Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review DOI Creative Commons
Zsófia Gáspár, Blin Nagavci, Bálint Gergely Szabó

и другие.

Microorganisms, Год журнала: 2024, Номер 12(11), С. 2221 - 2221

Опубликована: Ноя. 1, 2024

(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living HIV (PLWH). effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map evidence impact integrase strand transfer inhibitors (INSTI) non-nucleoside reverse transcriptase (NNRTI) PLWH. (2) Methods: A scoping review was conducted using PubMed, Web Science, Embase, reports collected following PRISMA for Scoping Reviews (PRISMA-ScR). (3) Results: Evidence suggests that INSTI-based regimes generally promote restoration alpha diversity, bringing it closer seronegative controls, while beta diversity remains largely unchanged. therapies are suggested be improvements composition tendency toward reduced inflammatory markers. In contrast, NNRTI-based treatments demonstrate limited recovery linked an increase proinflammatory bacteria. (4) Conclusions: Based current literature, is indicated (ART) facilitates better microbiome.

Язык: Английский

Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review DOI Creative Commons
Zsófia Gáspár, Blin Nagavci, Bálint Gergely Szabó

и другие.

Microorganisms, Год журнала: 2024, Номер 12(11), С. 2221 - 2221

Опубликована: Ноя. 1, 2024

(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living HIV (PLWH). effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map evidence impact integrase strand transfer inhibitors (INSTI) non-nucleoside reverse transcriptase (NNRTI) PLWH. (2) Methods: A scoping review was conducted using PubMed, Web Science, Embase, reports collected following PRISMA for Scoping Reviews (PRISMA-ScR). (3) Results: Evidence suggests that INSTI-based regimes generally promote restoration alpha diversity, bringing it closer seronegative controls, while beta diversity remains largely unchanged. therapies are suggested be improvements composition tendency toward reduced inflammatory markers. In contrast, NNRTI-based treatments demonstrate limited recovery linked an increase proinflammatory bacteria. (4) Conclusions: Based current literature, is indicated (ART) facilitates better microbiome.

Язык: Английский

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