hiPSC-Driven Organoid Construction and Application Prospects DOI Creative Commons
Bangheng Liu, Yulei Mu, Dong‐An Wang

и другие.

Regenerative medicine and dentistry., Год журнала: 2025, Номер unknown, С. 5 - 5

Опубликована: Март 21, 2025

Perspective hiPSC-Driven Organoid Construction and Application Prospects Bangheng Liu 1,2, Yulei Mu 2,3 Dong-An Wang 1,2,* 1 Department of Biomedical Engineering, Chinese University Hong Kong, Sha Tin, New Territories, Kong SAR 999077, China 2 Center for Neuromusculoskeletal Restorative Medicine, InnoHK, HKSTP, 3 City 83 Tat Chee Avenue, Kowloon, * Correspondence: [email protected] Received: 5 March 2025; Revised: 19 Accepted: 20 Published: 21 2025 Abstract: Induced pluripotent stem cell (iPSC)-derived organoid platforms can simulate various target tissues hold broad application prospects in personalized medicine, disease modeling, drug screening, organ transplantation, understanding development mechanisms. Currently, the human iPSC (hiPSC) organoids is gradually shifting towards Matrigel-free scaffold-free systems, promoting precise control over composition structure these systems establishing induction protocols specialized organoids. Researchers are also exploring construction multifunctional with complex structures material exchange channels through vascularization, segmented induction, assembly technologies, though further breakthroughs needed. In future, hiPSC expected to advance precision treatment, high-throughput module detection multi-organ integration, automation. Additionally, when combined large artificial intelligence models, there potential establish data medical platforms, providing support clinical decision-making. Moreover, AI anticipated foster collaboration rather than competition, coordinated growth field. For hiPSC-derived it crucial enhance ethical review framework balance radical scientific exploration conservative public attitudes. must optimize or develop new reduce genomic instability tumorigenic risks, while avoiding emergence non-target cells insufficient functional maturity.

Язык: Английский

Impact of SARS-CoV-2 Variants and Vaccination on Pediatric Febrile Seizures: A Retrospective Cohort Study DOI Creative Commons
Mei Yang,

Y Wang,

Jing Gao

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Abstract Objective This study aimed to investigate the associations between SARS-CoV-2 variants, neuroinflammatory markers, vaccination history, and demographic characteristics in relation occurrence of febrile seizures (FS) pediatric patients at a single tertiary medical center. Methods Retrospective cohort data were collected from care institution April 2020 January 2023, encompassing 339 with PCR-confirmed infections. The was separated into FS (n=102) control (n=237) groups. A multivariable logistic regression analysis employed evaluate impact viral variants (Delta Omicron sublineages), inflammatory markers (IL-6, D-dimer, CRP), status (unvaccinated, partially vaccinated, fully vaccinated), variables, while controlling for potential confounders. Results incidence among infants under one year age found be 41.2%, contrast 17.7% older children (OR=3.2, 95% CI: 1.8–5.7; P<0.001). Elevated levels IL-6 exceeding 10 pg/mL D-dimer surpassing 0.5 mg/L independently associated increased severity (adjusted OR [aOR]=2.8 2.1, respectively), as well 3.1-fold increase risk recurrence. Full linked 68% reduction (aOR=0.32, 0.18–0.55), particularly benefiting infants. Additionally, male exhibited 1.8-fold vulnerability (P=0.016). sublineages (BA.5/XBB), which accounted 78.4% cases, correlated heightened biomarker levels. Conclusion findings suggest that serve valuable indicators assessing infected SARS-CoV-2. protective effect on neural tissues, addition its role reducing transmission, is evident, highlighting susceptibility

Язык: Английский

Процитировано

0
hiPSC-Driven Organoid Construction and Application Prospects DOI Creative Commons
Bangheng Liu, Yulei Mu, Dong‐An Wang

и другие.

Regenerative medicine and dentistry., Год журнала: 2025, Номер unknown, С. 5 - 5

Опубликована: Март 21, 2025

Perspective hiPSC-Driven Organoid Construction and Application Prospects Bangheng Liu 1,2, Yulei Mu 2,3 Dong-An Wang 1,2,* 1 Department of Biomedical Engineering, Chinese University Hong Kong, Sha Tin, New Territories, Kong SAR 999077, China 2 Center for Neuromusculoskeletal Restorative Medicine, InnoHK, HKSTP, 3 City 83 Tat Chee Avenue, Kowloon, * Correspondence: [email protected] Received: 5 March 2025; Revised: 19 Accepted: 20 Published: 21 2025 Abstract: Induced pluripotent stem cell (iPSC)-derived organoid platforms can simulate various target tissues hold broad application prospects in personalized medicine, disease modeling, drug screening, organ transplantation, understanding development mechanisms. Currently, the human iPSC (hiPSC) organoids is gradually shifting towards Matrigel-free scaffold-free systems, promoting precise control over composition structure these systems establishing induction protocols specialized organoids. Researchers are also exploring construction multifunctional with complex structures material exchange channels through vascularization, segmented induction, assembly technologies, though further breakthroughs needed. In future, hiPSC expected to advance precision treatment, high-throughput module detection multi-organ integration, automation. Additionally, when combined large artificial intelligence models, there potential establish data medical platforms, providing support clinical decision-making. Moreover, AI anticipated foster collaboration rather than competition, coordinated growth field. For hiPSC-derived it crucial enhance ethical review framework balance radical scientific exploration conservative public attitudes. must optimize or develop new reduce genomic instability tumorigenic risks, while avoiding emergence non-target cells insufficient functional maturity.

Язык: Английский

Процитировано

0