bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2021,
Номер
unknown
Опубликована: Сен. 10, 2021
Abstract
PomBase
(
www.pombase.org
),
the
model
organism
database
(MOD)
for
fission
yeast
Schizosaccharomyces
pombe
,
supports
research
within
and
beyond
S.
community
by
integrating
presenting
genetic,
molecular,
cell
biological
knowledge
into
intuitive
displays
comprehensive
data
collections.
With
new
content,
novel
query
capabilities,
biologist-friendly
summaries
visualisation,
also
drives
innovation
in
MOD
community.
Cell,
Год журнала:
2023,
Номер
186(11), С. 2438 - 2455.e22
Опубликована: Май 1, 2023
The
generation
of
distinct
messenger
RNA
isoforms
through
alternative
processing
modulates
the
expression
and
function
genes,
often
in
a
cell-type-specific
manner.
Here,
we
assess
regulatory
relationships
between
transcription
initiation,
splicing,
3′
end
site
selection.
Applying
long-read
sequencing
to
accurately
represent
even
longest
transcripts
from
end,
quantify
mRNA
Drosophila
tissues,
including
transcriptionally
complex
nervous
system.
We
find
that
heads,
as
well
human
cerebral
organoids,
choice
is
globally
influenced
by
initiation
(TSS).
"Dominant
promoters,"
characterized
specific
epigenetic
signatures
p300/CBP
binding,
impose
transcriptional
constraint
define
splice
polyadenylation
variants.
In
vivo
deletion
or
overexpression
dominant
promoters
loss
disrupted
landscape.
Our
study
demonstrates
crucial
impact
TSS
on
regulation
transcript
diversity
tissue
identity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2021,
Номер
unknown
Опубликована: Сен. 10, 2021
Abstract
PomBase
(
www.pombase.org
),
the
model
organism
database
(MOD)
for
fission
yeast
Schizosaccharomyces
pombe
,
supports
research
within
and
beyond
S.
community
by
integrating
presenting
genetic,
molecular,
cell
biological
knowledge
into
intuitive
displays
comprehensive
data
collections.
With
new
content,
novel
query
capabilities,
biologist-friendly
summaries
visualisation,
also
drives
innovation
in
MOD
community.
