Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness

Proceedings of the National Academy of Sciences, Год журнала: 2014, Номер 112(4), С. 1232 - 1237

Опубликована: Дек. 22, 2014

Significance The use of light-emitting electronic devices for reading, communication, and entertainment has greatly increased recently. We found that the these before bedtime prolongs time it takes to fall asleep, delays circadian clock, suppresses levels sleep-promoting hormone melatonin, reduces amount timing REM sleep, alertness following morning. Use immediately also increases at time, which may lead users delay home. Overall, we portable biological effects perpetuate sleep deficiency disrupt rhythms, both can have adverse impacts on performance, health, safety.

Язык: Английский

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Measuring and using light in the melanopsin age

Trends in Neurosciences, Год журнала: 2013, Номер 37(1), С. 1 - 9

Опубликована: Ноя. 25, 2013

•Photoreceptive retinal ganglion cells (ipRGCs) regulate behavior and physiology.•ipRGCs use melanopsin-dependent intrinsic light responses rod/cone inputs.•The relative contribution of each photoreceptor to evoked is not fully understood.•A method for quantifying presented that accounts complex photoreceptive inputs.•Guidance those designing architectural therapeutic lighting provided. Light a potent stimulus regulating circadian, hormonal, behavioral systems. In addition, therapy effective certain affective disorders, sleep problems, circadian rhythm disruption. These biological effects are influenced by distinct in the eye, melanopsin-containing intrinsically photosensitive (ipRGCs), addition conventional rods cones. We summarize neurophysiology this newly described sensory pathway consider implications measurement, production, application light. A new light-measurement strategy taking account inputs these non-visual proposed researchers, simple suggestions artificial/architectural provided regulatory authorities, manufacturers, designers, engineers. During past three decades, empirical evidence has demonstrated many aspects human physiology illumination [1Aschoff J. Biological Rhythms (Handbook Behavioral Neurobiology No. 4). Plenum, 1981Google Scholar, 2Wurtman R.J. et al.The Medical Effects Light. The New York Academy Sciences, 1985Google 3Wetterberg L. Man. Pergamon Press, 1993Google 4Lam R.W. Beyond Seasonal Affective Disorder: Treatment SAD non-SAD Disorders. American Psychiatric 1996Google Scholar]. Such originate eye but separate from other vision insofar as they unrelated particular spatial patterns exposure, can survive even some blind subjects. Consequently, types have been commonly referred non-image-forming or non-visual. catch-all terms encompass wide array response types. most influential light-induced phase resetting endogenous clocks. Because rhythmicity feature nearly every physiological, metabolic, system, phenomenon brings processes under indirect control. this, term come growing list more acute together ensure day-like physiological state. Thus, example, constricts pupil, suppresses pineal melatonin increases heart rate core body temperature, stimulates cortisol acts neurophysiological stimulant (increasing subjective objective measures alertness psychomotor reaction time, reducing lapses attention). Appreciation basic biology led development number applications. shown anti-depressant properties, particularly treatment seasonal disorder (SAD) its subclinical variant sSAD [3Wetterberg Appropriately timed exposure also developed circadian-rhythm disorders disruption associated with jetlag, shift work, space flight. Finally, explored non-seasonal depression, menstrual-cycle-related bulimia nervosa, cognitive fatigue problems senile dementia, chemotherapy, traumatic brain injury 5Tuunainen A. al.Light depression.Cochrane Database Syst. Rev. 2004; 2: 1-83Google 6J. Biol. Rhythms. 2005; 20: 279-386Crossref PubMed Scopus (177) Google on evolved over millennia which environmental reliable indicator time day. advent electrical disrupted relationship, now reflecting personal tastes social pressures. It important therefore incorporated into considerations design. one might ask what extent given replicates natural daylight; how could be employed minimize deleterious shiftwork while promoting safety; optimized. industry academic researchers started address [7CIE Ocular Lighting Human Physiology Behaviour. Commission Internationale de l'Éclairage, 2009Google 8IES Health: An Overview Impact Optical Radiation Visual, Circadian, Neuroendocrine Neurobehavioural Responses. Illuminating Engineering Society North America, 2008Google 9DIN Physics – Part 100: Non-visual Beings Quantities, Symbols Action Spectra. Deutsches Institut fur Normung, Progress endeavors, however, first requires appropriate quantification impacts behavior. There two broad categories measurement techniques: radiometry photometry [10DiLaura D.L. al.Lighting Handbook. Reference Application.10th ed. 2011Google Radiometry based characterizing physical properties wavelength energy. radiometer quantifies radiant power defined bandwidth electromagnetic Photometry specialized branch takes fact photoreceptors equally sensitive at all wavelengths. photometer uses filters weight detector different wavelengths according spectral sensitivity an aspect vision. Most commercially available photometers weighting function termed photopic luminous efficiency (or Vλ), reflects long- middle-wavelength-sensitive cones [11CIE l'Éclairage Proceedings, 1924, Cambridge University Press1926Google Depending geometric interest, intensity (units lumens/sr candelas, cd), luminance (cd/m2), illuminance (lm/m2 lux) determined output devices. Between 1980 2000, great majority studies endocrine, behavioral, quantified stimuli (lux) lux meters were readily inexpensive because tool choice photographic professions. Two related branches investigation since practice inadequate. First, during last decade it was discovered whereas capacity retina dominated cones, few neurons (retinal cells) directly [12Berson D.M. al.Phototransduction set clock.Science. 2002; 295: 1070-1073Crossref (2514) 13Hattar S. al.Melanopsin-containing cells: architecture, projections, photosensitivity.Science. 1065-1070Crossref (1935) achieve through expression melanopsin, opsin photopigment [14Provencio I. al.Melanopsin: melanophores, brain, eye.Proc. Natl. Acad. Sci. U.S.A. 1998; 95: 340-345Crossref (746) 15Provencio al.A novel inner retina.J. Neurosci. 2000; 600-605Crossref 16Lucas al.Diminished pupillary reflex high irradiances melanopsin-knockout mice.Science. 2003; 299: 245-247Crossref (660) ipRGCs comprise only small fraction total cell population (1–5%, depending species estimation), project major retinorecipient parts including [17Ecker J.L. al.Melanopsin-expressing ganglion-cell photoreceptors: cellular diversity role pattern vision.Neuron. 2010; 67: 49-60Abstract Full Text PDF (459) 18Brown T.M. al.Melanopsin contributions irradiance coding thalamo-cortical visual system.PLoS 8: e1000558Crossref (186) 19Gooley J.J. origin retinohypothalamic tract.Nat. 2001; 4: 1165Crossref (443) Specific ablation abolishes responses, identifying class principal conduits photic input systemic [20Goz D. al.Targeted destruction saporin conjugate alters mouse rhythms.PLoS ONE. 2008; 3: e3153Crossref (117) 21Guler A.D. rod-cone vision.Nature. 453: 102-105Crossref (605) 22Hatori M. al.Inducible melanopsin-expressing reveals their central non-image forming responses.PLoS e2451Crossref (212) Furthermore, detect when isolated rest retina, explaining why photosensitivity survives loss functional 23Foster R.G. al.Circadian photoreception retinally degenerate (rd/rd).J. Comp. Physiol. 1991; 169: 39-50Crossref (416) 24Freedman M.S. al.Regulation mammalian non-rod, non-cone, ocular photoreceptors.Science. 1999; 284: 502-504Crossref (639) 25Lucas 505-507Crossref (432) 26Yoshimura T. al.Differences between CBA/J mice (rd/rd) normal CBA/N (+/+).J. 1994; 9: 51-60Crossref (26) 27Keeler C.E. Iris movements mice.Am. 1927; 81: 107-112Crossref 28Czeisler C.A. al.Suppression secretion patients bright light.N. Engl. Med. 1995; 332: 6-11Crossref (523) 29Gooley play roles mediating continuous humans.J. 2012; 32: 14242-14253Crossref (144) This discovery raises possibility fairly rod- cone-based Second, observations indeed very sensitivity. Ten analytic action spectra investigations selected comparisons such humans, non-human primates, rodents revealed peak short-wavelength portion visible spectrum (from 447 484 nm) 30Brainard G. al.Action regulation humans: photoreceptor.J. 21: 6405-6412PubMed 31Thapan K. al.An suppression: non-cone system 535: 261-267Crossref (993) 32Yoshimura Ebihara Spectral phase-shifts rhythms (+/+) mice.J. 1996; 178: 797-802Crossref (118) 33Lucas R. al.Characterization capable driving constriction mice.Nat. 621-626Crossref (495) 34Hankins M.W. Lucas primary humans regulated long-term nonclassical photopigment.Curr. 12: 191-198Abstract (166) 35Hattar systems accessory functions mice.Nature. 424: 75-81Crossref (929) 36Dacey primate signal colour LGN.Nature. 433: 749-754Crossref (981) 37Gamlin P.D. al.Human macaque pupil driven cells.Vision Res. 2007; 47: 946-954Crossref (439) 38Zaidi F.H. al.Short-wavelength pupillary, awareness lacking outer retina.Curr. 17: 2122-2128Abstract (252) 39Lockley S.W. direct alertness, vigilance, waking electroencephalogram humans.Sleep. 2006; 29: 161-168PubMed 40Cajochen C. al.High melatonin, thermoregulation, short light.J. Clin. Endocrinol. Metab. 90: 1311-1316Crossref (632) 41Gooley al.Spectral depend duration light.Sci. Transl. 31ra33Crossref (283) 42Revell V.L. al.Alerting wavelengths.Neurosci. Lett. 399: 96-100Crossref (130) 43Lockley 88: 4502-4505Crossref (588) 44Revell phase-advancing 270-272Crossref (85) 45Brainard G.C. mediated cone system.J. 86: 433-436Crossref (94) Scholar], divergent predicted Vλ (peak 555 nm). Taken together, data demonstrate established photometric function, lux, inadequate intended Unfortunately, date there no replacement. omission practical consequences. For absence suitable agreed makes difficult compare findings replicate experimental conditions. represents significant barrier relating laboratory applications, regulators predict impact regimes fundamental problem addressing need difficulty determining (equivalent Vλ) responses. To understand challenge necessary review ipRGCs. Melanopsin, ipRGCs, structurally phylogenetically closely opsins invertebrate rhabdomeric than rod [46Borges gene duplication unconstrained selective pressures melanopsin family evolution vertebrate regulation.PLoS 7: e52413Crossref (20) 47Nasi E. del Pilar Gomez Melanopsin-mediated light-sensing amphioxus: glimpse microvillar lineage within deuterostomia.Commun. Integr. 2009; 441-443Crossref (13) common rhodopsins, phototransduction cascade engaged results depolarization [48Hughes phototransduction: slowly emerging dark.Prog. Brain 199: 19-40Crossref (67) As result, irradiance-dependent increase firing quantum comparable [49Do M.T. al.Photon capture signalling cells.Nature. 457: 281-287Crossref (214) lack photopigment-concentrating organelles (such segments) maximize probability photon capture. absorbing >1 million times lower area photostimulation though ipRGC amplification much less Once threshold activation reached, scales several decimal orders remarkably persistent, being sustained long durations constant [50Wong K.Y. continuously 10 hours.J. 11478-11485Crossref (108) Although moderate irradiance, downstream responsive levels [51Lucas al.How rod, cone, enlighten clock.Prog. 1-18Crossref (126) originally thought 2500 required suppress nocturnal [52Lewy A.J. humans.Science. 1980; 210: 1267-1269Crossref (1454) later conditions, little 1 [53Glickman al.Ocular regulation: relevance breast cancer.Neuro 23: 17-22PubMed highlights system: receive (Figure 1A) . dendrites targets synaptic bipolar amacrine cells, well sites melanopsin-driven phototransduction. composite, integrated consisting (melanopsin photoreception) incoming cone-driven signals [36Dacey arrangement greatly extends range elicit explains animals genetically null continue exhibit [16Lucas 54Panda (Opn4) requirement shifting.Science. 298: 2213-2216Crossref (672) 55Ruby N.F. al.Role light.Science. 2211-2213Crossref (528) At origin, (ipRGC firing) combined influence multiple processes: mechanism itself, remote 1B). Each mechanisms detection sensitivity, expressed transmission media.(i)Rods. Rod opsin, photoreceptors, shows (λmax) approximately 500 nm species. Pre-receptoral filtering shifts towards somewhat longer standard observer (507 nm).(ii)Cones. Mammalian genomes typically contain genes encoding spectrally opsins. Humans, old world S express short-wavelength-sensitive (cyanolabe), maximally ∼420 nm; M (chlorolabe; ∼535 nm); L red-shifted (erythrolabe; ∼565 [56Stockman Sharpe L.T. sensitivities middle- long-wavelength derived measurements observers known genotype.Vision 40: 1711-1737Crossref (561) Scholar]). Other mammals chlorolabe/erythrolabe distinction, single middle spectrum. differences cyanolabe pigments. rodent retinas near-ultraviolet radiation [57Jacobs G.H. al.Retinal receptors ultraviolet light.Nature. 353: 655-657Crossref (338) pre-receptoral short- medium-wavelength (∼440 545 nm, respectively).(iii)Melanopsin. indicate similarly invariant across species, λmax 480 [58Panda al.Illumination signaling pathway.Science. 307: 600-604Crossref (394) 59Qiu X. al.Induction heterologous melanopsin.Nature. 745-749Crossref (344) 60Koyanagi al.Cephalochordate melanopsin: evolutionary linkage cells.Curr. 15: 1065-1069Abstract (187) 61Torii al.Two isoforms chicken melanopsins show blue sensitivity.FEBS 581: 5327-5331Abstract (65) 62Bailes H.J. forms pigment (λmax ∼479 supporting Gq/11 Gi/o cascades.Proc. 2013; 280: 20122987Crossref (199) potential complication estimate property vivo suggestion like invertebrates, may bistable 63Melyan Z. al.Addition renders photoresponsive.Nature. 741-745Crossref (335) 64Mure L.S. al.Melanopsin-dependent nonvisual responses: bistability vivo.J. 22: 411-424Crossref (131) Bistability affords photopigments regenerate vitamin A-derived chromophore isomerized following absorption another [65Hillman P. al.Transduction bistability.Physiol. 1983; 63: 668-772Crossref (109) regeneration event produced wavelengths, receptor. Whether whether biologically relevant remain [66Mawad Van Gelder R.N. Absence potentiation murine vitro.J. 387-391Crossref (36) 67Rollag M.D. Does consequences?.J. 396-399Crossref (15) 68Papamichael simultaneous presentation red monochromatic 27: 70-78Crossref (31) either event, factor does significantly [69Enezi 'melanopic' predicts polychromatic lights.J. 2011; 26: 314-323Crossref (178) 70Brown melanopic diverse conditions.PLoS e53583Crossref (29) thus five four case non-primates) follows down

Язык: Английский

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Bio-Integrated Wearable Systems: A Comprehensive Review

Chemical Reviews, Год журнала: 2019, Номер 119(8), С. 5461 - 5533

Опубликована: Янв. 28, 2019

Bio-integrated wearable systems can measure a broad range of biophysical, biochemical, and environmental signals to provide critical insights into overall health status quantify human performance. Recent advances in material science, chemical analysis techniques, device designs, assembly methods form the foundations for uniquely differentiated type technology, characterized by noninvasive, intimate integration with soft, curved, time-dynamic surfaces body. This review summarizes latest this emerging field "bio-integrated" technologies comprehensive manner that connects fundamental developments chemistry, engineering sensing have potential widespread deployment societal benefit care. An introduction chemistries materials active components these contextualizes essential design considerations sensors associated platforms appear following sections. The subsequent content highlights most advanced biosensors, classified according their ability capture information. Additional sections feature schemes electrically powering strategies achieving fully integrated, wireless systems. concludes an overview key remaining challenges summary opportunities where chemistry will be critically important continued progress.

Язык: Английский

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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease

Nature reviews. Neuroscience, Год журнала: 2010, Номер 11(8), С. 589 - 599

Опубликована: Июль 14, 2010

Язык: Английский

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Light as a central modulator of circadian rhythms, sleep and affect

Nature reviews. Neuroscience, Год журнала: 2014, Номер 15(7), С. 443 - 454

Опубликована: Июнь 11, 2014

Язык: Английский

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Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance

Journal of Applied Physiology, Год журнала: 2011, Номер 110(5), С. 1432 - 1438

Опубликована: Март 18, 2011

Many people spend an increasing amount of time in front computer screens equipped with light-emitting diodes (LED) a short wavelength (blue range). Thus we investigated the repercussions on melatonin (a marker circadian clock), alertness, and cognitive performance levels 13 young male volunteers under controlled laboratory conditions balanced crossover design. A 5-h evening exposure to white LED-backlit screen more than twice as much 464 nm light emission {irradiance 0,241 Watt/(steradian × m(2)) [W/(sr m(2))], 2.1 10(13) photons/(cm(2) s), range 454 474 nm} non-LED-backlit [irradiance 0,099 W/(sr m(2)), 0.7 nm] elicited significant suppression rise endogenous subjective well objective sleepiness, indexed by reduced incidence slow eye movements EEG low-frequency activity (1-7 Hz) frontal brain regions. Concomitantly, sustained attention, determined GO/NOGO task; working memory/attention, assessed "explicit timing"; declarative memory word-learning paradigm were significantly enhanced compared non-LED condition. Screen quality visual comfort rated same both conditions, whereas tended be considered brighter. Our data indicate that spectral profile emitted impacts physiology, levels. The challenge will design can individually programmed add timed, essential information system humans.

Язык: Английский

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Alerting effects of light

Sleep Medicine Reviews, Год журнала: 2007, Номер 11(6), С. 453 - 464

Опубликована: Ноя. 17, 2007

Язык: Английский

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Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality

Scandinavian Journal of Work Environment & Health, Год журнала: 2008, Номер 34(4), С. 297 - 306

Опубликована: Авг. 1, 2008

Objectives Specifications and standards for lighting installations in occupational settings are based on the spectral sensitivity of classical visual system do not take into account recently discovered melanopsin-based, blue-light-sensitive photoreceptive system. The authors investigated effects exposure to blue-enriched white light during daytime workhours an office setting. Methods experiment was conducted 104 white-collar workers two floors. After baseline assessments under existing conditions, every participant exposed new each lasting 4 weeks. One consisted (17 000 K) other (4000 K). order balanced between Questionnaire rating scales were used assess alertness, mood, sleep quality, performance, mental effort, headache eye strain, mood throughout 8-week intervention. Results Altogether 94 participants [mean age 36.4 (SD 10.2) years] included analysis. Compared with K), improved subjective measures alertness (P<0.0001), positive (P=0.0001), performance evening fatigue irritability (P=0.004), concentration discomfort (P=0.002). Daytime sleepiness reduced quality nocturnal (P=0.016) light. When participants’ expectation about effect treatments entered analysis as a covariate, significant persisted fatigue, irritability, difficulty focusing, concentrating, blurred vision. Conclusions Exposure improves fatigue.

Язык: Английский

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Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

Nature, Год журнала: 2012, Номер 491(7425), С. 594 - 598

Опубликована: Ноя. 1, 2012

Язык: Английский

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Intrinsic Connectivity Networks, Alpha Oscillations, and Tonic Alertness: A Simultaneous Electroencephalography/Functional Magnetic Resonance Imaging Study

Journal of Neuroscience, Год журнала: 2010, Номер 30(30), С. 10243 - 10250

Опубликована: Июль 28, 2010

Trial-by-trial variability in perceptual performance on identical stimuli has been related to spontaneous fluctuations ongoing activity of intrinsic functional connectivity networks (ICNs). In a paradigm requiring sustained vigilance for instance, we previously observed that higher prestimulus cingulo-insular-thalamic network facilitated subsequent perception. Here, test our proposed interpretation this underpins maintenance tonic alertness. We used simultaneous acquisition magnetic resonance imaging (fMRI) and electroencephalography (EEG) the absence any an ensuing hypothesis, namely ICN′s (as measured by fMRI) should show positive correlation with electrical signatures alertness recorded concurrent EEG). found human subjects (19 male, 7 female) comprising dorsal anterior cingulate cortex, insula, prefrontal cortex thalamus is positively correlated global field power (GFP) upper alpha band (10–12 Hz) oscillations, most consistent index Conversely, line earlier findings, was negatively another ICN, so-called attention which prominently involved selective spatial attention. propose serves maintaining through generalized expression cortical oscillations. Attention mediated other systems, e.g., space, selectively disrupts alertness-related suppression hence manifests as local attenuation activity.

Язык: Английский

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