Unlocking the Potential of Two-Point Cells for Energy-Efficient and Resilient Training of Deep Nets

IEEE Transactions on Emerging Topics in Computational Intelligence, Год журнала: 2023, Номер 7(3), С. 818 - 828

Опубликована: Март 1, 2023

Context-sensitive two-point layer 5 pyramidal cells (L5PCs) were discovered as long ago 1999.However, the potential of this discovery to provide useful neural computation has yet be demonstrated.Here we show for first time how a transformative L5PCs-driven deep network (DNN), termed multisensory cooperative computing (MCC) architecture, can effectively process large amounts heterogeneous realworld audio-visual (AV) data, using far less energy compared best available 'point' neuron-driven DNNs.A novel highlydistributed parallel implementation on Xilinx UltraScale+ MPSoC device estimates savings up 245759 × 50000 µJ (i.e., 62% than baseline model in semi-supervised learning setup) where single synapse consumes 8e -5 µJ.In supervised setup, energy-saving potentially reach 1250x (per feedforward transmission) model.The significantly reduced activity MCC leads inherently fast and resilience against sudden damage.This remarkable performance pilot experiments demonstrates embodied neuromorphic intelligence our proposed L5PC that receives input from diverse neighbouring neurons context amplify transmission most salient relevant information onward transmission, overwhelmingly multimodal utilised at early stages on-chip training.Our approach opens new cross-disciplinary avenues future DNN training implementations posits radical shift current paradigms.

Язык: Английский

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Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells

PLoS Computational Biology, Год журнала: 2022, Номер 18(9), С. e1010506 - e1010506

Опубликована: Сен. 13, 2022

Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, a.k.a. I h channels. channels targeted multiple neuromodulatory pathways, and thus one the key ion-channel populations regulating cell activity. Previous observations theories attribute opposing effects on neuronal excitability due to their mildly hyperpolarized reversal potential. These difficult measure experimentally fine spatiotemporal landscape activity in dendrites, but computational models provide an efficient tool for studying this question a reduced generalizable setting. In work, we build upon existing biophysically detailed thick-tufted layer V model over- under-expression as well neuromodulation. We show that facilitate action potentials response proximal dendritic stimulus while they hinder distal at apical dendrite. also inhibitory is interactions between hot zone low voltage-activated Ca 2+ Our simulations suggest combination -enhancing neuromodulation part dendrite -inhibiting modulation can increase more than either two alone. analyses uncover -channel single-cell level shed light how these neurons integrate information enable higher-order functions brain.

Язык: Английский

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Cellular mechanisms of cooperative context-sensitive predictive inference

Current Research in Neurobiology, Год журнала: 2024, Номер 6, С. 100129 - 100129

Опубликована: Янв. 1, 2024

We argue that prediction success maximization is a basic objective of cognition and cortex, it compatible with but distinct from error minimization, neither requires subtractive coding, there clear neurobiological evidence for the amplification predicted signals, we are unconvinced by proposed in support coding. outline recent discoveries showing pyramidal cells on which our cognitive capabilities depend usually transmit information about input to their basal dendrites amplify transmission when distal apical provides context agrees feedforward both depolarizing, i.e., excitatory rather than inhibitory. Though these intracellular require level technical expertise beyond current abilities most neuroscience labs, they not controversial acclaimed as groundbreaking. note this cellular cooperative context-sensitivity greatly enhances mammalian neocortex, much remains be discovered concerning its evolution, development, pathology.

Язык: Английский

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The neural hierarchy of consciousness: A theoretical model and review on neurophysiology and NCCs

Neuropsychologia, Год журнала: 2022, Номер 169, С. 108202 - 108202

Опубликована: Март 8, 2022

Язык: Английский

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Enigma of Pyramidal Neurons: Chirality-Centric View on Biological Evolution. Congruence to Molecular, Cellular, Physiological, Cognitive, and Psychological Functions

Symmetry, Год журнала: 2024, Номер 16(3), С. 355 - 355

Опубликована: Март 15, 2024

The mechanism of brain information processing unfolds within spatial and temporal domains inherently linked to the concept space–time symmetry. Biological evolution, beginning with prevalent molecular chirality, results in handedness human cognitive psychological functions (the phenomena known as biochirality). key element chain chirality transfer from downstream upstream processes is pyramidal neuron (PyrN) morphology–function paradigm (archetype). most apparent landmark PyrNs geometry cell soma. However, “why/how PyrN’s soma gains shape quasi-tetrahedral symmetry” has never been explicitly articulated. Resolving above inquiry only possible based on broad-view assumption that encoding 3D space requires specific neuronal detector corresponding network. Accordingly, our hypothesis states if primary function PyrNs, at organism level, sensory symmetry perception, then best evolutionary-selected support sensory-motor coupling. biological system’s non-equilibrium (NE) state fundamentally an asymmetric, non-racemic, steady constituents. chiral theory conceptually agrees living systems have evolved exchange energy environment. involved developing studied detail. crucial missing element—the reference fundamental link between navigation—is main obstacle resolving question demand: why did PyrNs’ gain symmetry?

Язык: Английский

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Cellular psychology: relating cognition to context-sensitive pyramidal cells

Trends in Cognitive Sciences, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study

PLoS Computational Biology, Год журнала: 2023, Номер 19(6), С. e1011003 - e1011003

Опубликована: Июнь 29, 2023

How perception of sensory stimuli emerges from brain activity is a fundamental question neuroscience. To date, two disparate lines research have examined this question. On one hand, human neuroimaging studies helped us understand the large-scale dynamics perception. other work in animal models (mice, typically) has led to insight into micro-scale neural circuits underlying However, translating such humans been challenging. Here, using biophysical modeling, we show that auditory awareness negativity (AAN), an evoked response associated with target sounds noise, can be accounted for by synaptic input supragranular layers cortex (AC) present when are heard but absent they missed. This additional likely arises cortico-cortical feedback and/or non-lemniscal thalamic projections and targets apical dendrites layer-5 (L5) pyramidal neurons. In turn, leads increased local field potential activity, spiking L5 neurons, AAN. The results consistent current cellular conscious processing help bridge gap between macro micro levels perception-related activity.

Язык: Английский

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Context‐Sensitive Conscious Interpretation and Layer‐5 Pyramidal Neurons in Multistable Perception

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

There appears to be a fundamental difference between the two ways of how an object becomes perceptually experienced. One occurs when preconscious object-specifying sensory data processing crosses certain threshold so that constituents depiction become consciously The other already experienced features interpreted as belonging visual category. Surprisingly, experimental facts about neural markers conscious access gathered far do not allow us distinguish mechanisms responsible for these varieties. A cortical multicompartment layer-5 pyramidal neuron-based generic model is presented in order conceptualize possible mechanistic solution explanatory cul-de-sac. To support argument, review pertinent research compiled associated with from studies where physically invariant perceptual stimuli have underwent alternative interpretation(s) by brain. Recent developments newly emerging field cellular psycho(physio)logy are introduced, offering hypothetical distinguishing subserving content experience and interpretation. single cell-based approach brain process correlates perception added value beyond traditional inter-areal connectivity-based theoretical stances.

Язык: Английский

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A burst-dependent thalamocortical substrate for perceptual awareness

PLoS Computational Biology, Год журнала: 2025, Номер 21(4), С. e1012951 - e1012951

Опубликована: Апрель 7, 2025

Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model tactile threshold detection, we constructed biophysical that incorporated essential features thalamocortical anatomy and physiology. Our reproduced, mechanistically explains, the key vivo neural behavioural signatures model, as well response to set causal perturbations. We generalised same (with identical parameters) more complex task – visual rivalry found thalamic-mediated mechanism determined dominance. This led generation novel, directly testable, electrophysiological predictions. Analyses based on dynamical systems theory show simulations both detection arises from emergent systems-level dynamics loops.

Язык: Английский

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The Cooperative Neuron

Oxford University Press eBooks, Год журнала: 2023, Номер unknown

Опубликована: Апрель 20, 2023

Abstract The Cooperative Neuron roots our understanding of mental life, as consciously experienced and studied by psychologists, in recent discoveries cellular neurophysiology, which show that many neurons the mammalian neocortex have capabilities transcend those assumed twentieth-century psychology systems neuroscience. These receive information from other parts brain amplify their transmission when appropriate context. Amplification is defined quantified using advances theory contributions different inputs to can be distinguished. This context-sensitive cooperative style Big Data processing produces widespread coherence operations are localized within each a multitude local neuronal processors. book shows how this provides foundations for contextual disambiguation perception, selective attention, working memory imagery, emotional prioritization, cognitive control, learning, has profound implications neurobiology, psychology, neurology, psychiatry, philosophy. written wide audience, it explains neuroscience neuroscientists, both fields philosophers, students behavioural sciences, all intrigued enduring mystery brains minds. Finally, identifies issues inviting exploration.

Язык: Английский

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