Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside

Basic Research in Cardiology, Год журнала: 2023, Номер 118(1)

Опубликована: Фев. 7, 2023

Язык: Английский

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Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review

Molecules, Год журнала: 2023, Номер 28(4), С. 1861 - 1861

Опубликована: Фев. 16, 2023

Pharmacologists have been emphasizing and applying plant herbal-based treatments in vascular diseases for decades now. Olives, example, are a traditional symbol of the Mediterranean diet. Hydroxytyrosol is an olive-derived compound known its antioxidant cardioprotective effects. Acknowledging merit antioxidants maintaining endothelial function warrants application hydroxytyrosol dysfunction salvage recovery. Endothelial (ED) impairment cells that adversely affects homeostasis. Disturbance functioning precursor atherosclerosis and, subsequently, coronary peripheral artery disease. However, effects on were not extensively studied, limiting value either as nutraceutical supplement or clinical trials. The action at cellular molecular level gathered summarized this review. favorable improvement from vitro vivo studies scrutinized. We conclude capable to counteract oxidative stress, inflammation, aging, arterial stiffness; thus, it beneficial preserve both vivo. Although specifically dysfunction, safety efficacy had demonstrated via trials cardiovascular-related studies.

Язык: Английский

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Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1978 - 1978

Опубликована: Фев. 6, 2024

Endothelial cells line at the most inner layer of blood vessels. They act to control hemostasis, arterial tone/reactivity, wound healing, tissue oxygen, and nutrient supply. With age, endothelial become senescent, characterized by reduced regeneration capacity, inflammation, abnormal secretory profile. senescence represents one earliest features ageing contributes many age-related diseases. Compared those in arteries veins, microcirculation exhibit a greater extent heterogeneity. Microcirculatory leads declined capillary density, angiogenic potentials, decreased flow, impaired barrier properties, hypoperfusion or organ-dependent manner. The heterogeneous phenotypes microvascular particular vascular bed across different tissues remain largely unknown. Accordingly, mechanisms underlying macro- micro-vascular vary pathophysiological conditions, thus offering specific target(s) for therapeutic development senolytic drugs.

Язык: Английский

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Lifestyle factors as determinants of atherosclerotic cardiovascular health

Atherosclerosis, Год журнала: 2024, Номер 395, С. 117577 - 117577

Опубликована: Май 10, 2024

A sedentary lifestyle, low levels of physical activity and fitness, poor dietary patterns, psychosocial stress are strongly associated with increased morbidity mortality from atherosclerotic cardiovascular disease (ASCVD). Conversely, engaging in regular activity, maintaining optimal fitness levels, adhering to a heart-healthy pattern, effectively managing body weight, ensuring adequate sleep, implementing stress-reduction strategies, addressing risk factors reduced ASCVD. This comprehensive review synthesizes current evidence large observational studies randomized controlled trials on lifestyle as determinants ASCVD health. It also briefly reviews mechanistic insights into how such shear stress, reactive oxygen species production, chronic inflammation, platelets coagulation activation, endothelial dysfunction, sympathetic hyperactivity contribute the initiation exacerbation factors. These include obesity, hyperglycemia, type 2 diabetes, hypertension, dyslipidemia, subsequently leading development progression atherosclerosis, ultimately resulting or acute events. To bridge translational gap between epidemiologic trial-based clinical practice, practical recommendations summarized facilitate translation scientific knowledge actionable interventions promote Acknowledged is evidence-based adoption within healthcare systems, which remains crucial objective advancing health at population level.

Язык: Английский

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The interaction between particles and vascular endothelium in blood flow

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115216 - 115216

Опубликована: Фев. 21, 2024

Язык: Английский

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