Eating disorders and disordered eating symptoms in individuals at clinical high risk for psychosis: a systematic review and meta-analysis DOI Creative Commons
Gabriele Lo Buglio, Marta Mirabella, Laura Muzi

и другие.

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity, Год журнала: 2024, Номер 29(1)

Опубликована: Дек. 27, 2024

Eating disorders (EDs) are among the least studied mental in individuals at clinical high risk for psychosis (CHR-P). The primary aim (a) of this systematic review and meta-analysis was to identify factors predicting ED diagnoses CHR-P individuals. secondary (b) providing a comprehensive description with both EDs/ED-related symptoms. Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) 2020-compliant meta-analysis, searching PubMed/(EBSCO)PsycINFO/Web Science studies published between 01/01/2018 30/05/2023, including EDs/ED symptoms (PROSPERO CRD42023488792). Quality assessment performed using Newcastle–Ottawa Scale (NOS). We meta-regression model on proportion EDs (primary aim) conducted narrative synthesis (secondary aim). included 26 articles, reporting 2,060 589 subjects study (b), respectively (mean NOS score = 6.38). prevalence 0.05 (95% CI 0.3–0.8). No factor had significant effect This result is limited by inability include ED-related antipsychotic prescriptions model, due an insufficient number these variables. offers characterization ED/ED-related symptoms; however, support definitive conclusions. predictor found Transdiagnostic, prospective cohort warranted examine long-term outcomes EDs, beyond diagnostic silos. I.

Язык: Английский

Pathways to prevention: the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program DOI Creative Commons
Barnaby Nelson, Martha E. Shenton, Scott W. Woods

и другие.

Schizophrenia, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample DOI Creative Commons
Stefania Tognin, Sandra Vieira, Dominic Oliver

и другие.

Schizophrenia, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 17, 2025

Abstract Predicting outcomes in individuals at clinical high risk (CHR) of developing psychosis remains challenging using metrics alone. The PSYSCAN project aimed to enhance predictive value by integrating data across clinical, environmental, neuroimaging, cognitive, and peripheral blood biomarkers. employed a naturalistic, prospective design 12 sites (Europe, Australia, Asia, Americas). Assessments were conducted baseline, 3, 6, months, with follow-ups 18 24 months evaluate functional outcomes. study included 238 CHR 134 healthy controls (HC). At HC groups differed significantly age, education, IQ, vocational relationship status. Cannabis tobacco use did not differ between groups, however had higher proportion moderate abuse. A substantial portion the sample met DSM criteria for anxiety (53.4%) and/or mood disorders (52.9%), some prescribed antidepressants (38.7%), antipsychotics (13.9%), or benzodiazepines (16.4%). Over follow-up period, 25 (10.5%) transitioned psychosis. However, group as whole showed improvements functioning attenuated psychotic symptoms. Similar other recent multi-centre studies, cohort exhibits comorbidity rates relatively low transition rates. These findings highlight heterogeneity within populations suggest that extend beyond onset, reinforcing need broader prognostic models consider transdiagnostic

Язык: Английский

Процитировано

0
Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis DOI Creative Commons
Brian P. Keane,

Yonatan Abrham,

Michael W. Cole

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 15, 2024

Abstract People with psychosis exhibit thalamo-cortical hyperconnectivity and cortico-cortical hypoconnectivity sensory networks, however, it remains unclear if this applies to all whether arises from other illness factors, or such differences could form the basis of a viable biomarker. To address foregoing, we harnessed data Human Connectome Early Psychosis Project computed resting-state functional connectivity (RSFC) matrices for 54 healthy controls 105 patients. Primary visual, secondary visual (“visual2”), auditory, somatomotor networks were defined via recent brain network partition. RSFC was determined 718 regions regularized partial correlation. patients— both affective non-affective—exhibited in visual2 but not auditory primary networks. When averaged connections subtracted values, robust biomarker emerged (p=2e-10, Hedges’ g=1.05). This “somato-visual” present antipsychotic-naive patients did depend on confounds as psychiatric comorbidities, substance/nicotine use, stress, anxiety. It had moderate test-retest reliability (ICC=.61) be recovered five-minute scans. The marker discriminate groups leave-one-site-out cross-validation (AUC=.79) improve group classification upon being added well-known neurocognition task. Finally, differentiate later-stage ADHD two independent sets. These results introduce simple that can distinguish by early stages.

Язык: Английский

Процитировано

1
Qualitative Evaluation of Acceptability and Feasibility of a Behavioral Intervention to Reduce Violence Among Young Adults with Early Psychosis DOI
Stephanie A. Rolin, Deirdre Caffrey, Megan G. Flores

и другие.

Community Mental Health Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

Язык: Английский

Процитировано

1
Use of coercive measures in refugees and asylum seekers: a systematic review DOI
Bianca Della Rocca, Mario Luciano,

Rosaria Bello

и другие.

International Review of Psychiatry, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Апрель 2, 2024

Migration process is a well-known risk factor for number of mental disorders, particularly psychotic, trauma-related and major mood disorders. However, refugees asylum seekers (RAS) often face several challenges in accessing health facilities, leading to treatment delays, resulting worse prognosis increased referral the emergency departments or receiving coercive measures, including involuntary hospitalizations psychiatric settings. This review aims delineate prevalence measures within RAS population identify potential predictors such interventions, order highlight possible preventive strategies. The relevant PubMed, Scopus Web Science databases were searched papers. Twenty-three articles included review. Our findings that at higher being coerced compared native due clinical factors, cultural differences many barriers access services. Since are harmful lead outcome (re)traumatization patients, specific strategies prevent this phenomenon urgently needed.

Язык: Английский

Процитировано

0
Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa DOI Creative Commons
Daniel Mamah, Victoria Mutiso, Christine Musyimi

и другие.

Schizophrenia Bulletin Open, Год журнала: 2024, Номер 5(1)

Опубликована: Янв. 1, 2024

The Accelerating Medicines Partnership Schizophrenia (AMP SCZ) funds a longitudinal study of 43 research sites across 5 continents to develop tools stratify developmental trajectories youth at clinical high risk for psychosis (CHR) and identify homogenous targets future trials. However, there are no in Africa, leaving critical gap our knowledge biological outcomes among CHR individuals.

Язык: Английский

Процитировано

0
From palm to practice: prescription digital therapeutics for mental and brain health at the National Institutes of Health DOI Creative Commons

Michele Ferrante,

Layla Esposito,

Luke E. Stoeckel

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Сен. 10, 2024

Prescription Digital Therapeutics (PDTs) are emerging as promising tools for treating and managing mental brain health conditions within the context of daily life. This commentary distinguishes PDTs from other Software Medical Devices (SaMD) explores their integration into treatments. We focus on research programs support National Institutes Health (NIH), discussing PDT supported by NIH's Institute Child Development (NICHD), Mental (NIMH), Aging (NIA). present a hierarchical natural language processing topic analysis NIH-funded digital therapeutics projects. delineate landscape across different disorders while highlighting opportunities challenges. Additionally, we discuss foundation PDTs, unique therapeutic approaches they employ, potential strategies to improve validity, reliability, safety, effectiveness. Finally, address collaborations necessary propel field forward, ultimately enhancing patient care through innovative solutions.

Язык: Английский

Процитировано

0
The Future of Schizophrenia Care: A Lived Experience-Based Call for Innovation DOI
Brandon Staglin

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis DOI
Brian P. Keane,

Yonatan Abrham,

Michael W. Cole

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

0
“Ask” or “Inquire”: operationalizing speech formality in psychosis and its risk states using etymology DOI Creative Commons
Matthew Cotter, Alessia McGowan, Zarina Bilgrami

и другие.

NPP—Digital Psychiatry and Neuroscience, Год журнала: 2024, Номер 2(1)

Опубликована: Окт. 18, 2024

Abstract Many individuals with psychotic symptoms have less complex language than healthy individuals. Word etymology is a lexical feature that has not yet been studied in clinical populations, but among individuals, words of Old French origin are chosen over Germanic-origin to convey formality (e.g. “inquire” vs. “ask”). Differences complexity may relate differences etymological content speech. Here, we determined the proportion word use and Old-French-origin large cohort recent-onset psychosis or at clinically high risk for psychosis, hypothesizing recent onset would increased decreased words. This hypothesis was borne out, even after adjusting sex, age, recruitment site, education, racial identity, subset, IQ. Etymology proportions were associated role social functioning symptoms, consistent premise they reflect speech formality. Understanding spectrum through lens lead new interventions improve functioning.

Язык: Английский

Процитировано

0