Quinoa ameliorates polycystic ovary syndrome via regulating gut microbiota through PI3K/AKT/mTOR pathway and autophagy DOI Creative Commons

Jinfang Dou,

Yanxiang Wu, Rentong Hu

и другие.

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Окт. 11, 2024

Polycystic ovary syndrome (PCOS) is a unity of endocrine and metabolic disorders, associated with PI3K/AKT/mTOR, autophagy, gut microbiota. Quinoa valuable food source, which contains rich minerals, unsaturated fatty acids, has positive modulating effect on diseases. However, its effects potential mechanisms PCOS have not been reported yet. Therefore, the purpose this study to investigate quinoa rats by regulating Ten–week-old female Sprague-Dawley (SD) received letrozole for 24 days induction subsequently were treated diet 8 weeks. Vaginal smears used analyze estrous cycle rats. Hormone biochemical indexes analyzed kit assays glucometer. The pathological changes ovary, pancreas, duodenum colon observed HE staining. PI3K, AKT, mTOR autophagy-related proteins in measured western blot immunohistochemistry Tight junction 16 s rDNA sequencing was detect intestinal microbiota Network pharmacology molecular docking possible targets PCOS. Spearman correlation analysis relationship between microbial abundance hormone levels at phylum genus level. significantly improved parameters PCOS-like rats, state tissues. Especially, regulated expression ovary. may repair barrier upregulating tight colon, regulate factors colon. Additionally, increased Lactobacillu, Bacteroides Oscillospira, decreased Firmicutes/Bacteroidetes ratio Blautia, Prevotella, reversing dysregulation Correlation showed that there strong significant related Our result indicated maybe activation PI3K/AKT/mTOR signaling pathway, inhibition regulation flora.

Язык: Английский

Changes in the global burden of polycystic ovary syndrome from 1990 to 2021 DOI Creative Commons
Tong Lin,

Bingqin Xie,

Juan Yang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Abstract BACKGROUND Polycystic ovary syndrome (PCOS) is a chronic, multifaceted condition influenced by epigenetic and environmental factors that responsible for significant proportion of anovulatory infertility cases. Here, we analyzed the global, regional, national burdens PCOS from 1990 to 2021 using data Global Burden Disease (GBD 2021). METHODS Incidence, prevalence, Disability-Adjusted Life Years(DALYs) relevant 204 countries 21 territories were obtained GBD study. considered age-standardized rates (per 100,000 individuals) with 95% uncertainty intervals (95% UIs) aforementioned research presented trends based on age Socio-demographic Index (SDI) parameters. RESULTS incidence prevalence in reported at 30.7 867.7 per 100,000, respectively, revealing increases 26.77% 28.21%, since 1990. Additionally, disability-adjusted life years stood 7.6 globally 2021, marking 27.58% increase Age-standardized varied across countries, ranging 93.1 3978.9 cases women, Italy (3978.9), Japan (3104.7), New Zealand (2789.7) having highest rates. Notably, was noted peak among females 15–19 age. Regions high SDI exhibited (70.2), (1720.7), death (15.2) PCOS. Furthermore, nonlinear correlation between burden noted, peaking around an approximately 0.9. CONCLUSION Our findings highlight growing global impact underscore need concerted efforts attenuate increasing this condition. Significantly divergent disease observed different groups regions, regions bearing heavier burdens. The increased younger regional disparities urgency targeted intervention formulation policies effectively address public health issue.

Язык: Английский

Процитировано

0
Quinoa ameliorates polycystic ovary syndrome via regulating gut microbiota through PI3K/AKT/mTOR pathway and autophagy DOI Creative Commons

Jinfang Dou,

Yanxiang Wu, Rentong Hu

и другие.

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Окт. 11, 2024

Polycystic ovary syndrome (PCOS) is a unity of endocrine and metabolic disorders, associated with PI3K/AKT/mTOR, autophagy, gut microbiota. Quinoa valuable food source, which contains rich minerals, unsaturated fatty acids, has positive modulating effect on diseases. However, its effects potential mechanisms PCOS have not been reported yet. Therefore, the purpose this study to investigate quinoa rats by regulating Ten–week-old female Sprague-Dawley (SD) received letrozole for 24 days induction subsequently were treated diet 8 weeks. Vaginal smears used analyze estrous cycle rats. Hormone biochemical indexes analyzed kit assays glucometer. The pathological changes ovary, pancreas, duodenum colon observed HE staining. PI3K, AKT, mTOR autophagy-related proteins in measured western blot immunohistochemistry Tight junction 16 s rDNA sequencing was detect intestinal microbiota Network pharmacology molecular docking possible targets PCOS. Spearman correlation analysis relationship between microbial abundance hormone levels at phylum genus level. significantly improved parameters PCOS-like rats, state tissues. Especially, regulated expression ovary. may repair barrier upregulating tight colon, regulate factors colon. Additionally, increased Lactobacillu, Bacteroides Oscillospira, decreased Firmicutes/Bacteroidetes ratio Blautia, Prevotella, reversing dysregulation Correlation showed that there strong significant related Our result indicated maybe activation PI3K/AKT/mTOR signaling pathway, inhibition regulation flora.

Язык: Английский

Процитировано

0