Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer DOI Creative Commons
Emilie D. Duchesneau, Dae Hyun Kim, Til Stürmer‎

и другие.

JAMA Network Open, Год журнала: 2025, Номер 8(3), С. e250614 - e250614

Опубликована: Март 12, 2025

Importance Frailty assessed at a single time point is associated with mortality in older women breast cancer. Little known about how changes frailty following cancer treatment initiation affect mortality. Objective To evaluate the association between claims-based trajectories adjuvant chemotherapy and 5-year stage I to III Design, Setting, Participants This longitudinal cohort study used Surveillance, Epidemiology, End Results registries linked Medicare claims data (claims from 2003-2019). Women aged 65 years or diagnosed 2004 2017 were included. Eligible underwent surgery followed by as initial treatment. A landmark design was identify during year initiation. Continuous enrollment fee-for-service 180 days before diagnosis through 360 (landmark) required. who died disenrolled excluded. Analyses conducted September 2022 March 2024. Exposures Claims-based identified using Faurot index, validated proxy for based on demographics diagnosis, procedure, durable medical equipment claims. The index calculated every 30 (360 after initiation). trajectory clusters K-means clustering. Main Outcomes Measures Associations estimated Kaplan-Meier analysis. In total, 20 292 (median [IQR] age, 70 [67-74] years) identified. analysis resulted 6 clusters: 3 robust (16 120 [79.4%]) resilient (3259 [16.1%]) nonresilient (913 [4.5%]). Five-year higher belonging compared those (52.1% vs 20.3%; difference, 31.8%; 95% CI, 29.0%-36.2%). Conclusions Relevance this of cancer, long-term survival. Future research should assess interventions survival patient-centered outcomes population.

Язык: Английский

Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer DOI Creative Commons
Emilie D. Duchesneau, Dae Hyun Kim, Til Stürmer‎

и другие.

JAMA Network Open, Год журнала: 2025, Номер 8(3), С. e250614 - e250614

Опубликована: Март 12, 2025

Importance Frailty assessed at a single time point is associated with mortality in older women breast cancer. Little known about how changes frailty following cancer treatment initiation affect mortality. Objective To evaluate the association between claims-based trajectories adjuvant chemotherapy and 5-year stage I to III Design, Setting, Participants This longitudinal cohort study used Surveillance, Epidemiology, End Results registries linked Medicare claims data (claims from 2003-2019). Women aged 65 years or diagnosed 2004 2017 were included. Eligible underwent surgery followed by as initial treatment. A landmark design was identify during year initiation. Continuous enrollment fee-for-service 180 days before diagnosis through 360 (landmark) required. who died disenrolled excluded. Analyses conducted September 2022 March 2024. Exposures Claims-based identified using Faurot index, validated proxy for based on demographics diagnosis, procedure, durable medical equipment claims. The index calculated every 30 (360 after initiation). trajectory clusters K-means clustering. Main Outcomes Measures Associations estimated Kaplan-Meier analysis. In total, 20 292 (median [IQR] age, 70 [67-74] years) identified. analysis resulted 6 clusters: 3 robust (16 120 [79.4%]) resilient (3259 [16.1%]) nonresilient (913 [4.5%]). Five-year higher belonging compared those (52.1% vs 20.3%; difference, 31.8%; 95% CI, 29.0%-36.2%). Conclusions Relevance this of cancer, long-term survival. Future research should assess interventions survival patient-centered outcomes population.

Язык: Английский

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