Fungi, immunosenescence and cancer
Bin Xu,
Zan Luo,
Xing Niu
и другие.
Seminars in Cancer Biology,
Год журнала:
2025,
Номер
109, С. 67 - 82
Опубликована: Янв. 7, 2025
Язык: Английский
Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches
Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Inflammaging
refers
to
chronic,
low-grade
inflammation
that
becomes
more
common
with
age
and
plays
a
central
role
in
the
pathophysiology
of
various
vascular
diseases.
Key
inflammatory
mediators
involved
inflammaging
contribute
endothelial
dysfunction
accelerate
progression
atherosclerosis.
In
addition,
specific
pathological
mechanisms
inflammasomes
have
emerged
as
critical
drivers
immune
responses
within
vasculature.
A
comprehensive
understanding
these
processes
may
lead
innovative
treatment
strategies
could
significantly
improve
management
age-related
Emerging
therapeutic
approaches,
including
cytokine
inhibitors,
senolytics,
specialized
pro-resolving
mediators,
aim
counteract
restore
health.
This
review
seeks
provide
an
in-depth
exploration
molecular
pathways
underlying
highlight
potential
interventions.
Язык: Английский
Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 99 - 99
Опубликована: Янв. 16, 2025
Cellular
senescence
is
a
state
of
permanent
cell
cycle
arrest
accompanied
by
metabolic
activity
and
characteristic
phenotypic
changes.
This
process
crucial
for
developing
age-related
diseases,
where
excessive
calorie
intake
accelerates
dysfunction
aging.
Overnutrition
disturbs
key
pathways,
including
insulin/insulin-like
growth
factor
signaling
(IIS),
the
mammalian
target
rapamycin
(mTOR),
AMP-activated
protein
kinase.
The
dysregulation
these
pathways
contributes
to
insulin
resistance,
impaired
autophagy,
exacerbated
oxidative
stress,
mitochondrial
dysfunction,
further
enhancing
cellular
systemic
derangements.
On
other
hand,
dysfunctional
endothelial
cells
adipocytes
contribute
inflammation,
reduced
nitric
oxide
production,
altered
lipid
metabolism.
Numerous
factors,
extracellular
vesicles,
mediate
pathological
communication
between
vascular
system
adipose
tissue,
amplifying
imbalances.
Meanwhile,
caloric
restriction
(CR)
emerges
as
potent
intervention
counteract
overnutrition
effects,
improve
function,
reduce
restore
balance.
CR
modulates
such
IIS,
mTOR,
sirtuins,
glucose
metabolism,
reducing
promoting
autophagy.
can
extend
health
span
mitigate
diseases
delaying
improving
healthy
endothelial-adipocyte
interactions.
review
highlights
crosstalk
adipocytes,
emphasizing
potential
in
counteracting
overnutrition-induced
restoring
homeostasis.
Язык: Английский
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes
iScience,
Год журнала:
2024,
Номер
28(1), С. 111594 - 111594
Опубликована: Дек. 13, 2024
Язык: Английский
Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Дек. 28, 2024
Perivascular
adipose
tissue
(PVAT)
is
a
dynamic
that
affects
vascular
function
and
cardiovascular
health.
The
connection
between
PVAT,
the
immune
system,
obesity,
disease
complex
plays
pivotal
role
in
pathogenesis
of
diseases
such
as
atherosclerosis,
hypertension,
inflammation.
In
cardiometabolic
diseases,
PVAT
becomes
significant
source
proflammatory
adipokines,
leading
to
increased
infiltration
cells,
proinflammatory
promoting
smooth
muscle
cell
proliferation
migrationpromoting
migration.
This
exacerbates
dysfunction
by
impairing
endothelial
activation.
Dysregulated
also
contributes
hemodynamic
alterations
hypertension
through
enhanced
sympathetic
nervous
system
activity
impaired
vasodilatory
capacity
PVAT-derived
factors.
Therapeutic
interventions
targeting
key
components
this
interaction,
modulating
inflammation,
restoring
adipokine
balance,
attenuating
activation,
hold
promise
for
mitigating
obesity-related
complications.
Lifestyle
interventions,
pharmacological
agents
inflammatory
pathways,
surgical
approaches
aimed
at
reducing
mass
or
improving
are
potential
therapeutic
avenues
managing
associated
with
obesity
dysfunction.
Язык: Английский
Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome
The FASEB Journal,
Год журнала:
2024,
Номер
38(18)
Опубликована: Сен. 21, 2024
Abstract
One
in
six
people
are
projected
to
be
65
years
or
older
by
2050.
As
the
population
ages,
better
treatments
for
injuries
that
disproportionately
impact
aged
will
needed.
Clinical
studies
show
and
experience
higher
rates
of
morbidity
mortality
after
burn
injury,
including
a
greater
incidence
pulmonary
complications
when
compared
younger
injured
adults,
which
we
others
believe
is
mediated,
part,
inflammation
originating
intestines.
Herein,
use
our
clinically
relevant
model
scald
injury
young
mice
determine
whether
cohousing
with
giving
oral
gavage
fecal
material
from
sufficient
alter
microbiome
protect
them
ileum
lungs.
Aged
have
less
DNA
expression
Bacteroidetes
feces
an
unhealthy
Firmicutes/Bacteroidetes
ratio.
Both
ratio
these
two
phyla
restored
prior
month
but
not
transfer
mice.
This
shift
coincides
heightened
danger‐associated
molecular
patterns
(DAMP),
pro‐inflammatory
cytokine
interleukin‐6
(
il6
)
lung
aged,
mice,
antimicrobial
peptide
camp
lung.
Cohousing
reverses
DAMP
lung,
cathelicidin‐related
protein
while
DAMPs
reducing
also
increased
IL‐6
These
results
highlight
importance
intestinal
mediating
within
gut–lung
axis,
insights
into
potential
future
clinic.
Язык: Английский
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Дек. 3, 2024
Abstract
Background
Vasculopathy
underlies
diabetic
complications,
with
perivascular
adipose
tissue
(PVAT)
playing
crucial
roles
in
its
development.
However,
the
changes
cellular
composition
and
function
of
PVAT,
including
specific
cell
subsets
mechanisms
implicated
type
2
diabetes
mellitus
(T2DM)
vasculopathy,
remain
unclear.
Methods
To
address
above
issues,
we
performed
single-cell
RNA
sequencing
on
stromal
vascular
fraction
(SVF)
PVAT
from
normal
T2DM
rats.
Then,
various
bioinformatics
tools
functional
experiments
were
used
to
investigate
characteristic
profile
SVF,
their
implications,
underlying
mechanisms.
Results
Our
study
reveals
landscape
SVF
demonstrating
considerable
heterogeneity
significant
alterations
T2DM,
an
enhanced
inflammatory
response
elevated
proportions
macrophages
natural
killer
(NK)
cells.
Moreover,
are
critical
hubs
for
cross-talk
among
populations.
Notably,
identified
a
decreased
Pdpn
+
macrophage
subpopulation
rats
confirmed
this
mice
humans.
In
vitro
vivo
studies
demonstrated
that
alleviated
insulin
resistance
modulated
adipokine/cytokine
expression
adipocytes
via
Pla2g2d-DHA/EPA-GPR120
pathway.
This
subset
also
enhances
endothelial
smooth
muscle
cells,
inhibits
inflammation
oxidative
stress,
improves
vasodilatory
function,
thereby
protecting
blood
vessels.
Conclusion
exhibit
protective
effects
by
alleviating
modulating
adipocytes.
subtype
may
therefore
play
pivotal
mitigating
complications
T2DM.
findings
underscore
role
immune-metabolic
maintaining
homeostasis.
Graphical
Язык: Английский