The last word on COVID-19 vaccines and breastfeeding? DOI Creative Commons
Andrea Balduit, Roberta Bulla, Chiara Agostinis

и другие.

EBioMedicine, Год журнала: 2023, Номер 97, С. 104830 - 104830

Опубликована: Окт. 12, 2023

More than two years have now elapsed since the COVID-19 vaccination was first authorized and administered worldwide. Over time, evidence on vaccines has been continuously reviewed by regulatory bodies leading to progressive inclusion of even more susceptible groups (i.e., infants, pregnant breastfeeding women). The initial lack consensus, in concert with absence any preliminary data about mRNA vaccine transfer persistence breast milk (BM), determined hesitancy low compliance among mothers. In this issue eBioMedicine, Hanna colleagues attempted put final word biodistribution, fragmentation biological activity BM.1Hanna N. Manzano de Mejia C. Heffes-Doon A. et al.Biodistribution human milk.EBioMedicine. 2023; 96104800https://doi.org/10.1016/j.ebiom.2023.104800Summary Full Text PDF PubMed Scopus (0) Google Scholar They demonstrated that does not persist injection site but can be systemically spread, being mainly packaged into BM extracellular vesicles (EVs). addition, they definitively reported presence BM, although displaying large very little translational activity. Recent scientific literature focused determining functionality anti-Spike protein antibodies vaccinated women,2Rosenberg-Friedman M. Kigel Bahar Y. al.BNT162b2 elicited antibody response blood women.Nat Commun. 2021; 12: 6222Crossref (30) Scholar,3Agostinis Toffoli Balduit al.Anti-spike present SARS-CoV-2 mothers are complement-activating.Int J Mol Sci. 24: 4395Crossref (2) only few studies investigated levels BNT162b2 or mRNA-1273 BM.4Shook L.L. Edlow A.G. Safety efficacy coronavirus disease 2019 (COVID-19) during lactation.Obstet Gynecol. 141: 483-491Crossref (5) Golan al., analyzing 13 samples collected from 7 women 24 h after -including multiple time points, up 48 h, a single participant-have initially neglected vaccine-associated mRNA.5Golan Prahl Cassidy al.Evaluation messenger RNA BTN162b2 milk.JAMA Pediatr. 175: 1069-1071Crossref (35) Low al. instead minimal at sub-picogram level approximately 10% BM: highest concentration detected 2 ng/mL, which would consistent 0.667% original dose 100 mL BM.6Low J.M. Gu Ng M.S.F. al.Codominant IgG IgA expression vaccinees.NPJ Vaccines. 6: 105Crossref (44) Yeo also transient intact 5/309 (2%) samples, serum breastfed infants.7Yeo K.T. Chia W.N. Tan C.W. al.Neutralizing breastmilk lactating women.Front Immunol. 12783975Google It is worthwhile mention limited sample sizes, sensitivity techniques storage may significant impact results these studies. ultimate convincing for precisely study 154 were individuals different intervals and/or booster dose.1Hanna group small amounts 15 post-injection. Interestingly, provided packaging EVs isolated supernatants, as previously anticipated same group,8Hanna Lin X. al.Detection 2022; 176: 1268-1270Crossref (19) approximatively 12–90% found EV fraction. Similar findings paved way proposal new model biodistribution intramuscular injection, lipid nanoparticles enclosing diffuse mammary glands via hematic lymphatic pathways; within cells, developing released BM. surprising researchers working nanoparticles, off-target distribution major formulations last decade.9Carrasco M.J. Alishetty S. Alameh M.G. al.Ionization structural properties influence intravascular administration.Commun Biol. 4: 956Crossref (92) authors moved step further other previous publications field exploring potential integrity mRNA. Assuming EVs, resistant gastric pancreatic digestion retain capability enter intestinal cells vitro,10Liao Du Li J. Lönnerdal B. Human exosomes their microRNAs survive vitro taken cells.Mol Nutr Food Res. 2017; 61https://doi.org/10.1002/mnfr.201700082Crossref (209) decisive breakthrough consists demonstration residual unable induce Spike EV-treated HT-29 cells. This likely due poor it reduced 12–25% duplex droplet digital PCR (ddPCR) using probes targeting flanks vaccine. We like particularly point out had great merit overcoming some technical limitations research, ddPCR linkage assays, use distinct set primers allowed specific sensitive respective mRNAs. should keep mind detection synonymous harm, suggested its scarce benefits maternal lactation mother-infant dyad outweigh conceivable hazards, accordance recommendations governmental health agencies. accumulating evidence, particular emerging current study, allows us reasonably assert danger newborns is, say least, remote; however, safety needed shed light fate BM-derived infant's body provide still controversial issue. Andrea Chiara Agostinis: conceptualization draft preparation. Roberta Bulla: review editing. declare no conflict interest. work supported Italian Ministry Health, through contribution given Institute Maternal Child Health IRCCS Burlo Garofolo-Trieste, Italy.

Язык: Английский

Determinants of perinatal medical care at the ambulatory level in the conditions of the COVID-19 pandemic DOI Creative Commons

V.V. Kaminskiy,

O.I. Zhdanovych, R.M. Savchuk

и другие.

Reproductive health of woman, Год журнала: 2024, Номер 3, С. 10 - 17

Опубликована: Июнь 18, 2024

It is important to determine mothers’ perceptions of health care services during the pandemic ensure equity in provision such future.The objective: determinants pregnant women’s perception perinatal COVID-19 pandemic.Materials and methods. An original sociological study was conducted assess state using a questionnaire. 110 questionnaires were included analysis. Group 1 45 female respondents sick with pregnancy, group 2 – 65 women not pregnancy. All analysed both general sample section pregnancy.Results. Certain shortcomings at ambulatory level identified. Insufficient vaccination coverage (65.5% vaccinated pregnancy). 87.3% patients considered insufficient information about women. A negative attitude towards pregnancy expressed by 30.0% respondents. 65.4% availability conditions pandemic. Remote counseling received less than half (41.8%), mainly those who (62.2%). remote 49.1% More (56.4%) provided COVID-19, treatment prevention be insufficient. Only 9.1% full psychological support. Half satisfied qualifications medical staff, 59.1% staff’s attitude. (55.4%) outpatient stage general, especially did suffer from which may due shift focus attention on infected women.Conclusions. The following positions can recommended improve care: expansion population, particular involvement mass media; conducting explanatory work prevention, vaccination, treatment, possible complications pregnancy; cases; support woman her family all stages care.

Язык: Английский

Процитировано

0
How to Manage a Neonate Born from a SARS-CoV2-Positive Mother: A Narrative Review DOI Creative Commons
Serena Salomè,

Ida D’Acunzo,

F. Fanelli

и другие.

Pathogens, Год журнала: 2024, Номер 13(11), С. 977 - 977

Опубликована: Ноя. 8, 2024

From 2020 to today, considerable knowledge on SARS-CoV-2 has been collected, even pregnant women and their fetuses newborns, clinical guidelines have written implemented worldwide. Vaccination considerably improved outcomes, but hesitancy amongst patients the emergence of variants remain challenging, positivity during pregnancy continues be associated with an increased risk maternal complications, premature delivery, higher neonatal mortality morbidity. A body data now exists effect early medical education in obstetrics pediatrics, longer-term developmental outcomes. This review aimed present important findings outcomes health recommendations for neonate born from a SARS-CoV-2-positive mother order summarize effective preventive healthcare guidelines.

Язык: Английский

Процитировано

0
The last word on COVID-19 vaccines and breastfeeding? DOI Creative Commons
Andrea Balduit, Roberta Bulla, Chiara Agostinis

и другие.

EBioMedicine, Год журнала: 2023, Номер 97, С. 104830 - 104830

Опубликована: Окт. 12, 2023

More than two years have now elapsed since the COVID-19 vaccination was first authorized and administered worldwide. Over time, evidence on vaccines has been continuously reviewed by regulatory bodies leading to progressive inclusion of even more susceptible groups (i.e., infants, pregnant breastfeeding women). The initial lack consensus, in concert with absence any preliminary data about mRNA vaccine transfer persistence breast milk (BM), determined hesitancy low compliance among mothers. In this issue eBioMedicine, Hanna colleagues attempted put final word biodistribution, fragmentation biological activity BM.1Hanna N. Manzano de Mejia C. Heffes-Doon A. et al.Biodistribution human milk.EBioMedicine. 2023; 96104800https://doi.org/10.1016/j.ebiom.2023.104800Summary Full Text PDF PubMed Scopus (0) Google Scholar They demonstrated that does not persist injection site but can be systemically spread, being mainly packaged into BM extracellular vesicles (EVs). addition, they definitively reported presence BM, although displaying large very little translational activity. Recent scientific literature focused determining functionality anti-Spike protein antibodies vaccinated women,2Rosenberg-Friedman M. Kigel Bahar Y. al.BNT162b2 elicited antibody response blood women.Nat Commun. 2021; 12: 6222Crossref (30) Scholar,3Agostinis Toffoli Balduit al.Anti-spike present SARS-CoV-2 mothers are complement-activating.Int J Mol Sci. 24: 4395Crossref (2) only few studies investigated levels BNT162b2 or mRNA-1273 BM.4Shook L.L. Edlow A.G. Safety efficacy coronavirus disease 2019 (COVID-19) during lactation.Obstet Gynecol. 141: 483-491Crossref (5) Golan al., analyzing 13 samples collected from 7 women 24 h after -including multiple time points, up 48 h, a single participant-have initially neglected vaccine-associated mRNA.5Golan Prahl Cassidy al.Evaluation messenger RNA BTN162b2 milk.JAMA Pediatr. 175: 1069-1071Crossref (35) Low al. instead minimal at sub-picogram level approximately 10% BM: highest concentration detected 2 ng/mL, which would consistent 0.667% original dose 100 mL BM.6Low J.M. Gu Ng M.S.F. al.Codominant IgG IgA expression vaccinees.NPJ Vaccines. 6: 105Crossref (44) Yeo also transient intact 5/309 (2%) samples, serum breastfed infants.7Yeo K.T. Chia W.N. Tan C.W. al.Neutralizing breastmilk lactating women.Front Immunol. 12783975Google It is worthwhile mention limited sample sizes, sensitivity techniques storage may significant impact results these studies. ultimate convincing for precisely study 154 were individuals different intervals and/or booster dose.1Hanna group small amounts 15 post-injection. Interestingly, provided packaging EVs isolated supernatants, as previously anticipated same group,8Hanna Lin X. al.Detection 2022; 176: 1268-1270Crossref (19) approximatively 12–90% found EV fraction. Similar findings paved way proposal new model biodistribution intramuscular injection, lipid nanoparticles enclosing diffuse mammary glands via hematic lymphatic pathways; within cells, developing released BM. surprising researchers working nanoparticles, off-target distribution major formulations last decade.9Carrasco M.J. Alishetty S. Alameh M.G. al.Ionization structural properties influence intravascular administration.Commun Biol. 4: 956Crossref (92) authors moved step further other previous publications field exploring potential integrity mRNA. Assuming EVs, resistant gastric pancreatic digestion retain capability enter intestinal cells vitro,10Liao Du Li J. Lönnerdal B. Human exosomes their microRNAs survive vitro taken cells.Mol Nutr Food Res. 2017; 61https://doi.org/10.1002/mnfr.201700082Crossref (209) decisive breakthrough consists demonstration residual unable induce Spike EV-treated HT-29 cells. This likely due poor it reduced 12–25% duplex droplet digital PCR (ddPCR) using probes targeting flanks vaccine. We like particularly point out had great merit overcoming some technical limitations research, ddPCR linkage assays, use distinct set primers allowed specific sensitive respective mRNAs. should keep mind detection synonymous harm, suggested its scarce benefits maternal lactation mother-infant dyad outweigh conceivable hazards, accordance recommendations governmental health agencies. accumulating evidence, particular emerging current study, allows us reasonably assert danger newborns is, say least, remote; however, safety needed shed light fate BM-derived infant's body provide still controversial issue. Andrea Chiara Agostinis: conceptualization draft preparation. Roberta Bulla: review editing. declare no conflict interest. work supported Italian Ministry Health, through contribution given Institute Maternal Child Health IRCCS Burlo Garofolo-Trieste, Italy.

Язык: Английский

Процитировано

0