Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors
Basic Research in Cardiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 17, 2024
Abstract
Immune
checkpoint
inhibitors
(ICIs)
have
revolutionized
cancer
therapy
by
unleashing
the
power
of
immune
system
against
malignant
cells.
However,
their
use
is
associated
with
a
spectrum
adverse
effects,
including
cardiovascular
complications,
which
can
pose
significant
clinical
challenges.
Several
mechanisms
contribute
to
toxicity
ICIs.
First,
dysregulation
checkpoints,
such
as
cytotoxic
T-lymphocyte-associated
protein
4
(CTLA-4)
and
programmed
cell
death
protein-1
(PD-1)
its
ligand
(PD-L1),
molecular
mimicry
cardiac
autoantigens,
leads
immune-related
events,
myocarditis
vasculitis.
These
events
result
from
aberrant
activation
T
cells
self-antigens
within
myocardium
or
vascular
endothelium.
Second,
disruption
homeostasis
ICIs
lead
autoimmune-mediated
inflammation
tissues,
manifesting
dysfunction
heart
failure,
arrhythmias,
pericarditis.
Furthermore,
upregulation
inflammatory
cytokines,
particularly
tumor
necrosis
factor-alpha,
interferon-γ,
interleukin-1β,
interleukin-6,
interleukin-17
contributes
endothelial
dysfunction,
plaque
destabilization,
thrombosis,
exacerbating
risk
on
long
term.
Understanding
intricate
side
effects
induced
crucial
for
optimizing
patient
care
ensure
safe
effective
integration
immunotherapy
into
broader
range
treatment
protocols.
The
implications
these
underscore
importance
vigilant
monitoring
early
detection
in
patients
receiving
Future
key
pathological
mediators
biomarkers
may
aid
prompt
diagnosis
cardiotoxicity
will
allow
timely
interventions.
Язык: Английский
Circadian biology of cardiac aging
Journal of Molecular and Cellular Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice
Atmosphere,
Год журнала:
2025,
Номер
16(1), С. 109 - 109
Опубликована: Янв. 19, 2025
Background:
Epidemiological
and
toxicological
studies
have
shown
that
inhalation
of
particulate
matter
(PM),
a
major
component
air
pollution,
is
associated
with
the
development
cardiovascular
diseases
(CVDs).
Cellular
senescence
other
aging
mechanisms
are
also
key
factors
in
progression
CVD.
This
study
aims
to
investigate
age-related
susceptibility
cardiac
remodeling
due
PM
exposure.
Methods:
Young
old
male
C57BL/6
mice
were
exposed
filtered
or
polluted
for
six
months
using
an
ambient
particle
concentrator.
Cardiac
hypertrophy,
fibrosis,
markers
cellular
(p53,
p21,
p-H2AX,
lipofuscin)
myocardium
evaluated
experimental
groups.
Results:
exposure
induces
signs
remodeling,
including
cardiomyocyte
enlargement
increased
young
mice,
along
elevated
p53
expression.
However,
no
significant
alterations
structure
observed
between
aged
not
PM.
Conclusions:
Our
indicates
younger
individuals
may
be
more
vulnerable
effects
chronic
than
older
later.
Further
needed
explore
detailed
this
age-dependent
response.
Язык: Английский
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Язык: Английский
Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
Aging Cell,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
ABSTRACT
The
lymphatic
vasculature
plays
essential
roles
in
fluid
balance,
immunity,
and
lipid
transport.
Chronic,
low‐grade
inflammation
peripheral
tissues
develops
when
structure
or
function
is
impaired,
as
observed
during
aging.
While
aging
has
been
associated
with
a
broad
range
of
heart
pathophysiology,
its
effect
on
cardiac
not
characterized.
Here,
we
analyzed
lymphatics
aged
20‐month‐old
mice
versus
young
2‐month‐old
mice.
Aged
hearts
showed
reduced
vascular
density,
more
dilated
vessels,
increased
fibrosis
peri‐lymphatic
zones.
As
exercise
shown
benefits
several
different
models
age‐related
disease,
further
investigated
the
effects
aerobic
training
lymphatics.
Eight
weeks
voluntary
wheel
running
attenuated
age‐associated
adverse
remodeling
lymphatics,
including
reversing
their
dilation,
increasing
lymph
vessel
density
branching,
reducing
perilymphatic
fibrosis.
Intravital
lymphangiography
demonstrated
improved
flow
after
training.
Our
findings
illustrate
that
leads
to
dysfunction,
can
improve
health
animals.
Язык: Английский
Impact of plant-derived antioxidants on heart aging: a mechanistic outlook
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Heart
aging
involves
a
complex
interplay
of
genetic
and
environmental
influences,
leading
to
gradual
deterioration
cardiovascular
integrity
function.
Age-related
physiological
changes,
including
ventricular
hypertrophy,
diastolic
dysfunction,
myocardial
fibrosis,
increased
arterial
stiffness,
endothelial
are
influenced
by
key
mechanisms
like
autophagy,
inflammation,
oxidative
stress.
This
review
aims
explore
the
therapeutic
potential
plant-derived
bioactive
antioxidants
in
mitigating
heart
aging.
These
compounds,
often
rich
polyphenols,
flavonoids,
other
phytochemicals,
exhibit
notable
antioxidant,
anti-inflammatory,
cardioprotective
properties.
substances
have
intricate
properties,
ability
scavenge
ROS,
enhance
endogenous
antioxidant
defenses,
regulate
signaling
pathways,
impede
fibrosis
inflammation-promoting
processes.
By
focusing
on
molecular
linked
cardiac
aging,
produced
from
plants
provide
significant
promise
reduce
age-related
decline
improve
general
health.
Through
comprehensive
analysis
preclinical
clinical
studies,
this
work
highlights
associated
with
promising
effects
antioxidants.
The
findings
may
helpful
for
researchers
identifying
specific
molecules
preventive
heart.
Язык: Английский
Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 545 - 545
Опубликована: Апрель 8, 2025
Aging
is
a
predominant
risk
factor
for
cardiovascular
diseases.
There
evidence
demonstrating
that
senescent
cells
not
only
play
significant
role
in
organism
aging
but
also
contribute
to
the
pathogenesis
of
diseases
younger
ages.
Encouraged
by
recent
findings
elimination
pharmacogenetic
tools
could
slow
down
and
even
reverse
animal
models,
senolytic
drugs
have
been
developed,
translation
results
from
basic
research
clinical
settings
has
initiated.
Because
numerous
studies
literature
show
beneficial
therapeutic
effects
targeting
cardiomyopathies
associated
with
ischemia/reperfusion
atherosclerotic
vascular
disease,
are
considered
next
generation
therapies
disorders.
However,
reported
controversial
or
detrimental
caused
approaches,
including
worsening
cardiac
dysfunction,
instability
plaques,
an
increase
mortality
which
challenges
therapy
into
practice.
This
brief
review
article
will
focus
on
(1)
analyzing
discussing
approaches
(2)
future
directions
questions
essential
understand
controversies
translate
preclinical
Язык: Английский