International Journal of Research in Medical Sciences,
Год журнала:
2024,
Номер
12(6), С. 2038 - 2043
Опубликована: Май 31, 2024
Background:
Hortaea
werneckii,
a
melanized
yeast-like
fungus
is
the
cause
of
Tinea
nigra,
superficial
dermatomycosis.
The
lesions
are
differential
diagnosis
melanocytic
lesions.
nigra
mainly
affects
people
in
temperate
or
subtropical
climates
with
well-demarcated,
expanding,
hyperchromic
plaques
on
palms
soles.
Methods:
Skin
scrapings
from
various
suspected
fungal
aetiology
were
received
after
clinical
assessment
and
subjected
to
laboratory
procedures,
including
direct
KOH
(10%)
analysis,
culture
Sabouraud
dextrose
agar
(SDA),
incubation
at
25°C
37°C
for
28
days
which
was
further
confirmed
by
lactophenol
cotton
blue
preparation
slide
culture.
Results:
Out
295
samples
examined,
total
number
15
positive
werneckii
time
period
1st
January
2023
31st
December
2023.
7
patients
had
both
palmar
as
well
plantar
region
(46.66%),
3
each
(20%),
1
(6.66%)
scalp
face
scalp.
skin
taken
examined
10%
wet
mount
showed
positivity
11
(73.33%)
samples.
primary
isolation
done
SDA.
Conclusions:
most
common
nigra.
Pigmented
patches
may
be
confused
other
inflammatory
neoplastic
aetiology.
For
sufficient
Generally,
resolve
within
2
weeks
adequate
treatment.
To
conclude,
high
suspicion
should
maintained
timely
diagnose
disease,
avoid
unnecessary
invasive
investigation
early
administration
The Lancet Microbe,
Год журнала:
2024,
Номер
5(7), С. 717 - 724
Опубликована: Апрель 9, 2024
In
October,
2022,
WHO
published
the
first
fungal
priority
pathogen
list,
which
categorised
19
entities
into
three
groups
(critical,
high,
and
medium),
for
prioritisation
of
research
efforts.
The
final
ranking
was
determined
via
multiple
criteria
decision
analysis,
considering
both
development
needs
perceived
public
health
importance.
this
Personal
View,
we
discuss
positioning
pathogens,
namely,
Mucorales,
Candida
spp,
Histoplasma
Coccidioides
Paracoccidioides
Fusarium
eumycetoma
causative
agents,
Talaromyces
marneffei,
Pneumocystis
jirovecii,
while
expressing
concerns
about
potential
disparities
between
list
actual
disease
burden
associated
with
these
pathogens.
Finally,
propose
a
revised
that
also
considers
regional
in
diseases.
Pathogens,
Год журнала:
2023,
Номер
12(2), С. 293 - 293
Опубликована: Фев. 10, 2023
Fungal
infections
are
a
serious
global
concern
because
of
their
ability
to
spread
and
colonize
host
tissues
in
immunocompromised
individuals.
Such
have
been
frequently
reported
worldwide
currently
gaining
clinical
research
relevance
owing
resistant
character,
representing
bottleneck
treating
affected
people.
Resistant
fungi
an
emergent
public
health
threat.
The
upsurge
such
pathogens
has
led
new
toward
unraveling
the
destructive
potential
evoked
by
these
species.
Some
fungi—grouped
into
Candida,
Aspergillus,
Cryptococcus—are
causative
agents
severe
systemic
infections.
They
associated
with
high
mortality
rates
recently
described
as
sources
coinfection
COVID-hospitalized
patients.
Despite
efforts
elucidate
challenges
colonization,
dissemination,
infection
severity,
immunopathogenesis
fungal
diseases
remains
pivotal
characteristic
burden
elimination.
struggle
between
immune
system
physiological
strategies
maintain
cellular
viability
is
complex.
In
this
brief
review,
we
highlight
drug
resistance
phenotypes
significance,
taking
consideration
physiopathology
how
scientific
community
could
orchestrate
avoid
dissemination
deaths.
ABSTRACT
Background
Post‐tuberculosis
lung
disease
(PTLD)
is
a
precursor
to
Aspergillus
‐related
diseases.
While
Chronic
Pulmonary
Aspergillosis
(CPA)
has
been
extensively
studied
in
the
background
of
tuberculosis,
Allergic
Bronchopulmonary
(ABPA)
reported
sporadically
with
limited
information
on
its
prevalence,
clinical‐radiological
features,
and
treatment
outcomes.
Objective
This
study,
conducted
high
TB
burden
setting,
aimed
address
this
knowledge
gap
by
systematically
evaluating
ABPA
PTLD
patients.
Methods
retrospective
cohort
study
screened
patients
presenting
respiratory
or
constitutional
symptoms
persisting
for
more
than
3
months.
The
objective
was
report
clinical‐radiological‐laboratory
data,
outcomes
ABPA‐PTLD
compared
CPA
(CPA‐PTLD)
(PTLD
only).
Results
Out
total
1012
patients,
seen
2.27%,
20.75%
sensitization
0.7%.
primarily
presented
breathlessness
(91.3%)
cough
(82.6%)
while
haemoptysis
(43.5%),
weight
loss
(13%),
anorexia
(21.7%)
were
also
observed,
albeit
less
commonly
CPA‐PTLD.
Bronchiectasis
(100%)
nodules
(87%)
frequent
whereas
consolidation
(21.7%),
cavities
(30.4%),
pleural
thickening
(8.7%),
‘fungal
ball’
(9.1%)
seen,
although
Most
received
azoles
(78%)
as
first‐line
therapy,
symptomatic
improvement
(partial/complete)
observed
~78%.
Conclusion
may
occur
specific
clinical
(e.g.,
haemoptysis)
radiological
cavity
fungal
ball)
features
uncommon
other
types
ABPA,
but
resembling
conditions.
Future
studies
should
focus
identifying
differences
natural
course
appropriate
paradigms
occurring
asthma
cystic
fibrosis
Allergology International,
Год журнала:
2023,
Номер
72(4), С. 493 - 506
Опубликована: Авг. 4, 2023
Poorly
controlled
asthma
is
especially
common
in
low
resource
countries.
Aside
from
lack
of
access
to,
or
poor
technique
with,
inhaled
beta-2
agonists
and
corticosteroids,
the
most
problematic
forms
are
frequently
associated
with
both
fungal
allergy
exposure,
adults
leading
to
more
exacerbations
worse
asthma.
The
umbrella
term
'fungal
asthma'
describes
many
disorders
linked
exposure
and/or
fungi.
One
endotype,
ABPA,
usually
marked
by
a
very
high
IgE
its
differential
diagnosis
reviewed.
Both
ABPA
bronchitis
bronchiectasis
thick
excess
airway
mucus
production.
Dermatophyte
skin
infection
can
worsen
eradication
improves
Exposure
fungi
workplace,
home
schools,
often
damp
water-damaged
buildings
worsens
asthma,
remediation
symptom
control
reduces
exacerbations.
Antifungal
therapy
beneficial
for
as
demonstrated
nine
13
randomised
studies,
reducing
symptoms,
corticosteroid
need
while
improving
lung
function.
Other
useful
therapies
include
azithromycin
some
biologics
approved
treatment
severe
If
all
individuals
poorly
could
be
'relieved'
their
through
antifungal
without
systemic
health
benefits
would
enormous
relatively
inexpensive,
long
over
20
million
children.
carries
toxicity,
drug
interactions
triazole
resistance
risks,
data
incomplete.
Here
we
summarise
what
known
remains
uncertain
about
this
complex
topic.
JMIR Research Protocols,
Год журнала:
2024,
Номер
13, С. e54672 - e54672
Опубликована: Фев. 16, 2024
Background
Fungal
infections
are
now
a
great
public
health
threat,
especially
in
those
with
underlying
risk
factors
such
as
neutropenia,
diabetes,
high-dose
steroid
treatment,
cancer
chemotherapy,
prolonged
intensive
care
unit
stay,
and
so
on,
which
can
lead
to
mycoses
higher
mortality
rates.
The
rates
of
these
have
been
steadily
increasing
over
the
past
2
decades
due
population
patients
who
immunocompromised.
However,
data
regarding
exact
burden
infection
still
not
available
from
India.
Therefore,
this
registry
was
initiated
collate
systematic
on
invasive
fungal
(IFIs)
across
country.
Objective
primary
aim
study
is
create
multicenter
digital
clinical
monitor
trends
IFIs
emerging
diseases,
well
early
signals
any
potential
outbreak
region.
will
also
capture
information
antifungal
resistance
patterns
contribution
overall
morbidity
inpatient
various
conditions.
Methods
This
multicenter,
prospective,
noninterventional
observational
be
conducted
by
Indian
Council
Medical
Research
through
web-based
collection
method
8
Advanced
Mycology
Diagnostic
Centers
Data
age,
gender,
signs
symptoms,
date
admission,
discharge
or
death,
diagnostic
tests
performed,
identified
pathogen
details,
susceptibility
testing,
outcome,
obtained
hospital
records.
Descriptive
multivariate
statistical
methods
applied
investigate
manifestations,
variables,
treatment
outcomes.
Results
These
expected
find
hidden
cases
setting.
facilitate
enhancement
precision
diagnosis
prompt
modalities
response
drug
sensitivity
tests.
improve
our
understanding
IFIs,
support
evidence-based
decision-making
ability,
encourage
policies
actions.
Conclusions
diseases
neglected
problem.
Fewer
facilities,
scanty
published
data,
increased
vulnerable
patient
groups
make
situation
worse.
first
generated
increase
related
diagnosis,
prevention
India
addressing
pertinent
gaps
mycology.
initiative
ensure
visible
impact
International
Registered
Report
Identifier
(IRRID)
DERR1-10.2196/54672