The 2025 Nucleic Acids Research database issue and the online molecular biology database collection
Nucleic Acids Research,
Год журнала:
2024,
Номер
53(D1), С. D1 - D9
Опубликована: Дек. 10, 2024
The
2025
Nucleic
Acids
Research
database
issue
contains
185
papers
spanning
biology
and
related
areas.
Seventy
three
new
databases
are
covered,
while
resources
previously
described
in
the
account
for
101
update
articles.
Databases
most
recently
published
elsewhere
a
further
11
papers.
acid
include
EXPRESSO
multi-omics
of
3D
genome
structure
(this
issue's
chosen
Breakthrough
Resource
Article)
NAIRDB
Fourier
transform
infrared
data.
New
protein
predictions
human
isoforms
at
ASpdb
viral
proteins
BFVD.
UniProt,
Pfam
InterPro
have
all
provided
updates:
metabolism
signalling
covered
by
descriptions
STRING,
KEGG
CAZy,
updated
microbe-oriented
Enterobase,
VFDB
PHI-base.
Biomedical
research
is
supported,
among
others,
ClinVar,
PubChem
DrugMAP.
Genomics-related
Ensembl,
UCSC
Genome
Browser
dbSNP.
plant
cover
Solanaceae
(SolR)
Asteraceae
(AMIR)
families
an
from
NCBI
Taxonomy
also
features.
Database
Issue
freely
available
on
website
(https://academic.oup.com/nar).
At
NAR
online
Molecular
Biology
Collection
(http://www.oxfordjournals.org/nar/database/c/),
932
entries
been
reviewed
last
year,
74
added
226
discontinued
URLs
eliminated
bringing
current
total
to
2236
databases.
Язык: Английский
The detection, function, and therapeutic potential of RNA 2'-O-methylation
The Innovation Life,
Год журнала:
2024,
Номер
3(1), С. 100112 - 100112
Опубликована: Дек. 25, 2024
<p>RNA
modifications
play
crucial
roles
in
shaping
RNA
structure,
function,
and
metabolism.
Their
dysregulation
has
been
associated
with
many
diseases,
including
cancer,
developmental
disorders,
cardiovascular
as
well
neurological
immune-related
conditions.
A
particular
type
of
modification,
2'-O-methylation
(Nm)
stands
out
due
to
its
widespread
occurrence
on
all
four
types
nucleotides
(A,
U,
G,
C)
most
categories,
e.g.,
mRNA,
rRNA,
tRNA,
miRNA,
snRNA,
snoRNA,
viral
RNA.
Nm
is
the
addition
a
methyl
group
2'
hydroxyl
ribose
moiety
nucleoside.
Given
great
biological
significance
reported
association
we
first
reviewed
occurrences
functional
implications
various
species.
We
then
summarized
detection
methods,
ranging
from
biochemical
techniques
70’s
80’s
recent
methods
based
Illumina
sequencing,
artificial
intelligence
(AI)
models
for
computational
prediction,
latest
nanopore
sequencing
currently
under
active
development.
Moreover,
discussed
applications
realm
medicine,
highlighting
therapeutic
potential.
At
last,
present
perspectives
potential
research
directions,
aiming
offer
insights
future
investigations
modification.</p>
Язык: Английский