Biodegradable Polymeric Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Hemostasis
is
the
initial
step
in
wound
healing,
yet
significant
challenges,
such
as
massive
bleeding
and
infection,
often
arise.
In
this
study,
we
developed
amphiphilic
biodegradable
polyester-based
segmented
polyurethane
(SPU)
microspheres
modified
with
epigallocatechin
gallate
(EGCG)-Ag
nanoparticles
calcium-alginate
cross-linking
shell,
combining
blood
absorption
pro-coagulation
properties
of
Ca2+
negative
charge
EGCG
for
synergistic
hemostatic
effects
across
various
stages
coagulation
cascade.
The
vitro
clotting
time
SPU@EAg@CaAlg
microsphere
(328.7
s)
was
reduced
by
half
compared
to
SPU
(685.0
s).
exhibited
a
loss
three
rat
models.
Additionally,
EGCG-Ag
imparted
strong
antibacterial
anti-inflammatory
both
vivo.
vivo
infected
model
demonstrated
that
effectively
eliminated
bacteria
levels
pro-inflammatory
factors,
thereby
promoting
healing.
Thus,
present
promising
candidate
effective
applications.
Язык: Английский
Preparation of pH-enzyme dual-responsive gel microspheres and their treatment of ulcerative colitis
Ying-Jie Geng,
Y D Li,
Haolong Qi
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141567 - 141567
Опубликована: Фев. 27, 2025
Язык: Английский
W-GA Nanodots with Multienzyme Activities Alleviate the Inflammatory Microenvironment in the Treatment of Acute Wounds
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101662 - 101662
Опубликована: Март 1, 2025
Язык: Английский
Dual Biopolymer Layer Using Nanoparticles with Active Substance Enclosed in Microcapsules: Innovative Solution for Slow Release of Ginkgo biloba L. Extract for Potential Therapies
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3066 - 3066
Опубликована: Март 27, 2025
The
dynamic
development
of
various
branches
medicine
and
pharmacy,
along
with
the
emergence
new
preventive
alternative
therapies
for
diseases,
creates
opportunities
solutions
utilizing
carriers
active
substances.
Their
therapeutic
effect
may
occur
through
direct
contact
skin
lesions
or
indirectly,
where
medicinal
substances
penetrate
capillary
network
in
deeper
layers
reach
bloodstream.
aim
research
was
to
obtain
a
matrix
consisting
two
renewable-source
polymers
(chitosan
ethylcellulose)
core
material
derived
from
Ginkgo
biloba
green
leaf
extract
(GBE).
obtained
ethylcellulose
microcapsules
encapsulated
chitosan
nanoparticles
{Et[Ch(GB)NP]}
were
characterized
respect
size,
shape,
surface
morphology
(SEM
microscopy),
substance
release
kinetics
(UV-VIS
mathematical
models).
analyzed
using
UV-VIS
spectroscopy
models.
released
components
assessed
microbiologically
activity
against
six
bacterial
strains
fungal
strains,
as
well
chromatographically
HPLC-ESI-QTOF-MS/MS
fingerprinting.
dual
polymer
layer
exhibited
slow
material,
which
demonstrated
microbiological
activity.
strongest
antimicrobial
effects
observed
Klebsiella
pneumoniae
Salmonella
enteritidis,
minimum
inhibitory
concentration
(MIC)
410
µg/mL.
double-layer
structures
more
efficient
physiological
saline
environment,
best
fit
following
zero-order
model
(regression
coefficient
R2
=
0.9939).
show
great
potential
applications
medical
industry.
controlled
properties
antibacterial
effectiveness
make
them
promising
carrier
modern
therapies.
Язык: Английский
Hydrogel derived from decellularized pig small intestine submucosa boosted the therapeutic effect of FGF-20 on TNBS-induced colitis in rats via restoring gut mucosal integrity
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101783 - 101783
Опубликована: Апрель 1, 2025
Язык: Английский