Efficacy and Safety of Nemolizumab in Patients With Prurigo Nodularis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

This meta-analysis evaluated the efficacy and safety of nemolizumab in treating prurigo nodularis through a systematic review randomized controlled trials. A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, Web Science, identifying relevant studies until January 5th 2025. Four trials involving 859 participants were included final analysis. The primary outcomes assessed itching response measured by Worst Itch Numeric Rating Scale (WI-NRS) Investigator's Global Assessment (IGA) success. Nemolizumab demonstrated significant improvement itch compared to control, with risk ratio 3.52 (95% CI: 2.48 5.02, p < 0.00001) low heterogeneity (I² = 28%). Similarly, IGA success rates notably higher group, 4.40 2.86 6.75, 11%). While adverse events slightly more frequent difference not statistically (RR: 1.11, 95% 0.99 1.24). analysis limited small number trials, relatively short follow-up periods, lack subgroup Despite these limitations, findings suggest that is an effective well-tolerated treatment for nodularis. Further research longer periods larger, diverse patient populations recommended establish long-term profile this condition.

Язык: Английский

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

Translational Vision Science & Technology, Год журнала: 2025, Номер 14(4), С. 12 - 12

Опубликована: Апрель 10, 2025

This study aimed to investigate the mediating role of metabolic biomarkers (MBs) in association between circulating inflammatory proteins (CIPs) and allergic conjunctivitis (AC) identify potential therapeutic targets. A Mendelian randomization (MR) was conducted, leveraging genetic variants as instrumental variables infer causal relationships. Data were obtained from genome-wide studies (GWASs), a two-sample MR employed estimate direct indirect effects CIPs on AC through MBs. Inverse-variance weighting (IVW) served primary analysis method, supplemented by sensitivity analyses assess robustness findings. Six found have significant AC. Natural killer cell receptor 2B4 (CD244) exhibited protective effect, interleukin-18 1 (IL-18R1), IL-6, leukemia inhibitory factor (LIF), protein S100-A12 (EN-RAGE), TNF-related activation-induced cytokine (TRANCE) identified risk factors. The indicated mediation specific MBs these associations, with such 4-oxo-retinoic acid, gulonate, 3-(4-hydroxyphenyl) lactate, S-adenosylhomocysteine, sphingomyelin, significantly influencing pathway highlights crucial These findings offer new insights into pathophysiology suggest targets for novel approaches. underscores targeting approaches modulate pathways implicated

Язык: Английский