Oral Isavuconazole Combined with Nebulized Inhalation and Bronchoscopic Administration of Amphotericin B for the Treatment of Pulmonary Mucormycosis: A Case Report and Literature Review DOI Creative Commons
X Leng,

Hui Zhou,

Zhiyang Xu

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(6), С. 388 - 388

Опубликована: Май 29, 2024

Pulmonary mucormycosis (PM) is an invasive and potentially fatal fungal infection, with Rhizopus microsporus (R. microsporus) being the most common pathogen. The routine therapy for this infection includes surgery antifungal agents. However, therapeutic effects of single agents are unsatisfactory due to rapid progression mucormycosis, while not all patients can tolerate surgery. Innovative treatment methods like combination await validations their clinical efficacy. We report a case PM that was diagnosed via metagenomics next-generation sequencing (mNGS) black drainage fluid from patient’s lung. patient eventually recovered discharged after oral isavuconazole, inhaled amphotericin B, local perfusion B through bronchoscopy, which may be promising strategy PM, especially cases where possible. A retrospective study 297 in literature review highlights different used practice.

Язык: Английский

Oral Isavuconazole Combined with Nebulized Inhalation and Bronchoscopic Administration of Amphotericin B for the Treatment of Pulmonary Mucormycosis: A Case Report and Literature Review DOI Creative Commons
X Leng,

Hui Zhou,

Zhiyang Xu

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(6), С. 388 - 388

Опубликована: Май 29, 2024

Pulmonary mucormycosis (PM) is an invasive and potentially fatal fungal infection, with Rhizopus microsporus (R. microsporus) being the most common pathogen. The routine therapy for this infection includes surgery antifungal agents. However, therapeutic effects of single agents are unsatisfactory due to rapid progression mucormycosis, while not all patients can tolerate surgery. Innovative treatment methods like combination await validations their clinical efficacy. We report a case PM that was diagnosed via metagenomics next-generation sequencing (mNGS) black drainage fluid from patient’s lung. patient eventually recovered discharged after oral isavuconazole, inhaled amphotericin B, local perfusion B through bronchoscopy, which may be promising strategy PM, especially cases where possible. A retrospective study 297 in literature review highlights different used practice.

Язык: Английский

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