Prolonged atrial electromechanical delay and P-wave parameters in asymptomatic carotid artery stenosis: novel insights from a non-invasive evaluation

Journal of Medicine and Palliative Care, Год журнала: 2025, Номер 6(1), С. 20 - 26

Опубликована: Фев. 14, 2025

Aims: Stroke is one of the top three causes death in developed societies. Ischemic strokes are linked to carotid artery stenosis (CAS). Atrial fibrillation (AF) a commonly encountered clinical arrhythmia. It has been shown that prolongation intra- and interatrial conduction times, known as atrial electromechanical delay (EMD), associated with higher risk AF. We aimed determine correlation abnormalities between surface electrocardiographic TDI measurements CAS patient group. Methods: The study included 76 patients diagnosed extracranial internal (ICA) stenosis. Asymptomatic severe was defined 70-99% detected by digital subtraction angiography (DSA). longest P-wave time ACT were considered maximal duration. difference (Pmax) shortest (Pmin) accepted PD. (PD=Pmax-Pmin). EMD interval from onset electrical activity beginning mechanical contraction. Results: group had significantly longer Pmax PD values compared control (Pmax 104.72±6.03 93.06±7.26 ms, p

Язык: Английский

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Non-traditional risk factors and artificial intelligence in the management of atrial fibrillation

European Heart Journal, Год журнала: 2025, Номер 46(9), С. 771 - 774

Опубликована: Март 1, 2025

Язык: Английский

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Clonal Hematopoiesis of Indeterminate Potential and Atrial Fibrillation: Insights into Pathophysiology and Clinical Implications

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2739 - 2739

Опубликована: Март 18, 2025

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a novel risk factor for cardiovascular diseases. CHIP is characterized by the expansion hematopoietic stem cell clones harboring somatic mutations in genes such TET2, DNMT3A, and ASXL1, which are implicated inflammation, atrial remodeling, hypercoagulability. These foster pro-inflammatory pro-thrombotic environment conducive to arrhythmogenesis, thereby linking development progression fibrillation (AF). Mechanistic insights indicate that contributes fibrosis, disrupts calcium signaling, exacerbates oxidative stress, all heighten susceptibility AF. Clinical studies, including epidemiological Mendelian randomization analyses, further support association between an increased both incident progressive AF, with specific TET2 ASXL1 identified significant contributors. Additionally, been linked adverse outcomes elevated rates heart failure, thromboembolism, mortality. Understanding CHIP’s role AF pathophysiology offers opportunities precision medicine approaches, providing avenues early intervention targeted treatment. This review synthesizes current mechanistic clinical evidence on emphasizes its biomarker stratification, explores emerging therapeutic strategies targeting CHIP-associated pathways.

Язык: Английский

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The Search Continues for Better Markers That Aid in the Diagnosis and Prevention of Atrial Fibrillation and its Complications

Arquivos Brasileiros de Cardiologia, Год журнала: 2025, Номер 122(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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A Busca Continua por Melhores Marcadores que Auxiliem no Diagnóstico e na Prevenção da Fibrilação Atrial e suas Complicações

Arquivos Brasileiros de Cardiologia, Год журнала: 2025, Номер 122(1)

Опубликована: Янв. 1, 2025

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Learning from epidemiology: atrial fibrillation, peripheral artery disease, and twin pregnancy

European Heart Journal, Год журнала: 2025, Номер 46(13), С. 1173 - 1177

Опубликована: Апрель 1, 2025

Язык: Английский

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