Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies

Cells, Год журнала: 2024, Номер 13(16), С. 1354 - 1354

Опубликована: Авг. 14, 2024

Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.

Язык: Английский

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Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China

Environment International, Год журнала: 2025, Номер 196, С. 109321 - 109321

Опубликована: Фев. 1, 2025

Environmental factors, particularly various components of fine particulate matter (PM2.5) (i.e., sulfate [SO42-], nitrate [NO3-], ammonium [NH4+], organic [OM] and black carbon [BC]), are increasingly recognized as potential risk factors for poor ovarian response (POR) in fertility treatments. However, existing research is limited, the critical periods vulnerability to exposure PM2.5 its remain unclear. In this retrospective cohort study, we included 38,619 patients undergoing their first vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, defining POR primary outcome based on POSEIDON criteria. We divided six months prior oocyte pick up (OPU) into different windows used logistic regression models assess association between pollutants POR. Results showed that three before OPU significantly increased odds The distributed lag nonlinear model (DLNM) analysis revealed lagged effects component exposure, during weeks 2-5, where was associated with occurrence This period may represent a sensitive window exposure. Meanwhile, restricted cubic spline (RCS) indicated gradually higher pollutant concentrations. These findings underscore urgent need public health measures stages follicular development, policies aimed at reducing environmental among women reproductive age protect health.

Язык: Английский

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Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors

Biomarker Research, Год журнала: 2025, Номер 13(1)

Опубликована: Фев. 26, 2025

Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.

Язык: Английский

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Decoding the Molecular Landscape of Prepubertal Oocyte Maturation: GTPBP4 as a Key Driver of In Vitro Developmental Competence

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational medicine. In case prepubertal girls, clinical challenge is pronounced, as ovarian tissue cryopreservation‐though promising‐remains an experimental technique necessitating rigorous scientific validation to guarantee developmental potential preserved materials facilitate broader adoption. To address these knowledge gaps, while considering ethical implications, we applied transcriptome translatome sequencing comprehensively profile transcriptional dynamics in adult goats. Our analyses uncovered a sequential transition gene expression regulation, shifting from cytoplasmic processes chromosome segregation during process. Comparative profiling between goat oocytes revealed critical regulatory factors essential for maturation. These include genes involved organelle function ( GTPBP4 TOMM7 ), spindle organisation CKS2 , CCP110 CKAP5 ESCO1 ) CENPE CENPF CENPN SGO2 ). Functional through vitro experiments demonstrated that significantly enhances competence oocytes. This enhancement occurs promote cell cycle progression, mRNA translation. findings provide detailed map molecular events underpinning offer new perspectives on strategies required females. Translating insights humans, this research highlights fertility preservation such cryopreservation transplantation, follicle culture, meiotic artificial ovary technologies. Moreover, identified have significant implications improving reproductive efficiency breeding, bridging basic science.

Язык: Английский

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Efficacy and mechanism of Peony pods extract for treating premature ovarian failure: UPLC-Q-TOF/MS method combined with network pharmacology and experimental validation

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Peony pods, as a byproduct of peony seeds, are often discarded. This study aimed to explore the effect and mechanism pods extract (PPE) for treating premature ovarian failure (POF) by UPLC-Q-TOF/MS method combined with network pharmacology in vivo experimental validation. Firstly, total 26 components PPE were detected analysis. Subsequently, cisplatin was used construct POF model, treatment could significantly improve index, estrous cycle structure tissues, increase serum levels AMH estradiol E₂, reduce FSH LH in mice. Then, analysis performed found that multiple signaling pathways involved improving PPE, including PI3K/AKT, Ras Rap1 pathways. To further verification, related proteins WB, expression Bax, p-PI3K, p-AKT decreased, while Bcl-2, HO-1, Nrf-2 increased after administration. In summary, exert therapeutic on reducing cell apoptosis hormone levels, showing great potential application functional food.

Язык: Английский

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CCDC134 enhances ovarian reserve function and angiogenesis by directly interacting with INHA in a mouse model of premature ovarian insufficiency

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Association of Personal Care and Consumer Product Chemicals with Long-Term Amenorrhea: Insights into Serum Globulin and STAT3

Toxics, Год журнала: 2025, Номер 13(3), С. 187 - 187

Опубликована: Март 5, 2025

Chemicals in personal care and consumer products are suspected to disrupt endocrine function affect reproductive health. However, the link between mixed exposure long-term amenorrhea is not well understood. This study analyzed data from 684 women (2013–2018 National Health Nutrition Examination Survey) assess eight polyfluorinated alkyl substances (PFASs), 15 phthalates (PAEs), six phenols, four parabens. Various statistical models for robustness tests mediation analysis were used explore associations with role of serum globulin. Biological mechanisms identified through an integrated strategy involving target key chemicals intersections, pathway analysis, validation. Results showed that had higher levels Perfluorodecanoic acid, Perfluorohexane sulfonic acid (PFHxS), Perfluorononanoic n-perfluorooctanoic (n_PFOA), n-perfluorooctane Perfluoromethylheptane isomers. Logistic regression different adjustments consistently found significant elevated PFAS concentrations increased risk, confirmed by Partial Least Squares Discriminant Analysis. Mediation revealed globulin partially mediated relationship amenorrhea. Network suggested PFHxS n_PFOA may interact Signal Transducer Activator Transcription 3 (STAT3). highlights exposure, particularly n_PFOA, amenorrhea, STAT3 serving as mediators underlying mechanisms.

Язык: Английский

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The Role of Hypoxia-Inducible Factor-1α (HIF-1α) in the Progression of Ovarian Cancer: Perspectives on Female Infertility

Cells, Год журнала: 2025, Номер 14(6), С. 437 - 437

Опубликована: Март 14, 2025

Hypoxia-Inducible Factor-1α (HIF-1α) is crucial in the progression of ovarian cancer, especially influencing its tumor microenvironment and promoting pathogenic pathways that worsen female infertility. In hypoxic settings, HIF-1α stabilized activates transcription genes associated with angiogenesis, metabolic reprogramming, epithelial-to-mesenchymal transition, therapeutic resistance. Angiogenesis glycolytic reprogramming mediated by HIF-1 proliferation, survival, metastasis. Its dysfunction concurrently impairs homeostasis, undermining follicular growth, hormone synthesis, vascular network, consequently contributing to Moreover, induces persistent inflammation oxidative stress, an environment damaging reproductive health. Due dual function cancer growth infertility, a potential target. Strategies including small molecule inhibitors nanoparticle-mediated delivery drugs possess reduce activity, hence reducing while protecting fertility. This review seeks clarify molecular basis effects on providing insights into novel treatment approaches target both controlling disease preserving

Язык: Английский

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Evaluation of the Protective Effects of Alpha Lipoic Acid on Bleomycin‐Induced Ovarian Toxicity

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)

Опубликована: Март 21, 2025

Chemotherapeutic drugs administered during cancer therapy, may lead to the depletion of ovarian follicles, and subsequent infertility in fertile patients. We aimed determine toxic effects bleomycin (BLM) on rat ovary, evaluate protective alpha lipoic acid (ALA) BLM toxicity. The total 30 adult female rats were split into 4 groups. First, an intramuscular injection (i.m) (30 mg/m2) was + ALA groups except control 1st, 8th 15th days. group received 0.1 mL saline those (50 mg/kg) subcutaneously (s.c) for 2 weeks at same time with injections, s.c period. Ovarian tissues evaluated by histopathological, stereological, immunohistochemical (StAR, VDAC2, Caspase-3, Bcl-2, expression levels) ELISA (AMH serum methods. vascular areas collagen density increased medulla, volumes cortex, ovary group, whereas these changes decreased group. On other hand, VDAC2 Caspase-3 expressions decreased, StAR Bcl-2 increased, levels significantly Besides, follicle number AMH but remarkably established that have ameliorative harmful ovary.

Язык: Английский

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Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115442 - 115442

Опубликована: Апрель 1, 2025

Язык: Английский

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