Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast DOI Creative Commons
Patricia Kipkemoi, Jeanne E. Savage, Kevin J. Moore

и другие.

PLOS Global Public Health, Год журнала: 2025, Номер 5(5), С. e0003806 - e0003806

Опубликована: Май 30, 2025

Neurodevelopmental disorders (NDDs) are a group of conditions with their onset during the early developmental period and include such as autism intellectual disability. Occurrence NDDs is thought to be determined by both genetic environmental factors, but data on role factors for NDD in Africa limited. This study investigates influences children from Kenya. case-control compared typically developing two studies Kenyan coast. We included 172 participants Kilifi Autism 151 NeuroDev who had diagnosis at least one 112 73 no each study, respectively. Potential risk were identified using unadjusted univariable analysis adjusted multivariable logistic regression. Univariable sample revealed hypoxic-ischaemic encephalopathy conferred largest odds ratio (OR) 10.52 [95%CI: 4.04, 27.41] NDDs, followed medical complications pregnancy (gestational hypertension & diabetes, eclampsia, maternal bleeding) (OR=3.17 1.61, 6.23]). In sample, labour birth (OR=7.30 [95%CI 2.17, 24.61]), neonatal jaundice (OR=5.49 1.61,18.72]) infection (OR= 5.31 1.56, 18.11]) associated NDDs. analysis, seizures before age 3 years increased risk. Higher parity, child being older delivery home reduced Recognition important could guide preventative interventions, screening at-risk monitoring progress these children. Further examining aetiology population-based samples, including investigating interaction between needed.

Язык: Английский

Meta-correlation of Sperm Morphology and DNA Fragmentation Index DOI
Cennikon Pakpahan,

Natasha Susanto Utomo,

Markus Christian Hartanto

и другие.

Reproductive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health DOI Creative Commons
Aron Moazamian, Fabrice Saez, Joël R. Drevet

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 570 - 570

Опубликована: Май 9, 2025

Male-factor infertility accounts for nearly half of all cases, and mounting evidence points to oxidative stress as a pivotal driver sperm dysfunction, genetic instability, epigenetic dysregulation. In particular, the DNA lesion 8-hydroxy-2′-deoxyguanosine (8-OHdG) has emerged central mediator at interface damage regulation. We discuss how this can disrupt key mechanisms such methylation, histone modifications, small non-coding RNAs, thereby influencing fertilization outcomes, embryo development, offspring health. propose that interplay between reprogramming is further exacerbated by aging in both paternal maternal germlines, creating “perfect storm” increases risk heritable (epi)mutations. The consequences unresolved lesions thus persist beyond fertilization, contributing transgenerational health risks. Finally, we explore promise potential pitfalls antioxidant therapy strategy mitigate damage. While supplementation may hold significant therapeutic value men with subfertility experiencing elevated stress, careful, personalized approach essential avoid reductive unintended disruptions. Recognizing dual role shaping genome epigenome underscores need integrating redox biology into reproductive medicine, aim improving fertility treatments safeguarding future generations.

Язык: Английский

Процитировано

0
Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast DOI Creative Commons
Patricia Kipkemoi, Jeanne E. Savage, Kevin J. Moore

и другие.

PLOS Global Public Health, Год журнала: 2025, Номер 5(5), С. e0003806 - e0003806

Опубликована: Май 30, 2025

Neurodevelopmental disorders (NDDs) are a group of conditions with their onset during the early developmental period and include such as autism intellectual disability. Occurrence NDDs is thought to be determined by both genetic environmental factors, but data on role factors for NDD in Africa limited. This study investigates influences children from Kenya. case-control compared typically developing two studies Kenyan coast. We included 172 participants Kilifi Autism 151 NeuroDev who had diagnosis at least one 112 73 no each study, respectively. Potential risk were identified using unadjusted univariable analysis adjusted multivariable logistic regression. Univariable sample revealed hypoxic-ischaemic encephalopathy conferred largest odds ratio (OR) 10.52 [95%CI: 4.04, 27.41] NDDs, followed medical complications pregnancy (gestational hypertension & diabetes, eclampsia, maternal bleeding) (OR=3.17 1.61, 6.23]). In sample, labour birth (OR=7.30 [95%CI 2.17, 24.61]), neonatal jaundice (OR=5.49 1.61,18.72]) infection (OR= 5.31 1.56, 18.11]) associated NDDs. analysis, seizures before age 3 years increased risk. Higher parity, child being older delivery home reduced Recognition important could guide preventative interventions, screening at-risk monitoring progress these children. Further examining aetiology population-based samples, including investigating interaction between needed.

Язык: Английский

Процитировано

0