Blood flow‐induced angiocrine signals promote organ growth and regeneration DOI Creative Commons

Paula Follert,

Linda Große‐Segerath, Linda Große‐Segerath

и другие.

BioEssays, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Recently, we identified myeloid-derived growth factor (MYDGF) as a blood flow-induced angiocrine signal that promotes human and mouse hepatocyte proliferation survival. Here, review literature reporting changes in flow after partial organ resection the liver, lung, kidney, describe signals released by endothelial cells (ECs) upon alterations these organs. While (HGF) MYDGF are important for liver regeneration, now, have also been reported to stimulate hyperplasia and/or hypertrophy during regeneration of lungs kidneys. In addition, play critical role tumor growth. Understanding mechano-elastic properties flow-mediated organ-specific microvasculature is crucial therapeutic approaches maintain health initiate renewal.

Язык: Английский

Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures DOI Creative Commons
Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Alyssa Shapiro

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Surface modification of polydimethylsiloxane (PDMS) for organ-on-a-chip (OOC) systems is fundamental the success cell physiological assays. Although UV light commonly used this purpose, surface chemical modifications are only temporary. To overcome these limitations, an alternative approach proposed: a physicochemical using ozone and heterofunctional crosslinker sulfo-SANPAH (SS). This simple one-step carried out on PDMS microchannels OOC platforms. A broad characterization based spectroscopy microscopy techniques confirms successful surface. The contact angle decreases after addition SS (from 101.4° to 79.9°) but as low 20.8° extracellular matrix deposition, demonstrating transition from hydrophobic hydrophilic. For biological characterization, human liver sinusoidal endothelial cells (LSEC) murine primary hepatocytes cultured in channels up 7 days. LSECs establish strong adhesions under laminar flow form well-established canaliculi network, respectively. method simpler than others reported literature (e.g., 3-aminopropyltriethoxysilane) ideal beginners interested microfluidic platforms culture.

Язык: Английский

Процитировано

0
Blood flow‐induced angiocrine signals promote organ growth and regeneration DOI Creative Commons

Paula Follert,

Linda Große‐Segerath, Linda Große‐Segerath

и другие.

BioEssays, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Recently, we identified myeloid-derived growth factor (MYDGF) as a blood flow-induced angiocrine signal that promotes human and mouse hepatocyte proliferation survival. Here, review literature reporting changes in flow after partial organ resection the liver, lung, kidney, describe signals released by endothelial cells (ECs) upon alterations these organs. While (HGF) MYDGF are important for liver regeneration, now, have also been reported to stimulate hyperplasia and/or hypertrophy during regeneration of lungs kidneys. In addition, play critical role tumor growth. Understanding mechano-elastic properties flow-mediated organ-specific microvasculature is crucial therapeutic approaches maintain health initiate renewal.

Язык: Английский

Процитировано

1