Endometrial receptivity in women of advanced age: an underrated factor in infertility

Human Reproduction Update, Год журнала: 2023, Номер 29(6), С. 773 - 793

Опубликована: Июль 19, 2023

Abstract BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced is one of critical risk factors for female-related infertility. It well known that maternal positively correlates with deterioration oocyte quality and chromosomal abnormalities oocytes embryos. The effect on endometrial function may be equally important factor influencing implantation rate, pregnancy overall female fertility. However, there are only a few published studies this topic, suggesting area been under-explored. Improving our knowledge aging from biological (cellular, molecular, histological) clinical perspectives would broaden understanding risks age-related OBJECTIVE AND RATIONALE objective narrative review critically evaluate existing literature focus synthesizing evidence impact conception success. This provide insights into gaps application research findings promote development treatment options field. SEARCH METHODS was prepared using PubMed (Medline) until February 2023 keywords such as ‘endometrial aging’, ‘receptivity’, ‘decidualization’, ‘hormone’, ‘senescence’, ‘cellular’, ‘molecular’, ‘methylation’, ‘biological age’, ‘epigenetic’, ‘oocyte recipient’, donation’, ‘embryo transfer’, ‘pregnancy rate’. Articles language other than English were excluded. OUTCOMES In endometrium, alterations occur cellular, histological levels negative biology impair receptivity. Additionally, advanced influences cellular senescence, which plays role during initial phase major obstacle suitable senolytic agents aging. Aging also accountable chronic conditions associated inflammaging, eventually can lead increased pro-inflammation tissue fibrosis. Furthermore, epigenetic regulation thus altering relation between its chronological age. donation cycles determine receptivity respect rates implantation, pregnancy, miscarriage, live birth have revealed contradictory inferences indicating need future mechanisms corresponding causal effects women’s WIDER IMPLICATIONS Increasing infertility IVF failures. Based complied observations synthesized conclusions review, shown functioning. information recommendations focusing molecular composition, transcriptomic changes further prospective needed explore newly emerging therapeutic options, target without affecting decidualization. Moreover, trial protocols, cycles, beneficial direct implications outcomes.

Язык: Английский

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Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Фев. 14, 2025

Introduction Infertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with quality essential for successful implantation. Objective This systematic review meta-analysis aimed explore prevalence embryonic factors involved in implantation process, concentrating on following research inquiries: 1) rates euploid versus untested transfers; 2) efficiency transferring good embryos different age groups; 3) impact transfers gestational carriers; 4) donated gametes/embryos. The goal identify critical points improve therapies. Methods A comprehensive literature search identified 1474 relevant papers, 11 which met inclusion criteria. information was gathered using a standardized form, risk bias evaluated. subgroups determine conducted synthesize results. Furthermore, data extracted from registries document persistent secondary role extraembryonic determinants Results demonstrated that preimplantation genetic testing aneuploidy (PGT-A) significantly increased odds Age found influence factors, older women experiencing reduced as carriers. However, overall incidence low. highlights need focus PGT-A, diagnostic hysteroscopy, endometrial receptivity improving rates. Conclusion Implantation success ARTs largely depends euploidy. While achieving three greatly increases rates, it challenging women. Extraembryonic although present, have marginal impact. Subsequent studies ought concentrate modulating responses immunologically developing algorithms precision predicting success; well timing occurrence dormant phenomena also warrants further investigation.

Язык: Английский

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Omics-based novel strategies in the diagnosis of endometriosis

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2023, Номер 61(3), С. 205 - 225

Опубликована: Окт. 25, 2023

Endometriosis, an enigmatic and chronic disorder, is considered a debilitating condition despite being benign. Globally, this gynecologic disorder affects up to 10% of females reproductive age, impacting almost 190 million individuals. A variety genetic environmental factors are involved in endometriosis development, hence the pathophysiology etiology remain unclear. The uncertainty disease its complexity along with nonspecific symptoms have led misdiagnosis or lack diagnosis affected people. Biopsy laparoscopy referred as gold standard for diagnosis. However, invasiveness procedure, unnecessary operation disease-free women, dependence reliability on experience area most significant limitations. Therefore, continuous studies attempted offer noninvasive reliable approach. recent advances modern technologies generation large-scale biological data sets, known –omics data, resulting proceeding century biomedical sciences. Thereby, present study critically reviews novel biomarkers that based approaches from 2020 onward. findings reveal identified genomics, epigenomics, transcriptomics, proteomics, metabolomics potentially able diagnose endometriosis, predict prognosis, stage patients, potentially, near future, multi-panel these will generate clinical benefits.

Язык: Английский

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Equol Alleviates the In Vitro Aging‐Induced Disruption of Porcine Oocytes

Reproduction in Domestic Animals, Год журнала: 2025, Номер 60(1)

Опубликована: Янв. 1, 2025

ABSTRACT Oocyte quality is crucial for determining the subsequent embryo developmental capacity and reproductive outcomes. However, aging detrimental to oocyte quality. Previous studies have demonstrated that soy isoflavones positive effects on performance of female pigs. Equol, primary metabolite isoflavones, renowned its antioxidant properties ability scavenge reactive oxygen species (ROS). potential role equol in reversing aging‐mediated decline has not yet been elucidated. In this study, we treated porcine oocytes with different concentrations (2.5, 5 10 μM) during prolonged vitro culture. Our findings showed led decreased embryonic capacity, indicating We further found disrupted spindle assembly chromosome arrangement, impaired actin polymerisation reduced mitochondrial activity function. Moreover, increased ROS levels; thereafter, DNA damage apoptosis was induced oocytes. Interestingly, treatment 2.5 μM process significantly mitigated above‐mentioned defective parameters finally improved development rates. Collectively, these results imply benefits attenuating defects

Язык: Английский

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Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses

Reproductive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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Epigenetic clocks and female fertility timeline: A new approach to an old issue?

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Март 21, 2023

Worldwide increase in life expectancy has boosted research on aging. Overcoming the concept of chronological age, higher attention been addressed to biological which reflects a person's real health state, and may be resulting combination both intrinsic environmental factors. As epigenetics exert pivotal role aging, epigenetic clocks were developed. They are based mathematical models aimed at identifying DNA methylation patterns that can define age adopted for different clinical scopes (i.e., estimation risks developing age-related disorders or predicting lifespan). Recently, have gained peculiar fertility field, particular female counterpart. The insight into possible relations between aging women's infertility might glean additional information about certain conditions still not completely understood. Moreover, they could disclose significant implications promotion programs infertile women. Of relevance here is impact limited status but translate pregnancy issues. Indeed, alterations mother transfer offspring, itself as well related complications contribute modifications newborn. However, even if growing interest culminated conspicuous production studies these topics, global overview availability validated instruments diagnosis missing. present narrative review aims explore bonds timeline. In "infertility" section, we will discuss advances focusing tissues examined (endometrium, peripheral blood, ovaries). "pregnancy" results obtained from placenta, umbilical cord blood. mechanisms outcomes represents question configure clock bond two apparently opposite worlds: pregnancy.

Язык: Английский

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TET1 overexpression affects cell proliferation and apoptosis in aging ovaries

Journal of Assisted Reproduction and Genetics, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Язык: Английский

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Role of epigenetic regulation in diminished ovarian reserve

Journal of Assisted Reproduction and Genetics, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

Diminished ovarian reserve (DOR) is characterized by a decrease in the number and quality of oocytes, with its incidence increasing annually. Its pathogenesis remains unclear, making it one most challenging problems field assisted reproduction. Epigenetic modification, molecular mechanism affecting genomic activity expression without altering DNA sequence, has been widely studied reproductive medicine attracted considerable attention regarding DOR. This review comprehensively examines various epigenetic regulatory changes granulosa cells (OGCs) oocytes during methylation plays crucial role regulating cell function, hormone production, oocyte development, maturation, senescence. Histone modifications are involved follicular activation, while non-coding RNAs, such as long noncoding RNAs (lncRNAs) microRNAs (miRNAs), regulate function development. N6-methyladenosine (m6A) associated age-related clocks based on show potential predicting Furthermore, discusses for utilizing mechanisms to better diagnose manage

Язык: Английский

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Mediation Role of Telomere Length in the Relationship between Physical Activity and PhenoAge: A Population-based Study

Journal of Exercise Science & Fitness, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research. study encompassed cohort 6200 participants aged 20 years above, sourced from the National Health Nutrition Examination Survey (NHANES). Physical (PA) levels were assessed employing Global Activity Questionnaire, while DNA samples collected to determine measured base pairs. PhenoAge, an emerging index relying on nine distinct chemical biomarkers, was computed. Incorporating fully adjusted model, our analysis showed significant correlations PA engagement PhenoAge [Low PA, β (95 % CI): 0.039(-0.071,-0.008), p = 0.021; Moderate 0.058(-0.082,-0.034), < 0.001; High 0.069(-0.096,-0.042), 0.001]. Furthermore, positive link emerged elevated with CI) 0.011(0.001, 0.022), 0.034. A mediation performed, demonstrating that length mediated connection proportion calculated at 3.57 %. Our findings suggest may play key role mitigating processes by preserving highlighting potential as target for interventions aimed promoting healthy longevity.

Язык: Английский

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Bushen Jianpi Tiaoxue Decoction (BJTD) ameliorates oxidative stress and apoptosis induced by uterus ageing through activation of the SIRT1/NRF2 pathway

Phytomedicine, Год журнала: 2024, Номер 136, С. 156288 - 156288

Опубликована: Ноя. 25, 2024

Язык: Английский

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