Advances in pharmacology, Год журнала: 2024, Номер unknown, С. 1 - 83
Опубликована: Янв. 1, 2024
Язык: Английский
World Journal of Gastroenterology, Год журнала: 2025, Номер 31(6)
Опубликована: Янв. 10, 2025
Inflammatory bowel disease (IBD) is a global health burden that affects millions of individuals worldwide, necessitating extensive patient education. Large language models (LLMs) hold promise for addressing information needs. However, LLM use to deliver accurate and comprehensible IBD-related medical has yet be thoroughly investigated. To assess the utility three LLMs (ChatGPT-4.0, Claude-3-Opus, Gemini-1.5-Pro) as reference point patients with IBD. In this comparative study, two gastroenterology experts generated 15 questions reflected common concerns. These were used evaluate performance LLMs. The answers provided by each model independently assessed using Likert scale focusing on accuracy, comprehensibility, correlation. Simultaneously, invited comprehensibility their answers. Finally, readability assessment was performed. Overall, achieved satisfactory levels completeness when answering questions, although varies. All investigated demonstrated strengths in providing basic such IBD definition well its symptoms diagnostic methods. Nevertheless, dealing more complex advice, medication side effects, dietary adjustments, complication risks, quality inconsistent between Notably, Claude-3-Opus better than other models. have potential educational tools IBD; however, there are discrepancies Further optimization development specialized necessary ensure accuracy safety provided.
Язык: Английский
Процитировано
1
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 9, 2024
Abstract Background ERAP2 is an aminopeptidase involved in antigen processing and presentation, harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD). The lack of gene homologue mice has hampered functional studies, most human studies have focused on cells hematopoietic origin. Using IBD biobank vantage point, this study explores how variation affects expression human-derived epithelial organoids upon proinflammatory stimulation. Methods An patient cohort was genotyped with regards two single nucleotide polymorphisms (SNP) (rs2910686/rs2248374) associated levels, we examined the correlation between colon genotype, specifically aiming establish a relationship proficiency. Human-derived (colonoids) known genotype were established used explore differences whole genome ERAP2-deficient ( n = 4) -proficient donors pro-inflammatory encounter. Results When taking rs2910686 into account, upregulated inflamed patients. Colonoids upregulate IFNɣ stimulation, proficiency dependent genotype. Colonoid genotyping confirms that mechanisms independent frequently studied SNP rs2248374 can cause ERAP2-deficiency. A total 586 genes various molecular are differentially expressed proficient- deficient colonoids including encoding proteins following function: catalytic activity AOC1 , CPE ANPEP MEP1A ), regulator (TNFSF9 MDK GDF15 ILR6A LGALS3 FLNA transmembrane transporter (SLC40A1 SLC5A1 extracellular matrix structural constituents FGL2 HMCN2 MUC17 ). Conclusions mucosa, highly correlated rs2910686. While commonly determine expressional proficiency, our data lead deficiency. Our demonstrates presence response colonoids, suggesting pleiotropic role beyond MHC class I processing.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138237 - 138237
Опубликована: Ноя. 30, 2024
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2025, Номер 13(2), С. 480 - 480
Опубликована: Фев. 15, 2025
Background/Objectives: Ulcerative colitis (UC) and Crohn’s disease (CD) are the usual clinical forms of inflammatory bowel (IBD). Changes in oral microbiota, especially presence emerging fungi herpesviruses, have been shown to worsen aspects IBD. The aim this study was screen for pathogens yeast microbiota herpesvirus IBD patients. Methods: Oral swabs seven UC or CD patients were collected. samples plated on Sabouraud Dextrose Agar subcultured CHROMagar Candida Plus. Polyphasic taxonomy applied identified using molecular tools, such as MALDI-TOF MS ITS partial sequencing. Multiplex qPCR used identify herpesvirus. Results: mean age 38.67 ± 14.06 years, 57.14% female, two had diabetes. presented with Rhodotorula mucilaginosa, orthopsilosis Kodamaea jinghongensis, while Cutaneotrichosporon dermatis, glabrata, lusitanea tropicalis. Two individuals at least one In first individual, a co-detection Herpes Simplex Virus 1 (HSV-1) C. lusitaniae observed. second co-infections Epstein–Barr virus (EBV), Human Herpesvirus 7 (HHV-7) Conclusions: We rarely described yeasts patients, highlighting need they may contribute opportunistic infections.
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 5951 - 5967
Опубликована: Май 1, 2025
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the intestine, frequently complicated by intestinal fibrosis. As fibrosis progresses, it can result in luminal stricture and compromised function, significantly diminishing patients' quality life. Emerging evidence suggests that gut microbiota their metabolites contribute to pathogenesis IBD-associated influencing inflammation modulating immune responses. This review systematically explores mechanistic link between IBD evaluates therapeutic potential traditional Chinese medicine (TCM) interventions. Relevant studies were retrieved from PubMed, Web Science, Embase, Scopus, CNKI, Wanfang, VIP databases. Findings indicate TCM, including herbal prescriptions bioactive constituents, modulate composition microbial metabolites, ultimately alleviating through anti-inflammatory, immunemodulatory, anti-fibrotic mechanisms. These insights highlight TCM as promising strategy for targeting management
Язык: Английский
Процитировано
0
Current Research in Pharmacology and Drug Discovery, Год журнала: 2025, Номер unknown, С. 100223 - 100223
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Current Opinion in Gastroenterology, Год журнала: 2025, Номер unknown
Опубликована: Май 2, 2025
Purpose of review This explores the evolving landscape inflammatory bowel disease (IBD) therapy, particularly through lens startups that are pushing boundaries current treatment paradigms. By discussing challenges and opportunities faced by startups, this seeks to provide insights for aspiring entrepreneurs innovators in IBD space. Recent findings The is rapidly evolving, with innovative solutions ranging from novel therapeutics digital health platforms. An analysis recent SBIR award winners highlights emerging trends, including microbiome-based therapies, targeted small molecules, advanced drug delivery systems like hydrogels. Digital solutions, such as smart monitoring tools AI-assisted selection gaining traction. playing a crucial role cost reduction competition, streamlining development, personalization. Despite regulatory, financial, funding challenges, driving next phase innovation. Summary future therapy being driven start-ups challenging status quo treatment. These companies addressing critical gaps focusing on targets, improved delivery, precision medicine. While face many high research development (R&D) costs, regulatory hurdles, funding, they continue be at forefront Their success could potentially lead more affordable effective therapies. drawing examples nutraceutical company, Evinature, my own personal experience technical Edulis, startup focused localized perspective head Crohn's Colitis Foundation's Ventures, aims those looking innovate IBD.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(11), С. 825 - 825
Опубликована: Июнь 2, 2025
Inflammatory bowel disease (IBD), including Crohn’s and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract with rising incidence an unclear etiology. Innate lymphoid cells (ILCs) have recently emerged as key regulators mucosal immunity tissue homeostasis are increasingly implicated in IBD. Unlike adaptive lymphocytes, ILCs do not require antigen recognition clonal expansion to respond rapidly environmental cues shape immune responses. In healthy gut, maintain intestinal by guarding epithelial barrier, protecting against pathogens, mounting proper responses external insults. However, their altered differentiation, proliferation, recruitment, activation, interaction other host cells, microbiota, stimuli may contribute this review, we discuss recent advances understanding murine human context inflammation A deeper ILC-mediated mechanisms offer novel therapeutic strategies for restoring improving personalized management
Язык: Английский
Процитировано
0
Advances in pharmacology, Год журнала: 2024, Номер unknown, С. 1 - 83
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2