Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling Cascade DOI

Jawad Nadeem,

Rukhsana Sultana,

Amna Parveen

и другие.

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(3)

Опубликована: Фев. 26, 2025

ABSTRACT Aging is considered the contributory accumulation of abruptions occurring through cell signaling cascades, which ultimately cause changes in physical functions, fate, and damage across all organ systems. DNA response (DDR) also occurs telomere shortening, tumor formation, mitochondrial dysfunction, so forth. Cellular aging cycle arrest, result extended DDR cascade networks via MDC1, 53BP1, H2AX, ATM, ARF, P53, P13‐Akt, BRAF, Sirtuins, NAD + , These persistent arrests initiated by other associated stress‐induced signals promote a permanent state arrest called senescence‐associated secretory phenotype (SASP). However, cellular gets accelerated with faulty repair systems, produced senescent cells further generate various promoting contributors to age‐related dysfunctional diseases including SASP. Any these factors contribute disease development. Therefore, this review explores anti‐aging targeting SASP regulation their detailed networks. In addition, it allows researchers identify targets therapeutic strategies based on identified nonidentified targets.

Язык: Английский

Altered Energy Metabolism, Mitochondrial Dysfunction, and Redox Imbalance Influencing Reproductive Performance in Granulosa Cells and Oocyte During Aging DOI
Hiroshi Kobayashi,

Chiharu Yoshimoto,

Sho Matsubara

и другие.

Reproductive Sciences, Год журнала: 2023, Номер 31(4), С. 906 - 916

Опубликована: Ноя. 2, 2023

Язык: Английский

Процитировано

14
Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model DOI Creative Commons
Wendi Pei, Lin Fu,

Wenhuan Guo

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 3, 2024

Abstract Background Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years. However, efficacy and safety MSCs, as nonautologous components, remain to be further verified. Methods Two common sources umbilical cord-derived MSCs (UC-MSCs) adipose tissue-derived (AD-MSCs), were orthotopically transplanted into a mouse model ovarian evaluate their therapeutic effects. The treatment was evaluated, RNA sequencing performed explore underlying mechanisms involved. Results After orthotopic transplantation ovary, oestrous cycle, weight, number proportion primary follicles, granulosa proliferation, angiogenesis improved. effects AD-MSCs superior those UC-MSCs several indices, such post-transplant weight angiogenesis. Moreover, tumorigenesis, acute toxicity, immunogenicity biodistribution both found possess high profiles. Through analysis, enhancement MAPK cascade observed, long-term mainly linked activation immune function. Conclusions Orthotopic displays significant for mice.

Язык: Английский

Процитировано

5
Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence DOI Creative Commons
Weicheng Tang, Kaichen Wang, Yourong Feng

и другие.

Life Medicine, Год журнала: 2025, Номер 4(1)

Опубликована: Янв. 23, 2025

The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility dysfunction across multiple organs. Research has demonstrated cellular senescence various cell types within the trigger decline ovarian function through distinct stress responses, resulting aging. This review explores how may contribute to failure. Additionally, we discuss factors cause senescence, including accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, exposure chemotherapy. Furthermore, six types, oocytes, granulosa cells, theca immune surface epithelium, endothelial inside explore their contribution accelerated Lastly, describe potential senotherapeutics for treatment offer novel strategies longevity.

Язык: Английский

Процитировано

0
Investigating genetic links between biological aging and adverse pregnancy outcomes DOI
Ning Sun,

Kaiyan Yang,

Huihui Wang

и другие.

Biogerontology, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling Cascade DOI

Jawad Nadeem,

Rukhsana Sultana,

Amna Parveen

и другие.

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(3)

Опубликована: Фев. 26, 2025

ABSTRACT Aging is considered the contributory accumulation of abruptions occurring through cell signaling cascades, which ultimately cause changes in physical functions, fate, and damage across all organ systems. DNA response (DDR) also occurs telomere shortening, tumor formation, mitochondrial dysfunction, so forth. Cellular aging cycle arrest, result extended DDR cascade networks via MDC1, 53BP1, H2AX, ATM, ARF, P53, P13‐Akt, BRAF, Sirtuins, NAD + , These persistent arrests initiated by other associated stress‐induced signals promote a permanent state arrest called senescence‐associated secretory phenotype (SASP). However, cellular gets accelerated with faulty repair systems, produced senescent cells further generate various promoting contributors to age‐related dysfunctional diseases including SASP. Any these factors contribute disease development. Therefore, this review explores anti‐aging targeting SASP regulation their detailed networks. In addition, it allows researchers identify targets therapeutic strategies based on identified nonidentified targets.

Язык: Английский

Процитировано

0