Self-reported sleep dysfunction among males deemed a “grave and immediate” risk to others: relationship with reported head injury, executive dysfunction and dynamic risk

Journal of Forensic Practice, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Purpose The link between sleep disturbance and aggression among forensic psychiatric patients is well established. However, the relationship subjective experience of quality hygiene, reported head injury, age, neuropsychological functioning risk within these populations remains poorly understood. A study described examining relationships factors in a sample individuals deemed “grave immediate” toothers. aim this to explore more detail. Design/methodology/approach service evaluation project prevalence self-reported dysfunction, age with functioning, injury dynamic appraisals UK high secure patient ( n = 84). Findings Self-reported poor hygiene present 65% patients, especially those admission dependency wards. Whilst there are no differences history quality, hygiene. Older also report problems. combination performance selective aspects executive tasks has some risk. Practical implications importance management cognitive remediation discussed, as need for robust research inclusion an assessment evaluations. Originality/value To best authors’ knowledge, first examine disturbance, injuries sample.

Язык: Английский

Is muscarinic receptor agonist effective and tolerant for schizophrenia? A systematic review and meta-analysis

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Background: Several randomized clinical trials (RCTs) have recently examined the efficacy and tolerability of muscarinic receptor agonists in schizophrenia. However, whether therapeutics targeting receptors improve symptom management reduce side effects remains systemically unexplored. Methods: Embase, PubMed, Web Science were searched from inception until May 16, 2024. Altogether, safety outcomes four RCTs (397 individuals group, 374 placebo control group) meta-analyzed. To compare scores positive negative syndrome scale (PANSS), response rate, discontinuation adverse events with vs patients schizophrenia, changes pooled as mean difference (MD) for continuous risk ratio (RR) categorical outcomes. Results: It revealed that superior to terms decrease total PANSS score (MD, − 9.92; 95% CI, -12.46 -7.37; I2 = 0%), subscore 3.21; -4.02 -2.40; -1.79; -2.47 -1.11; 48%). According study-defined RR was 2.08 (95% 1.59 2.72; 0%). No significance found rate. Muscarinic associated a higher nausea (RR 4.61, 2.65 8.02; 3%), particular, xanomeline-trospium risks dyspepsia, vomiting, constipation. Conclusions: The findings highlighted an advantage tolerated event profiles

Язык: Английский