Incidence of Hortaea werneckii in a tertiary care centre in Maharashtra DOI Open Access

Sakshi Mehta,

Jayshree Bhakre,

Sharvani Kante

и другие.

International Journal of Research in Medical Sciences, Год журнала: 2024, Номер 12(6), С. 2038 - 2043

Опубликована: Май 31, 2024

Background: Hortaea werneckii, a melanized yeast-like fungus is the cause of Tinea nigra, superficial dermatomycosis. The lesions are differential diagnosis melanocytic lesions. nigra mainly affects people in temperate or subtropical climates with well-demarcated, expanding, hyperchromic plaques on palms soles. Methods: Skin scrapings from various suspected fungal aetiology were received after clinical assessment and subjected to laboratory procedures, including direct KOH (10%) analysis, culture Sabouraud dextrose agar (SDA), incubation at 25°C 37°C for 28 days which was further confirmed by lactophenol cotton blue preparation slide culture. Results: Out 295 samples examined, total number 15 positive werneckii time period 1st January 2023 31st December 2023. 7 patients had both palmar as well plantar region (46.66%), 3 each (20%), 1 (6.66%) scalp face scalp. skin taken examined 10% wet mount showed positivity 11 (73.33%) samples. primary isolation done SDA. Conclusions: most common nigra. Pigmented patches may be confused other inflammatory neoplastic aetiology. For sufficient Generally, resolve within 2 weeks adequate treatment. To conclude, high suspicion should maintained timely diagnose disease, avoid unnecessary invasive investigation early administration

Язык: Английский

The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation DOI Creative Commons
Giacomo Casalini, Andrea Giacomelli, Spinello Antinori

и другие.

The Lancet Microbe, Год журнала: 2024, Номер 5(7), С. 717 - 724

Опубликована: Апрель 9, 2024

In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 entities into three groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both development needs perceived public health importance. this Personal View, we discuss positioning pathogens, namely, Mucorales, Candida spp, Histoplasma Coccidioides Paracoccidioides Fusarium eumycetoma causative agents, Talaromyces marneffei, Pneumocystis jirovecii, while expressing concerns about potential disparities between list actual disease burden associated with these pathogens. Finally, propose a revised that also considers regional in diseases.

Язык: Английский

Процитировано

43

Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM DOI Creative Commons
Oliver A. Cornely, Rosanne Sprute, Matteo Bassetti

и другие.

The Lancet Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

19

Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections DOI Creative Commons
Leonardo Martins‐Santana, Caroline Patini Rezende, Antônio Rossi

и другие.

Pathogens, Год журнала: 2023, Номер 12(2), С. 293 - 293

Опубликована: Фев. 10, 2023

Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such have been frequently reported worldwide currently gaining clinical research relevance owing resistant character, representing bottleneck treating affected people. Resistant fungi an emergent public health threat. The upsurge such pathogens has led new toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, Cryptococcus—are causative agents severe systemic infections. They associated with high mortality rates recently described as sources coinfection COVID-hospitalized patients. Despite efforts elucidate challenges colonization, dissemination, infection severity, immunopathogenesis fungal diseases remains pivotal characteristic burden elimination. struggle between immune system physiological strategies maintain cellular viability is complex. In this brief review, we highlight drug resistance phenotypes significance, taking consideration physiopathology how scientific community could orchestrate avoid dissemination deaths.

Язык: Английский

Процитировано

26

Microbial lipopeptides: their pharmaceutical and biotechnological potential, applications, and way forward DOI

K. P. Sreelakshmi,

M. Madhuri,

R. Swetha

и другие.

World Journal of Microbiology and Biotechnology, Год журнала: 2024, Номер 40(4)

Опубликована: Март 15, 2024

Язык: Английский

Процитировано

8

Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis DOI Creative Commons

Anshuman Sengupta,

Animesh Ray, Ashish Datt Upadhyay

и другие.

The Lancet Infectious Diseases, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

7

Allergic Bronchopulmonary Aspergillosis in Patients With Prior Pulmonary Tuberculosis: A Study on the Burden, Clinic‐Radiological Features, Treatment Outcomes and Comparison With Chronic Pulmonary Aspergillosis and Post‐Tubercular Lung Disease Patients DOI
Anuj Ajayababu, Ved Prakash Meena, Prayas Sethi

и другие.

Mycoses, Год журнала: 2025, Номер 68(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Post‐tuberculosis lung disease (PTLD) is a precursor to Aspergillus ‐related diseases. While Chronic Pulmonary Aspergillosis (CPA) has been extensively studied in the background of tuberculosis, Allergic Bronchopulmonary (ABPA) reported sporadically with limited information on its prevalence, clinical‐radiological features, and treatment outcomes. Objective This study, conducted high TB burden setting, aimed address this knowledge gap by systematically evaluating ABPA PTLD patients. Methods retrospective cohort study screened patients presenting respiratory or constitutional symptoms persisting for more than 3 months. The objective was report clinical‐radiological‐laboratory data, outcomes ABPA‐PTLD compared CPA (CPA‐PTLD) (PTLD only). Results Out total 1012 patients, seen 2.27%, 20.75% sensitization 0.7%. primarily presented breathlessness (91.3%) cough (82.6%) while haemoptysis (43.5%), weight loss (13%), anorexia (21.7%) were also observed, albeit less commonly CPA‐PTLD. Bronchiectasis (100%) nodules (87%) frequent whereas consolidation (21.7%), cavities (30.4%), pleural thickening (8.7%), ‘fungal ball’ (9.1%) seen, although Most received azoles (78%) as first‐line therapy, symptomatic improvement (partial/complete) observed ~78%. Conclusion may occur specific clinical (e.g., haemoptysis) radiological cavity fungal ball) features uncommon other types ABPA, but resembling conditions. Future studies should focus identifying differences natural course appropriate paradigms occurring asthma cystic fibrosis

Язык: Английский

Процитировано

1

A Systematic Review of the Therapeutic Outcome of Mucormycosis DOI Creative Commons
Liyanage Shamithra Madhumali Sigera, David W. Denning

Open Forum Infectious Diseases, Год журнала: 2023, Номер 11(1)

Опубликована: Дек. 30, 2023

Mucormycosis is a potentially lethal mycosis. We reviewed peer-reviewed publications on mucormycosis to assess therapeutic outcomes.

Язык: Английский

Процитировано

17

Poorly controlled asthma – Easy wins and future prospects for addressing fungal allergy DOI Creative Commons
David W. Denning, Lorraine Tsitsi Pfavayi

Allergology International, Год журнала: 2023, Номер 72(4), С. 493 - 506

Опубликована: Авг. 4, 2023

Poorly controlled asthma is especially common in low resource countries. Aside from lack of access to, or poor technique with, inhaled beta-2 agonists and corticosteroids, the most problematic forms are frequently associated with both fungal allergy exposure, adults leading to more exacerbations worse asthma. The umbrella term 'fungal asthma' describes many disorders linked exposure and/or fungi. One endotype, ABPA, usually marked by a very high IgE its differential diagnosis reviewed. Both ABPA bronchitis bronchiectasis thick excess airway mucus production. Dermatophyte skin infection can worsen eradication improves Exposure fungi workplace, home schools, often damp water-damaged buildings worsens asthma, remediation symptom control reduces exacerbations. Antifungal therapy beneficial for as demonstrated nine 13 randomised studies, reducing symptoms, corticosteroid need while improving lung function. Other useful therapies include azithromycin some biologics approved treatment severe If all individuals poorly could be 'relieved' their through antifungal without systemic health benefits would enormous relatively inexpensive, long over 20 million children. carries toxicity, drug interactions triazole resistance risks, data incomplete. Here we summarise what known remains uncertain about this complex topic.

Язык: Английский

Процитировано

10

One Health Approach to Addressing Fungal Infection Disparities DOI
Mallika Sengupta,

Aditya Kundu,

Gayatree Nayak

и другие.

Current Fungal Infection Reports, Год журнала: 2024, Номер 18(1), С. 13 - 25

Опубликована: Янв. 16, 2024

Язык: Английский

Процитировано

4

Pan-Indian Clinical Registry of Invasive Fungal Infections Among Patients in the Intensive Care Unit: Protocol for a Multicentric Prospective Study DOI Creative Commons
Anup Kumar Ojha, Venencia Albert, Saurabh Sharma

и другие.

JMIR Research Protocols, Год журнала: 2024, Номер 13, С. e54672 - e54672

Опубликована: Фев. 16, 2024

Background Fungal infections are now a great public health threat, especially in those with underlying risk factors such as neutropenia, diabetes, high-dose steroid treatment, cancer chemotherapy, prolonged intensive care unit stay, and so on, which can lead to mycoses higher mortality rates. The rates of these have been steadily increasing over the past 2 decades due population patients who immunocompromised. However, data regarding exact burden infection still not available from India. Therefore, this registry was initiated collate systematic on invasive fungal (IFIs) across country. Objective primary aim study is create multicenter digital clinical monitor trends IFIs emerging diseases, well early signals any potential outbreak region. will also capture information antifungal resistance patterns contribution overall morbidity inpatient various conditions. Methods This multicenter, prospective, noninterventional observational be conducted by Indian Council Medical Research through web-based collection method 8 Advanced Mycology Diagnostic Centers Data age, gender, signs symptoms, date admission, discharge or death, diagnostic tests performed, identified pathogen details, susceptibility testing, outcome, obtained hospital records. Descriptive multivariate statistical methods applied investigate manifestations, variables, treatment outcomes. Results These expected find hidden cases setting. facilitate enhancement precision diagnosis prompt modalities response drug sensitivity tests. improve our understanding IFIs, support evidence-based decision-making ability, encourage policies actions. Conclusions diseases neglected problem. Fewer facilities, scanty published data, increased vulnerable patient groups make situation worse. first generated increase related diagnosis, prevention India addressing pertinent gaps mycology. initiative ensure visible impact International Registered Report Identifier (IRRID) DERR1-10.2196/54672

Язык: Английский

Процитировано

4