Commercial perspectives: Genome editing as a breeding tool for health and well-being in dairy cattle
JDS Communications,
Год журнала:
2024,
Номер
5(6), С. 767 - 771
Опубликована: Сен. 3, 2024
Genome
editing
is
the
latest
breeding
tool
capable
of
accelerating
rate
genetic
improvement
for
health
and
well-being
traits
in
food
animals.
It
enables
introduction
beneficial
alleles
within
a
single
generation,
including
those
low
frequency
or
absent
population,
while
effectively
bypassing
linkage
drag.
For
dairy
industry,
genome
can
be
used
to
make
rapid
improvements
that
are
precise,
efficient,
transgene-free
functional
not
practically
addressed
without
disrupting
conventional
goals
overall
economic
merit
based
on
genomic
selection.
Herein,
various
case
studies
cattle
presented
demonstrate
applications
enhancing
heat
stress
tolerance,
reduced
disease
susceptibility,
and/or
other
qualitative
some
breeds.
One
highlights
success
simultaneous
multiple
loci
through
recent
advancements
embryonic
stem
cell
biology.
Multiplexed
crucial
addressing
polygenic
nature
inherent
many
economically
important
livestock.
However,
maximizing
benefits
depends
continued
discovery
targets
commercially
important.
Commercialization
also
rapidly
evolving
regulatory
statutes
risk
assessment,
where
countries
already
permit
commercialization
with
non-GMO
alterations
existing
regulations.
New
technologies
like
now
poised
have
significant
impact
equipping
elite
performance
more
resilient
infectious
climate
change
loss
production
gains
obtained
from
decades
Язык: Английский
The future of beef production in South America
Theriogenology,
Год журнала:
2024,
Номер
231, С. 21 - 28
Опубликована: Окт. 8, 2024
Язык: Английский
Allele frequencies of PRLR truncating variants in heat‐tolerant taurine cattle native to Latin America
Animal Genetics,
Год журнала:
2024,
Номер
55(6), С. 910 - 913
Опубликована: Окт. 8, 2024
The
authors
declare
that
there
is
no
conflict
of
interest.
All
relevant
data
are
available
in
the
manuscript
text
and
through
supporting
information.
Tables
S1–S4.
Please
note:
publisher
not
responsible
for
content
or
functionality
any
information
supplied
by
authors.
Any
queries
(other
than
missing
content)
should
be
directed
to
corresponding
author
article.
Язык: Английский
Maintaining Breed Integrity: Successful Introgression of the SLICK1 Allele into the Holstein Breed
Journal of Heredity,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
This
study
evaluated
the
effectiveness
of
genetic
introgression
SLICK1
allele
derived
from
Senepol
cattle
into
Holstein
breed
to
enhance
thermotolerance.
The
allele,
located
in
PRLR
gene,
confers
a
short
and
sleek
coat
that
is
inherited
as
simple
dominant
phenotype.
Approximately
40
years
ago,
University
Florida
initiated
efforts
introgress
this
population.
Here
we
tracked
using
medium-density
genotyping
array
reference
population
both
breeds
(50
Holstein,
46
Senepol).
Among
31
SLICK1+
Holsteins,
there
was
15.25%
±
11.11%
(mean
SD)
ancestry
on
BTA20.
Holsteins
at
descended
slick
matings
did
not
inherit
(n=9)
exhibited
no
ancestry.
A
secondary
genetics
animals
found
BTA4,
spanning
54
markers
15
genes,
with
26.67%
region,
previously
linked
heat
stress
adaptation,
suggests
extends
beyond
incorporate
additional
beneficial
for
thermal
adaptation.
These
findings
indicate
deliberate
enhances
specific
traits
potentially
introduces
other
adaptive
variations.
demonstrates
successful
use
interventions
improve
livestock
resilience
against
environmental
challenges
without
significantly
disrupting
recipient
breed's
structure.
serves
model
breeding
programs
aimed
optimizing
animal
welfare
productivity
face
global
climate
change
while
maintaining
integrity.
Язык: Английский