic
kidney
disease
(CKD)
increases
cardiac
arrest
(CA)
risk
because
of
renal
and
cardiovascular
interactions.
Methods
Using
Centers
for
Disease
Control
Prevention
(CDC)
data
from
1999
to
2020,
we
analyzed
CKD‐related
CA
mortality
the
impact
social
vulnerability
index
(SVI).
Results
We
identified
336
494
deaths,
with
stable
age‐adjusted
rates
over
time.
Disparities
were
observed
across
gender,
racial/ethnic,
geographic
subpopulations,
higher
among
males,
Hispanic
non‐Hispanic
Black
populations,
those
in
urban
Western
regions.
Higher
SVI
correlated
increased
mortality.
Conclusions
are
stable,
disparities
demographics;
correlates
mortality,
highlighting
needed
interventions.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8637 - 8637
Опубликована: Авг. 8, 2024
Premenopausal
women
generally
exhibit
lower
blood
pressure
and
a
prevalence
of
hypertension
than
men
the
same
age,
but
these
differences
reverse
postmenopause
due
to
estrogen
withdrawal.
Sexual
dimorphism
has
been
described
in
different
components
kidney
physiology
pathophysiology,
including
renin-angiotensin-aldosterone
system,
endothelin
tubular
transporters.
This
review
explores
sex-specific
function
regulation.
Understanding
provides
insights
into
potential
therapeutic
targets
for
managing
diseases,
considering
patient's
sex
hormonal
status.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(1), С. 224 - 224
Опубликована: Янв. 2, 2025
Background:
The
study
investigates
sex-related
differences
and
outcomes
in
unselected
patients
undergoing
invasive
coronary
angiography
(CA).
Sex-based
with
regard
to
baseline
characteristics
management
of
cardiovascular
disease
have
yet
been
demonstrated.
However,
their
impact
on
long-term
CA
remains
unknown.
Methods:
Consecutive
from
2016
2022
were
included
at
one
institution.
Prognosis
male
female
was
investigated
the
primary
endpoint
rehospitalization
for
heart
failure
(HF)
36
months.
Secondary
endpoints
comprised
risk
acute
myocardial
infarction
(AMI)
revascularization
months,
as
well
in-hospital
all-cause
mortality.
Statistical
analyses
Kaplan–Meier
analyses,
uni-
multivariable
Cox
proportional
regression
analyses.
Results:
From
2022,
7691
(males:
65.1%;
females:
34.9%).
Males
had
a
higher
prevalence
artery
(CAD)
(76.2%
vs.
57.4%;
p
=
0.001),
alongside
3-vessel
CAD
compared
females
(33.9%
20.3%;
0.001).
HF
months
males
(22.4%
0.036;
HR
1.127;
95%
CI:
1.014–1.254;
0.027),
which
no
longer
observed
after
adjustment.
Male
sex
associated
(9.6%
5.9%;
0.001;
1.659;
1.379–1.997;
still
evident
adjustment
(HR
1.650;
CI
1.341–2.029;
neither
AMI
(8.1%
6.9%;
0.077),
nor
mortality
(6.9%
6.5%;
0.689)
differed
significantly
between
two
sexes.
Conclusions:
In
consecutive
angiography,
independently
an
increased
revascularization,
but
not
HF-related
rehospitalization.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 19, 2025
Chronic
Kidney
Disease
(CKD)
is
associated
with
heightened
risk
of
thrombosis.
Prescription
anticoagulants
key
to
manage
it;
however,
CKD
patients
have
shown
an
increased
bleeding
under
anticoagulation
therapy
compared
non-CKD
patients.
We
hypothesized
that
the
sex
could
modify
metabolism
indoxyl
sulfate
(IS),
a
uremic
toxin
and
Apixaban.
Our
intoxication
model
shows
higher
doses
IS
apixaban
accumulate
in
plasma
female
mice
because
expression
differences
efflux
transporters
cytochromes
liver,
ileum
kidneys,
when
males.
Furthermore,
we
found
accumulation
females
contributes
bleeding.
Transcriptional
analysis
liver
samples
revealed
elevated
Sult1a1
but
reduced
Abcg2
Cyp3a11
mice,
while
kidneys
rates
Oat1
Oat3
were
respectively
lower
than
those
observed
males,
potentially
affecting
drug
clearance.
Whole
proteomics
confirmed
previous
transcriptional
results
at
protein
level
had
major
influence
regulating
both
coagulation
pathways.
Thus,
our
findings
underline
need
for
inclusive
clinical
preclinical
trials
accurately
reflect
sex-specific
metabolic
variations,
consider
CKD-specific
changes
optimize
dosing,
minimize
side
effects,
improve
patient
outcomes.
In
recent
years,
the
triglyceride-glucose
(TyG)
index
has
emerged
as
a
reliable
surrogate
marker
of
insulin
resistance
(IR).
This
study
aimed
to
investigate
association
between
TyG
and
severe
proteinuria
or
decreased
renal
function
in
patients
with
primary
membranous
nephropathy
(PMN).
We
consecutively
enrolled
536
PMN
hospitalized
at
Peking
University
Third
Hospital
from
January,
2014
December,
2023.
The
was
calculated
Ln[fasting
triglyceride
(mg/dL)×fasting
blood
glucose
(mg/dL)/2].
All
participants
were
categorized
into
quantiles
according
index.
Severe
defined
24
h
urine
protein
>
3.5
g/d,
estimated
glomerular
filtration
rate
<
90
mL/min/1.73m2.
Multivariable
logistic
regression,
restricted
cubic
spline
(RCS)
curves,
receiver
operating
characteristic
(ROC)
curves
used
for
analysis.
Among
PMN,
355
had
149
function.
levels
significantly
elevated
RCS
analysis
revealed
positive
linear
relationship
risk
(P
non-linear
=
0.317)
0.199)
PMN.
Using
lowest
quantile
reference,
multivariate-adjusted
regression
indicated
that
highest
increased
[odds
ratio
(OR)
2.08,
95%
confidence
interval
(CI):
1.44-3.01,
P
0.001]
(OR
1.57,
CI:
1.04-2.36,
0.032).
area
under
ROC
curve
(AUC)
is
0.613
(95%
0.564-0.662)
0.590
0.536-0.643)
Our
findings
correlation
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9940 - 9940
Опубликована: Сен. 14, 2024
Kidney
transplantation
significantly
improves
the
survival
of
patients
with
end-stage
kidney
disease
(ESKD)
compared
to
other
forms
replacement
therapy.
However,
transplant
recipients’
outcomes
are
not
fully
satisfactory
due
increased
risk
cardiovascular
diseases,
infections,
and
malignancies.
Immune-related
complications
remain
biggest
challenge
in
management
graft
recipients.
Despite
broad
spectrum
immunosuppressive
agents
available
more
detailed
methods
used
monitor
their
effectiveness,
chronic
allograft
nephropathy
remains
most
common
cause
rejection.
The
kynurenine
(KYN)
pathway
is
main
route
tryptophan
(Trp)
degradation,
resulting
production
a
plethora
substances
ambiguous
properties.
Conversion
Trp
KYN
by
enzyme
indoleamine
2,3-dioxygenase
(IDO)
rate-limiting
step
determining
formation
next
from
pathway.
IDO
activity,
as
well
subsequent
metabolites
pathway,
highly
dependent
on
balance
between
pro-
anti-inflammatory
conditions.
Moreover,
products
themselves
possess
immunomodulating
properties,
e.g.,
modify
activity
control
immune-related
processes.
were
widely
studied
neurological
disorders
but
recently
gained
attention
researchers
context
immune-mediated
diseases.
Evidence
that
this
degradation
may
represent
peripheral
tolerogenic
significant
implications
for
further
fueled
interest.
Our
review
aimed
present
recent
knowledge
about
role
pathogenesis,
diagnosis,
monitoring,
treatment
complications.
