Advancements and Challenges of R-loops in Cancers: Biological Insights and Future Directions
Cancer Letters,
Год журнала:
2024,
Номер
610, С. 217359 - 217359
Опубликована: Ноя. 27, 2024
Язык: Английский
Biomolecular Condensates in Telomere Maintenance of ALT Cancer Cells
Journal of Molecular Biology,
Год журнала:
2025,
Номер
unknown, С. 168951 - 168951
Опубликована: Янв. 1, 2025
Alternative
Lengthening
of
Telomeres
(ALT)
pathway
is
a
telomerase-independent
mechanism
that
utilizes
homology-directed
repair
(HDR)
to
sustain
telomere
length
in
specific
cancers.
Biomolecular
condensates,
such
as
ALT-associated
promyelocytic
leukemia
nuclear
bodies
(APBs),
have
emerged
critical
players
the
ALT
pathway,
supporting
maintenance
ALT-positive
cells.
These
condensates
bring
together
DNA
proteins,
telomeric
repeats,
and
other
regulatory
elements.
By
regulating
replication
stress
promoting
synthesis,
create
an
environment
conducive
HDR-based
extension.
This
review
explores
recent
advancements
ALT,
focusing
on
understanding
role
biomolecular
how
they
impact
dynamics
stability.
Язык: Английский
RPS 2.0: an updated database of RNAs involved in liquid–liquid phase separation
Nucleic Acids Research,
Год журнала:
2024,
Номер
53(D1), С. D299 - D309
Опубликована: Окт. 26, 2024
Liquid-liquid
phase
separation
(LLPS)
is
a
crucial
process
for
the
formation
of
biomolecular
condensates
such
as
coacervate
droplets,
P-bodies
and
stress
granules,
which
play
critical
roles
in
many
physiological
pathological
processes.
Increasing
studies
have
shown
that
not
only
proteins
but
also
RNAs
role
LLPS.
To
host
LLPS-associated
RNAs,
we
previously
developed
database
named
'RPS'
2021.
In
this
study,
present
an
updated
version
RPS
2.0
(https://rps.renlab.cn/)
to
incorporate
newly
generated
data
new
driven
by
post-transcriptional
regulatory
mechanisms.
Currently,
hosts
171
301
entries
24
different
with
four
evidence
types,
including
'Reviewed',
'High-throughput
(LLPS
enrichment)',
perturbation)'
'Predicted',
five
event
'Expression',
'APA',
'AS',
'A-to-I'
'Modification'.
Additionally,
extensive
annotations
are
provided
2.0,
RNA
sequence
structure
features,
RNA-protein/RNA-RNA
interactions,
modifications,
well
diseases
related
annotations.
We
expect
will
further
promote
research
deepen
our
understanding
biological
functions
mechanisms
Язык: Английский
Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity
BioEssays,
Год журнала:
2024,
Номер
46(8)
Опубликована: Июнь 24, 2024
In
billion
years
of
evolution,
eukaryotes
preserved
the
chromosome
ends
with
arrays
guanine
repeats
surrounded
by
thymines
and
adenines,
which
can
form
stacks
four-stranded
planar
structure
known
as
G-quadruplex
(G4).
The
rationale
behind
evolutionary
conservation
G4
at
telomere
remained
elusive.
Our
recent
study
has
shed
light
on
this
matter
revealing
that
undergoes
oscillation
between
least
two
distinct
folded
conformations.
Additionally,
tumor
suppressor
BRCA2
exhibits
a
unique
mode
interaction
G4.
To
elaborate,
directly
interacts
G-triplex
(G3)-derived
intermediates
during
interconversion
different
states.
doing
so,
remodels
G4,
facilitating
restart
stalled
replication
forks.
review,
we
succinctly
summarize
findings
regarding
dynamicity
telomeric
emphasize
its
importance
in
maintaining
homeostasis,
physiological
consequences
losing
telomere.
Язык: Английский