Evolution of CEACAM pathogen decoy receptors in primates DOI Creative Commons
Wolfgang Zimmermann, Robert Kammerer

European Journal of Clinical Investigation, Год журнала: 2024, Номер 54(S2)

Опубликована: Дек. 1, 2024

Abstract Background CEACAM1 in leukocytes controls cell activation during inflammation. This and its expression epithelial cells led to frequent independent appropriation of as receptor by pathogens humans other species gain host access downregulate immune response. As a countermeasure, decoy receptors with CEACAM1‐like pathogen‐binding domains evolved. The granulocyte‐specific human CEACAM3 endocytic diverts CEACAM1‐binding neutrophils for internalization destruction. role the glycosylphosphatidylinositol‐anchored CEACAM5 CEACAM6 which can also bind CEACAM1‐targeting is less clear. Methods We analyzed selection CEACAMs avoid pathogen binding maintain similarity between 148 primate species. Results Notably, functional genes were not found gibbons New World monkeys. Interestingly, these primates exhibits similar high ratios rates nonsynonymous synonymous substitution (dN/dS) their N domain exons . High dN/dS are indicative diversification typically seen receptors. Human expressed on granulocytes cells. Therefore, could substitute missing CEACAM3. In nearly all investigated groups epithelially exhibit diversification. African populations, five high‐frequency polymorphisms observed region (I80V, V83A, I100T, I112V, I113T) 3‐4 combined same individual. These correspond sequences. Conclusion under most species, indicating function

Язык: Английский

Population genetic structure of Uroteuthis edulis in the East China Sea based on the COI gene DOI
Zixuan Yang,

Feifei Wu,

Zhou Fang

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0

Chromosomal Polymorphism in Cercopithecini: Cytogenomics Provides Evidence for Reticulate Evolution and Incomplete Reproductive Isolation DOI Creative Commons

Lauriane Cacheux,

Michèle Gerbault‐Seureau,

Peggy Motsch

и другие.

International Journal of Primatology, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0

Genomic basis of non-human-primate diversity and adaptation DOI
Christian Roos,

Lakshmi Seshadri,

Liye Zhang

и другие.

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0

Overcoming Challenges to Extracting and Sequencing Historical DNA to Support Primate Evolutionary Research and Conservation, with an Application to Galagos DOI
Anna Penna, Mary E. Blair,

Hsiao-Lei Lui

и другие.

International Journal of Primatology, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Язык: Английский

Процитировано

3

Breaking the rule: An exceptional Y chromosome introgression between deeply divergent primate species DOI Creative Commons
Axel Jensen,

Emma R. Horton,

Junior Amboko

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 10, 2024

Abstract Hybridization between distinct lineages is widespread in nature, with important implications for adaptation and speciation. If hybrids are fertile, alleles can introgress across species boundaries. Hybrid fitness often sex dependent, heterogametic showing lower than homogametic individuals, a phenomenon known as Haldane’s rule. Consequently, loci inherited strictly through the rarely introgress. We focus on Y-chromosomal history of guenons (tribe Cercopithecini), group African primates that hybridized extensively throughout their evolutionary history. Although our inferences suggest rule generally place, we uncover remarkable Y chromosome introgression event from Cercopithecus mitis into C. denti , which occurred ca. six million years after initial divergence. Only weak signal autosomal gene flow present, suggesting introgressing reached fixation very low frequency. use simulations to explore mechanisms at play, find selection needed achieve novel chromosome. identify number fixed protein differences introgressed ancestral Y, meiotic drive being an alternative mechanism adaptive introgression. Our results show ability produce viable fertile persisted guenons, providing exception

Язык: Английский

Процитировано

2

Improving baseline information on over-looked generalists: occurrence and mitochondrial DNA diversity of Campbell’s (Cercopithecus campbelli) and green monkeys (Chlorocebus sabaeus) in Guinea-Bissau, West Africa DOI Creative Commons
Ivo Colmonero-Costeira, Mariama Djaló, Nelson Luis Mello Fernandes

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Campbell’s (Cercopithecus campbelli) and green monkeys (Chlorocebus sabaeus) are sympatric medium-sized West African guenons (tribe Cercopithecini) that generally understudied in most of their distribution. Both species ecological generalists globally considered non-threatened, but populations decreasing locally. National conservation management lacks baseline information on local primate species. C. campbelli Chl. sabaeus the abundant primates out ten extant frequently hunted for meat consumption. Here, we aimed to update occurrence estimate country-wide mitochondrial (mtDNA) genetic diversity both From 2008 2022, conducted surveys four mainland protected areas islands Bijagós archipelago where known occur. We identified campbelli outside found relatively high mtDNA lower or no insular populations. Our results show significant signals geographically induced differentiation, particularly campbelli, which pattern population structure suggests female philopatry. In constrast, divergent Chl. haplotypes at close locations, suggesting dispersal. differentiated haplogroups with an estimated divergence time 1.53 1.16 Ma sabaeus, possibly linked Pleistocene climatic fluctuations. add further evidence Guinea-Bissau harbors country should be prioritized Africa.

Язык: Английский

Процитировано

1

Genealogical asymmetry under the IM model and a two-taxon test for gene flow DOI Creative Commons
Alexander Mackintosh, Derek Setter

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Abstract Methods for detecting gene flow between populations often rely on asymmetry in the average length of particular genealogical branches, with ABBA-BABA test being a well known example. Currently, asymmetry-based methods cannot be applied to pair and such analyses are instead performed using model-based methods. Here we investigate under two-population isolation-migration model. We focus genealogies where first coalescence event is lineages sampled from different populations, as external branches these have equal expected long there no post-divergence flow. show that unidirectional breaks this symmetry results recipient population having longer branches. derive expectations probability model propose simple statistic ( A m ) detect it genome sequence data. provides two-taxon only requires single unphased diploid each population, outgroup information. use analytic coalescent simulations explore how recombination, unequal effective sizes bidirectional influence find unambiguous evidence continent-island history. estimate data Heliconius butterflies Odocoileus deer, generating consistent previous analyses. Our work highlights signal overlooked date method complements existing approaches investigating demographic history recently diverged populations.

Язык: Английский

Процитировано

0

Phylogenomics of a genus of "Great Speciators" reveals rampant incomplete lineage sorting, gene flow, and mitochondrial capture in island systems DOI Creative Commons
Jenna M. McCullough, Chad M. Eliason, Shannon J. Hackett

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

The flora and fauna of island systems, especially those in the Indo-Pacific, are renowned for their high diversification rates outsized contribution to development evolutionary theories. total diversity geographic radiations many Indo-Pacific is often incompletely sampled phylogenetic studies due difficulty obtaining single endemic forms across Pacific relatively poor performance degraded DNA when using museum specimens inference relationships. New methods production analysis genome-wide datasets sourced from facilitating insights into complex histories these influential faunas. Here, we leverage whole genome resequencing (20X average coverage) extensive sampling all taxonomic within Todiramphus kingfishers, a rapid radiation largely "Great Speciators." We find that do not outright resolve relationships this clade: four types molecular markers (UCEs, BUSCOs, SNPs, mtDNA) tree building did well-supported concordant species-level topology. then uncover evidence widespread incomplete lineage sorting both ancient contemporary gene flow demonstrate how factors contribute conflicting histories. Our complete allowed us further identify novel case mitochondrial capture between two allopatric species, suggesting potential historical (but since lost) hybrid zone as islands were successively colonized. Taken together, results highlight increased genomic taxon can reveal patterns radiations.

Язык: Английский

Процитировано

0

Y chromosome introgression between deeply divergent primate species DOI Creative Commons
Axel Jensen,

Emma R. Horton,

Junior Amboko

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

0

Evolution of CEACAM pathogen decoy receptors in primates DOI Creative Commons
Wolfgang Zimmermann, Robert Kammerer

European Journal of Clinical Investigation, Год журнала: 2024, Номер 54(S2)

Опубликована: Дек. 1, 2024

Abstract Background CEACAM1 in leukocytes controls cell activation during inflammation. This and its expression epithelial cells led to frequent independent appropriation of as receptor by pathogens humans other species gain host access downregulate immune response. As a countermeasure, decoy receptors with CEACAM1‐like pathogen‐binding domains evolved. The granulocyte‐specific human CEACAM3 endocytic diverts CEACAM1‐binding neutrophils for internalization destruction. role the glycosylphosphatidylinositol‐anchored CEACAM5 CEACAM6 which can also bind CEACAM1‐targeting is less clear. Methods We analyzed selection CEACAMs avoid pathogen binding maintain similarity between 148 primate species. Results Notably, functional genes were not found gibbons New World monkeys. Interestingly, these primates exhibits similar high ratios rates nonsynonymous synonymous substitution (dN/dS) their N domain exons . High dN/dS are indicative diversification typically seen receptors. Human expressed on granulocytes cells. Therefore, could substitute missing CEACAM3. In nearly all investigated groups epithelially exhibit diversification. African populations, five high‐frequency polymorphisms observed region (I80V, V83A, I100T, I112V, I113T) 3‐4 combined same individual. These correspond sequences. Conclusion under most species, indicating function

Язык: Английский

Процитировано

0