Treatment of Long COVID With Enoxaparin

Cardiopulmonary Physical Therapy Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

We read with great attention the case report by Wright et al. They a of Long COVID treated enoxaparin, which significantly improved physical and mental function, including specific symptoms such as PEM orthostatic tachycardia. In this regard, we would like to emphasize that in addition its antithrombotic potential, has other relevant effects could help justify use type patient who usually chronic inflammation acquired thrombophilia favors presence fibrinaloid microclots. These are immunomodulatory—anti-inflammatory antiangiogenic anticomplementemic antitumor antifibrotic potential.1,2 The combinations these potential same drug will probably treat complex pathophysiology surrounds determines multiple reported syndrome. Enoxaparin molecules known have nonanticoagulant fractions, can inhibit T-cell activation, suppressing release inflammatory cytokines mainly IL-4, IL-5, IL-13, TNF-α. Likewise, due high degree sulfation, enoxaparin interact small histamine, proteins heparin binding sites (antithrombin fibronectin), selectins (P L), adhesion (MAC1 PECAM-1), platelet integrin αIIbβ3, complement receptors CR3 CR4, various growth factors (vascular endothelial fibroblast-derived, whose coreceptor on cell surface is heparan sulfate).3,4 All discussed above ensure good therapeutic option; however, it important conduct controlled clinical trials support what was observed report, undoubtedly an incentive search for treatment those affected COVID.

Язык: Английский

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Meaningful Community

Cardiopulmonary Physical Therapy Journal, Год журнала: 2025, Номер 36(2), С. 97 - 97

Опубликована: Март 28, 2025

Язык: Английский

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Answering Our Call to Care: Introduction to the Special Issue on Long Covid

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер 36(1), С. 3 - 5

Опубликована: Дек. 30, 2024

Язык: Английский

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New Year, New Opportunities, New Initiatives

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер 36(1), С. 1 - 2

Опубликована: Дек. 30, 2024

Язык: Английский

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