Klebsiella pneumoniae infection increases risk of Alzheimer's disease in the UK Biobank cohort

Psychogeriatrics, Год журнала: 2025, Номер 25(2)

Опубликована: Фев. 22, 2025

Abstract Background Infections, including bacterial pathogens, have been implicated in Alzheimer's disease (AD) risk. Klebsiella pneumoniae ( K. ) is a common hospital‐acquired pathogen associated with significant inflammation, which may contribute to neurodegeneration. This study investigates the relationship between infections and AD UK Biobank cohort. Methods Using data, we assessed diagnoses based on linked healthcare records identified using International Classification of Disease 10 th Edition codes B96.1 J15.0. A cohort 502 494 participants was analyzed for incidence relation demographic factors, educational years, apolipoprotein E (APOE) isoforms, history infection. Logistic regression used assess association infection Results significantly higher among (1.0%) compared those without (0.2%; P < 0.001, Fisher's exact test two‐tailed). analysis revealed that an increased risk (odds ratio = 3.32, 0.001), independent age, sex, education, APOE isoform. Additionally, ε4ε4 carriers age but decreased additional years education. Conclusion Our findings suggest be factor AD. underscores need further research into control its role mitigating neurodegenerative risk, particularly populations susceptible healthcare‐associated infections.

Язык: Английский

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Antibiotics-induced dysbiosis impacts dendritic morphology of adult mouse cortical interneurons

Frontiers in Neuroanatomy, Год журнала: 2025, Номер 19

Опубликована: Март 7, 2025

Introduction A growing body of evidence suggests that the gut microbiome may contribute to changes in brain morphology. The microbiota-gut-brain axis (MGBA) has been shown influence neurogenesis, axon myelination, and synapse structure. However, it remains unclear whether MGBA can morphology density inhibitory GABAergic interneurons. aim this study was determine antibiotic-induced dysbiosis (AID) is associated with alterations dendritic interneurons medial entorhinal cortex (mEC), somatosensory (SSC), motor (MC), hippocampus (Hp). Methods cohort six-month-old GAD-67-EGFP transgenic mice treated an antibiotic cocktail for two weeks, resulting as validated by collecting stool samples at baseline after treatment, then using next-generation sequencing 16S ribosomal RNA. Results results demonstrate proposed model effectively exhibited defining features dysbiosis, including a significant reduction diversity, expansion pathobionts, loss beneficial microbes. AID group showed different areas. mean length segments SSC Hp were found be significantly decreased, while no such decrease observed mEC or MC. Furthermore, decreased mEC, Hp, areas, change MC area. Discussion interneuron dysfunction plays role pathogenesis neurological disease. findings suggest potentially influences interneurons, which development disorders.

Язык: Английский

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Common microbial signatures in blood and their amplification in clinical disorders

Gut Microbes Reports, Год журнала: 2025, Номер 2(1), С. 1 - 19

Опубликована: Март 19, 2025

Язык: Английский

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Klebsiella pneumoniae infection increases risk of Alzheimer Disease in the UK Biobank cohort

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Infections, including bacterial pathogens, have been implicated in Alzheimer's disease (AD) risk. Klebsiella pneumoniae (K. pneumoniae) is a common hospital-acquired pathogen associated with significant inflammation, which may contribute to neurodegeneration. This study investigates the relationship between K. infections and AD UK Biobank cohort.

Язык: Английский

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