Single-Cell Transcriptional Response of the Placenta to the Ablation of Caveolin-1: Insights into the Adaptive Regulation of Brain–Placental Axis in Mice

Cells, Год журнала: 2024, Номер 13(3), С. 215 - 215

Опубликована: Янв. 24, 2024

Caveolin-1 (Cav1) is a major plasma membrane protein that plays important functions in cellular metabolism, proliferation, and senescence. Mice lacking Cav1 show abnormal gene expression the fetal brain. Though evidence for placental influence on brain development emerging, whether ablation of affects regulation brain–placental axis remains unexamined. The current study tests hypothesis changes specific cells placenta are linked to deregulation Cav1-null mice. By performing single-nuclei RNA sequencing (snRNA-seq) analyses, we abundance extravillious trophoblast (EVT) stromal cells, but not cytotrophoblast (CTB) or syncytiotrophoblast (STB), significantly impacted due Interestingly, genes related neurogenesis were differentially expressed deletion. Comparison single-cell between further showed such as plexin A1 (Plxna1), phosphatase actin regulator 1 (Phactr1) amyloid precursor-like 2 (Aplp2) EVT STB placenta, also, radial glia ependymal Bulk RNA-seq analysis whole identified similar manner absence Cav1. deconvolution reference cell types from bulk data loss relative neuronal Together, results this suggest causes deregulated

Язык: Английский

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Molecular Regulation of Fetal Brain Development in Inbred and Congenic Mouse Strains Differing in Longevity

Genes, Год журнала: 2024, Номер 15(5), С. 604 - 604

Опубликована: Май 9, 2024

The objective of this study was to investigate gene regulation the developing fetal brain from congenic or inbred mice strains that differed in longevity. Gene expression and alternative splice variants were analyzed a genome-wide manner C57BL/6J (long-lived) comparison B6.Cg-

Язык: Английский

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Relevance of the regulation of the brain-placental axis to the nocturnal bottleneck of mammals

Placenta, Год журнала: 2024, Номер 155, С. 11 - 21

Опубликована: Авг. 6, 2024

Язык: Английский

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