The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Язык: Английский
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion
Basic Research in Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Язык: Английский
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
Basic Research in Cardiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
A
long-standing
aim
in
the
setting
of
various
pathologies
including
acute
myocardial
infarction,
chronic
kidney
disease
(CKD),
and
ischaemic
stroke,
has
been
to
identify
successful
approaches
augment
cellular
organ
protection.
Although
continual
evolution
refinement
ideas
over
past
few
decades
allowed
field
progress,
we
are
yet
realise
clinical
translation
this
concept.
The
12th
Hatter
Cardiovascular
Workshop
identified
a
number
important
points
key
questions
for
future
research
relating
cardio-
neuro-protection
interorgan
communication.
Specific
topics
that
were
discussed
include
‘cardio-metabolic-renal’
axis
protection,
parasympathetic
signalling
hypothesis,
role
coronary
microvasculature
RISK
pathway
cardioprotection,
extracellular
vesicles
way
forward,
studies
remote
conditioning,
new
experimental
models
cardio-oncology
investigations.
Язык: Английский
A role for fibroblast and mural cell subsets in models of neuropathic pain.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Neuropathic
pain
is
a
particularly
intractable
type
of
chronic
that
can
result
from
physical
nerve
damage
due
to
surgery
or
entrapment.
Here,
we
present
data
which
suggest
particular
subclass
fibroblast
and
mural
cells
may
be
implicated
in
the
sensory
neuron
dysfunction
characteristic
this
state.
In
mouse
model
traumatic
painful
neuropathy,
used
RNA
sequencing,
cell
sorting
tissue
clearing
study
mesenchymal
lineage
cells.
We
show
Pdgfrb+
fibroblasts
are
increased
number
for
at
least
two
months
post-nerve
express
high
levels
known
putative
pro-algesic
mediators,
further
upregulated
neuropathy.
go
on
demonstrate
human
pericyte
line
releases
selection
these
mediators
protein
level.
Moreover,
conditioned
media
stimulated
pericytes
induces
intra-cellular
changes
induced
pluripotent
stem
derived
neurons;
(phosphorylation
transcription
factor
STAT3)
have
been
previously
linked
activation.
summary,
our
indicate
abnormalities
should
considered
when
developing
novel
strategies
tackle
neuropathic
pain.
Язык: Английский
Differentiation of MS lesions through analysis of microvascular distribution
Imaging Neuroscience,
Год журнала:
2024,
Номер
2, С. 1 - 16
Опубликована: Янв. 1, 2024
Abstract
Conventional
MRI
is
crucial
for
diagnosing
multiple
sclerosis
(MS)
but
lacks
precision,
leading
to
the
clinico-radiological
paradox
and
misdiagnosis
risk,
especially
when
confronted
with
unspecific
lesions
not
related
MS.
Advancements
in
perfusion-weighted
imaging
(PWI)
an
algorithm
designed
diseases
anticipated
contrast
agent
extravasation
offer
insight
into
microvascular
impairment
flow
heterogeneity.
Our
study
aimed
assess
these
factors
MS
patients
their
association
clinically
relevant
white
matter
injury
disease
course.
We
evaluated
60
adults
(WML),
including
50
diagnosed
or
syndromes
10
non-diseased
symptomatic
controls
(SC)
WML.
included
conventional
three-dimensional
(3D)
T2-weighted
fluid-attenuated
inversion
recovery
(T2-FLAIR),
3D
magnetization-prepared
two
rapid
acquisition
gradient-echo
(MP2RAGE),
post-contrast
T1-weighted
(T1)
images,
Dynamic
Susceptibility
Contrast
(DSC)
PWI
at
3T.
WML
masks
of
“unspecific
T2-FLAIR
lesions”,
“MS
T1-lesions”
were
manually
outlined
validated
by
a
neuroradiologist.
DSC-derived
parameters
analyzed
healthy-appearing
tissue.
showed
increased
heterogeneity
vasodilation
compared
SC,
as
well
within
group.
T1-lesions
exhibited
more
homogenized
flow.
findings
suggest
that
DSC-PWI,
combined
lesion
delineation,
can
provide
differentiation
from
WML,
highlighting
potential
pathology
previously
overlooked
Язык: Английский