Influence of Primary Neurologic Disease on Cardiovascular Health in Females

Circulation Research, Год журнала: 2025, Номер 136(6), С. 618 - 627

Опубликована: Март 13, 2025

Neurocardiology is an interdisciplinary field that examines the complex interactions between nervous and cardiovascular systems, exploring how neurological processes, such as autonomic system regulation brain-heart communication impact heart function contribute to health disease. Although much of focus on has centered traditional risk factors, influence system, especially in females, increasingly recognized a key determinant outcomes. This article reviews existing literature mechanisms females. Specifically, we analyze primary disorders including cerebrovascular disease, headache disorders, multiple sclerosis have specific downstream effects cardiac function. By understanding relationship health, this review highlights need for sex-specific approaches prevention, diagnosis, treatment disease ultimately encouraging discovery more effective care strategies improving

Язык: Английский

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Artificial Intelligence in Central-Peripheral Interaction Organ Crosstalk: The Future of Drug Discovery and Clinical Trials

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107734 - 107734

Опубликована: Апрель 1, 2025

Drug discovery before the 20th century often focused on single genes, molecules, cells, or organs, failing to capture complexity of biological systems. The emergence protein-protein interaction network studies in 2001 marked a turning point and promoted holistic approach that considers human body as an interconnected system. This is particularly evident study bidirectional interactions between central nervous system (CNS) peripheral which are critical for understanding health disease. Understanding these complex requires integrating multi-scale, heterogeneous data from molecular organ levels, encompassing both omics (e.g., genomics, proteomics, microbiomics) non-omics imaging, clinical phenotypes). Artificial intelligence (AI), multi-modal models, has demonstrated significant potential analyzing CNS-peripheral by processing vast, datasets. Specifically, AI facilitates identification biomarkers, prediction therapeutic targets, simulation drug effects multi-organ systems, thereby paving way novel strategies. review highlights AI's transformative role research, focusing its applications unraveling disease mechanisms, discovering optimizing trials through patient stratification adaptive trial design.

Язык: Английский

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The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways

Nature Reviews Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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Heart and brain interactions in heart failure: pathophysiological mechanisms and clinical perspectives

Heart Failure Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Cardiac biomarkers as predictors of cognitive decline in neurodegenerative conditions

Progress in brain research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Macrophage metabolic reprogramming: A trigger for cardiac damage in autoimmune diseases

Autoimmunity Reviews, Год журнала: 2024, Номер unknown, С. 103733 - 103733

Опубликована: Дек. 1, 2024

Язык: Английский

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