Causal Effect of Fatty Fish Consumption on Influenza: Evidence From Two-Sample Mendelian Randomization DOI Creative Commons

X J Huang,

Z. P. Xie, Jie Li

и другие.

Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 1123 - 1133

Опубликована: Фев. 1, 2025

Influenza continues to pose a significant public health threat, with substantial morbidity and mortality worldwide. While vaccines antiviral treatments exist, the role of dietary factors, particularly fatty fish consumption, in modulating influenza susceptibility remains underexplored. Fatty fish, rich omega-3 polyunsaturated acids (PUFAs), is believed influence immune responses, but its specific impact on risk not fully understood. This study aims investigate causal relationship between consumption using two-sample Mendelian randomization (MR) approach. Genetic instruments for were derived from publicly available genome-wide association studies (GWAS). Summary-level data sourced largest GWAS available. A MR analysis was conducted inverse-variance weighted (IVW) MR-Egger methods assess effect risk. The revealed potential protective higher susceptibility. Genetically predicted intake associated reduced influenza, suggesting that PUFAs may help lower virus. Sensitivity analyses confirmed absence horizontal pleiotropy, supporting robustness results. provides evidence increased decreased influenza. These findings have implications recommendations strategies aimed at reducing burden. However, this has some limitations, such as gene-environment interactions predominantly European-based population, which limit generalizability. Future research should aim replicate these diverse populations further explore biological mechanisms linking

Язык: Английский

Causal Effect of Fatty Fish Consumption on Influenza: Evidence From Two-Sample Mendelian Randomization DOI Creative Commons

X J Huang,

Z. P. Xie, Jie Li

и другие.

Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 1123 - 1133

Опубликована: Фев. 1, 2025

Influenza continues to pose a significant public health threat, with substantial morbidity and mortality worldwide. While vaccines antiviral treatments exist, the role of dietary factors, particularly fatty fish consumption, in modulating influenza susceptibility remains underexplored. Fatty fish, rich omega-3 polyunsaturated acids (PUFAs), is believed influence immune responses, but its specific impact on risk not fully understood. This study aims investigate causal relationship between consumption using two-sample Mendelian randomization (MR) approach. Genetic instruments for were derived from publicly available genome-wide association studies (GWAS). Summary-level data sourced largest GWAS available. A MR analysis was conducted inverse-variance weighted (IVW) MR-Egger methods assess effect risk. The revealed potential protective higher susceptibility. Genetically predicted intake associated reduced influenza, suggesting that PUFAs may help lower virus. Sensitivity analyses confirmed absence horizontal pleiotropy, supporting robustness results. provides evidence increased decreased influenza. These findings have implications recommendations strategies aimed at reducing burden. However, this has some limitations, such as gene-environment interactions predominantly European-based population, which limit generalizability. Future research should aim replicate these diverse populations further explore biological mechanisms linking

Язык: Английский

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