A variant centric analysis of allele sharing in dogs and wolves

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Abstract Canines are an important model system for genetics and evolution. Recent advances in sequencing technologies have enabled the creation of large databases genetic variation canines, but analysis allele sharing among canine groups has been limited. We applied GeoVar, approach originally developed to study single nucleotide polymorphisms across human populations, assess wolves, village dogs, breed dogs. Our shows that wolves differ from each other at average approximately 2.3 million sites while dogs same nearly 1 sites. find 22% variants common ∼16% variable half differences between two different breeds due all clades. These analyses represent a succinct summary canines illustrate effects history on apportionment variation.

Язык: Английский

A Variant-Centric Analysis of Allele Sharing in Dogs and Wolves

Genes, Год журнала: 2024, Номер 15(9), С. 1168 - 1168

Опубликована: Сен. 5, 2024

Canines are an important model system for genetics and evolution. Recent advances in sequencing technologies have enabled the creation of large databases genetic variation canines, but analyses allele sharing among canine groups been limited. We applied GeoVar, approach originally developed to study single nucleotide polymorphisms across human populations, assess wolves, village dogs, breed dogs. Our analysis shows that wolves differ from each other at average approximately 2.3 million sites while dogs same nearly 1 sites. found 22% variants common ~16% variable half differences between two different breeds due all clades. These represent a succinct summary canines illustrate effects history on apportionment variation.

Язык: Английский

Characterization of Nuclear Mitochondrial Insertions in Canine Genome Assemblies

Genes, Год журнала: 2024, Номер 15(10), С. 1318 - 1318

Опубликована: Окт. 14, 2024

The presence of mitochondrial sequences in the nuclear genome (Numts) confounds analyses sequence variation, and is a potential source false positives disease studies. To improve analysis variation canines, we completed systematic assessment Numt content across assemblies, canine populations carnivore lineage.

Язык: Английский