Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey DOI Creative Commons

Liya Pan,

Jin Li

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 28, 2025

Insulin resistance (IR) has been reported to be associated with aging; however, few studies have investigated the relationship between IR and biological age (BA). The Triglyceride–glucose (TyG) index is a recognized marker of IR. Currently, there insufficient evidence regarding TyG aging. This study aims provide deeper insights into connections We conducted cross-sectional using data from National Health Nutrition Examination Survey (NHANES), including 12,074 adults (aged 20 older) 2001–2010 2015–2018 cycles. Comprehensive BA were extracted for analysis. To explore BA, linear regressions employed, while logistic regression models used examine association accelerated Additionally, trend tests, subgroup analyses, smoothed fitted curves assess robustness findings. included participants mean 46.91 years (SD, 16.64); these, 50.25% female 49.75% male. Each 1-unit increase in was 1.64-year rise Klemera–Doubal method (KDM) 117% higher risk Similarly, each corresponded 0.40-year phenotypic age, resulting 15% analysis also revealed nonlinear positive relationships aging, particularly KDM (P non-linearity < 0.001) = 0.005), turning point at 8.66. Across all subgroups, consistently showed correlation even presence significant interactions. There Higher levels are linked increased greater

Язык: Английский

Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality DOI Creative Commons
Jiayu Qiu, Hui Fang, Dingwei Liu

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 10, 2025

The aim of this study was to explore the systemic inflammation response in relation mortality Helicobacter pylori (H. pylori) infection, and whether relationship mediated by accelerated biological aging. This cross-sectional encompassed U.S. participants from National Health Nutrition Examination Survey (NHANES) 1999–2000. Kaplan-Meier survival curve, Cox regression analysis, K-means clustering, mediation analysis restricted cubic spline (RCS) were used relationships between inflammatory markers, aging, H. infection all-cause mortality. A total 3509 enrolled form NHANES Compared with seronegative participants, seropositive had significantly higher (P < 0.001). Among these both phenotypic age acceleration (PhenoAgeAccel) positively associated increased levels significant indirect effect markers (neutrophil count index (SIRI)) on through PhenoageAccel found, proportions 50.0% 49.1%, respectively. elevation blood is an risk among population, aging might be one its mechanisms.

Язык: Английский

Процитировано

0
Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey DOI Creative Commons

Liya Pan,

Jin Li

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 28, 2025

Insulin resistance (IR) has been reported to be associated with aging; however, few studies have investigated the relationship between IR and biological age (BA). The Triglyceride–glucose (TyG) index is a recognized marker of IR. Currently, there insufficient evidence regarding TyG aging. This study aims provide deeper insights into connections We conducted cross-sectional using data from National Health Nutrition Examination Survey (NHANES), including 12,074 adults (aged 20 older) 2001–2010 2015–2018 cycles. Comprehensive BA were extracted for analysis. To explore BA, linear regressions employed, while logistic regression models used examine association accelerated Additionally, trend tests, subgroup analyses, smoothed fitted curves assess robustness findings. included participants mean 46.91 years (SD, 16.64); these, 50.25% female 49.75% male. Each 1-unit increase in was 1.64-year rise Klemera–Doubal method (KDM) 117% higher risk Similarly, each corresponded 0.40-year phenotypic age, resulting 15% analysis also revealed nonlinear positive relationships aging, particularly KDM (P non-linearity < 0.001) = 0.005), turning point at 8.66. Across all subgroups, consistently showed correlation even presence significant interactions. There Higher levels are linked increased greater

Язык: Английский

Процитировано

0