Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер unknown, С. 1 - 13
Опубликована: Ноя. 18, 2024
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Язык: Английский
Pathogens, Год журнала: 2025, Номер 14(3), С. 262 - 262
Опубликована: Март 7, 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, emerged in late 2019 and rapidly evolved into pandemic around the world. The disease (COVID-19) has dramatically changed epidemiology seasonality of other traditional viruses, e.g., influenza, syncytial virus, enterovirus, etc. These viruses have transmission mode clinical symptoms similar to SARS-CoV-2 but may differ outcomes management. Co-infection between one or more been reported literature shown mixed evidence outcomes. With evolving mild Omicron variants, it is believed that co-circulates with which turn affect course viral infections. In response these changes, multiplex molecular tests for are attracting attention field developed variety testing modalities. this review, we describe (i.e., Northern Hemisphere), epidemiology, significance their co-infection post-COVID era. Furthermore, review commonly used applications detection co-infections. Altogether, not only sheds light on infections co-infections era, also provides insights laboratory-based diagnoses using testing.
Язык: Английский
Процитировано
6
Mycopathologia, Год журнала: 2025, Номер 190(1)
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
International Journal of Infectious Diseases, Год журнала: 2023, Номер 131, С. 166 - 172
Опубликована: Апрель 11, 2023
The risk factors for late-onset Pneumocystis jirovecii pneumonia (PCP) after liver transplantation (LT) have not been well studied. We aimed to analyze the clinical features preceding PCP in LT recipients that would guide individualized prophylaxis.Among 742 patients who underwent and routine prophylaxis from January 2009 through December 2019 at Severance Hospital, 27 developed PCP. conducted a retrospective case-control study matching each patient with four controls analyzed PCP.After 6 months, post-transplant cases increased steadily an overall incidence of 6.36 per 1000 patient-year. PCP-related mortality was 37.0%. In multivariate analyses, age ≥65 years (odds ratio [OR], 13.305; 95% confidence interval [CI], 2.507-70.618; P = 0.002), cytomegalovirus infection (OR, 5.390; CI, 1.602-18.132; 0.006), steroid pulse therapy 6.564; 1.984-21.719; hepatocellular carcinoma recurrence 18.180; 3.420-96.636; 0.001), lymphocytopenia 3.758; 1.176-12.013; 0.026) were independently associated PCP.Late-onset remains lethal is LT, infection, therapy, recurrence, lymphocytopenia. Targeted considering these could improve prevention this potentially complication.
Язык: Английский
Процитировано
7
Journal of Fungi, Год журнала: 2023, Номер 9(8), С. 838 - 838
Опубликована: Авг. 11, 2023
Background: Very few cases of Pneumocystis jirovecii pneumonia (PJP) have been reported in COVID-19 so far, and mostly patients with concomitant HIV infection or solid-organ transplant recipients. Despite being associated lymphopenia the use steroids, there are no studies specifically aimed at investigating risk factors for PJP COVID-19. Methods: A retrospective case-control study was performed. We matched controls a 1:2 ratio, based on age ± 10 years, transplantation (SOT), hematological malignancies, setting development (ICU vs. non-ICU). direct immunofluorescence assay bronchoalveolar lavage fluid used to diagnose PJP. Results: enrolled 54 patients. Among 18 PJP, 16 were diagnosed as “proven”. Seven eighteen immunocompromised, while other had previous immunological impairment. Patients significantly lower median lymphocyte values (p = 0.033), longer duration 0.014), higher dose steroid received 0.026), CRP 0.005), SARS-CoV-2 vaccination rate than 0.029). Cumulative is independent factor (OR 1.004, 95%CI 1–1.008, p 0.042). Conclusions: develops regardless immunosuppressive conditions severity disease, it correlated corticosteroid received.
Язык: Английский
Процитировано
7
Revista Española de Quimioterapia, Год журнала: 2024, Номер 37(3), С. 221 - 251
Опубликована: Март 4, 2024
Pneumonia is a multifaceted illness with wide range of clinical manifestations, degree severity and multiple potential causing microorganisms. Despite the intensive research recent decades, community-acquired pneumonia remains third-highest cause mortality in developed countries first due to infections; hospital-acquired main death from nosocomial infection critically ill patients. Guidelines for management this disease are available world wide, but there questions which generate controversy, latest advances make it difficult stay them up date. A multidisciplinary approach can overcome these limitations also aid improve results. Spanish medical societies involved diagnosis treatment have made collaborative effort actualize integrate last expertise about infection. The aim paper reflect knowledge, communicated Fifth Day Spain. It reviews most important disorder, such as microbiological diagnosis, antibiotic sequential therapy, beta-lactam allergic patient, preventive measures, unusual or multi-resistant microorganisms adjuvant advanced therapies Intensive Care Unit.
Язык: Английский
Процитировано
1
Transplant Infectious Disease, Год журнала: 2024, Номер 26(3)
Опубликована: Апрель 11, 2024
In this case, a 64-year-old male with history of simultaneous orthotopic liver transplant and cadaveric renal presented five years prior persistent fevers two days after positive SARS-CoV-2 nasal PCR. A CT scan the chest on hospital day nine revealed innumerable 1-2 mm nodules in miliary pattern throughout lung. (1,3)-β-D-glucan 11 was 133 pg/mL. article, approach, diagnostic management strategies for patients diagnosis COVID-19 recipient are discussed.
Язык: Английский
Процитировано
1
Microorganisms, Год журнала: 2023, Номер 11(12), С. 2839 - 2839
Опубликована: Ноя. 22, 2023
Pneumocystis jirovecii pneumonia (PJP) is an invasive fungal infection (IFI) that occurs mainly in immunocompromised hosts. After observing a high prevalence of PJP as complication COVID-19 immunocompetent patients, we conducted study to evaluate the P. colonization with PCR on oral washing samples (OWS) among non-immunocompromised and non-critical patients admitted at our university hospital.All over 18 years age Infectious Diseases Unit for SARS-CoV-2 between July 2021 December 2022 were included. Patients undergoing mechanical ventilation or ECMO, those risk factors developing PJP, receiving prophylaxis excluded. Samples collected by gargling 10 mL 0.9% NaCl day 14 hospital stay discharge.Of 290 screened 59 (20%) met inclusion criteria enrolled. Only 1 (1.7%) tested positive detection PCR, same patient was only one develop follow-up period.Our results are line previous findings other studies confirmed very low OWS population. Despite limitations study, fact who cohort leads us reflect role this non-invasive sample predicting COVID-19.
Язык: Английский
Процитировано
3
Опубликована: Июнь 16, 2023
Background Very few cases of Pneumocystis jirovecii pneumonia (PCP) have been reported in COVID-19 so far, mostly patients with concomitant HIV infection or solid organ transplant recipients. Despite is associated lymphopenia and use steroids, there are no studies specifically aimed to investigate risk factors for PCP Methods retrospective case-control study a cohort confirmed COVID-19. Direct immunofluorescence assay on respiratory samples was used diagnose PCP. Results We enrolled 54 patients. Patients had significant lower median lymphocyte values (p=0.033), longer disease duration (p=0.014), higher cumulative dose steroid received (p=0.026), CRP (p=0.005) SARS-CoV-2 vaccination rate than controls (p=0.029). Cumulative (p=0.042) the highest value during stay (p=0.012) were identified as factor PCP, while one (p=0.029) two doses (p=0.049) protective although not independently associated. Conclusions develops regardless immunosuppressive conditions. However, significantly steroidal dose, high lack vaccination.
Язык: Английский
Процитировано
2
Опубликована: Авг. 31, 2023
BACKGROUND Pneumocystis jirovecii pneumonia (PJP) is an invasive fungal infection (IFI) that occurs mainly in immunocompromised hosts. As we observed a high prevalence of PCP as complication COVID-19 immunocompetent patients, conducted study to evaluate the P. colonization with PCR on oral washing samples (OWS) among non-immunocompromised and non-critical patients admitted for at our University Hospital. METHODS All over 18 years age Infectious Diseases Unit SARS-CoV-2 between July 2021 December 2022 were included. Patients undergoing mechanical ventilation or ECMO, those risk factors developing PCP, receiving prophylaxis excluded. Samples collected by gargling 10mL 0.9% NaCl day 14 hospital stay discharge. RESULTS Of 290 screened 59 (20%) met inclusion criteria enrolled. Only one (1.7%) resulted positive detection same patient was only develop follow up period. CONCLUSION Our results are line previous findings other studies confirmed very low OWS population. Despite limitation study, fact who tested cohort leads us reflect role this non-invasive sample predicting COVID-19.
Язык: Английский
Процитировано
2
Опубликована: Авг. 7, 2023
Background Very few cases of Pneumocystis jirovecii pneumonia (PCP) have been reported in COVID-19 so far, mostly patients with concomitant HIV infection or solid organ transplant recipients. Despite is associated lymphopenia and use steroids, there are no studies specifically aimed to investigate risk factors for PCP Methods retrospective case-control study a cohort confirmed COVID-19. Direct immunofluorescence assay on respiratory samples was used diagnose PCP. Results We enrolled 54 patients. Patients had significant lower median lymphocyte values (p=0.033), longer disease duration (p=0.014), higher cumulative dose steroid received (p=0.026), CRP (p=0.005) SARS-CoV-2 vaccination rate than controls (p=0.029). Cumulative (p=0.042) the highest value during stay (p=0.012) were identified as factor PCP, while one (p=0.029) two doses (p=0.049) protective although not independently associated. Conclusions develops regardless immunosuppressive conditions. However, significantly steroidal dose, high lack vaccination.
Язык: Английский
Процитировано
1