Neuropathic corneal pain following refractive surgery: risk factors, clinical manifestations, imaging and proteomic characteristics
British Journal of Ophthalmology,
Год журнала:
2025,
Номер
unknown, С. bjo - 325996
Опубликована: Янв. 29, 2025
Background/aims
To
identify
the
risk
factors
for
neuropathic
corneal
pain
(NCP)
following
refractive
surgery
and
to
report
its
clinical
manifestations,
imaging
proteomic
characteristics.
Methods
This
1
year
prospective
cohort
study
included
100
eyes
that
underwent
small
incision
lenticule
extraction
(SMILE)
or
laser-assisted
in
situ
keratomileusis
(LASIK).
Ocular
surface
assessments,
in-vivo
confocal
microscopy
scans,
tear
neuromediators
proteomics
analyses
were
performed.
NCP
was
assessed
using
ocular
assessment
survey.
Univariate
multivariate
conducted
associated
with
postoperative
NCP.
Results
The
incidence
of
13.3%
10.5%
after
SMILE
LASIK,
respectively
(p=0.70).
In
SMILE,
preoperative
manifest
spherical
equivalent
(MRSE)
power
(both
p=0.02)
significantly
higher
compared
non-NCP
group.
had
a
lower
nerve
fibre
length
(CNFL)
(p=0.02),
fractal
dimension
(p=0.003),
width
(p=0.04)
larger
neuroma
area
than
eyes.
MRSE
significant
factor
(95%
CI:
0.48—1.96,
p=0.04).
An
greater
−8.0
diopter
9.57
times
more
likely
develop
(OR=9.57,
p=0.002).
density
CI:0.13—1.11,
p=0.05)
CNFL
CI:0.09—1.25,
Significant
increases
growth
factor,
calcitonin
gene-related
peptide,
Frizzled
class
receptor
7
nucleoside-diphosphate
kinase
three
observed
Conclusions
reported
characteristics
would
patients
susceptible
surgery.
Язык: Английский
Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis
Translational Vision Science & Technology,
Год журнала:
2025,
Номер
14(2), С. 20 - 20
Опубликована: Фев. 18, 2025
The
Ocular
Pain
Assessment
Survey
(OPAS)
has
been
used
to
quantify
chronic
ocular
pain
and
quality
of
life
(QOL).
We
aim
investigate
the
psychometric
properties
individual
OPAS
items
with
Rasch
analysis
in
an
Asian
population
dry
eye
disease
neuropathic
corneal
(NCP).
Question
responses
were
obtained
from
196
patients;
138
(DED)
58
NCP,
at
Singapore
National
Eye
Centre.
Item
hierarchy,
item
fit
statistics,
separation,
reliability
indices,
Yen's
Q3
values
calculated.
Individual
dimensions
that
levels
past
24
hours
QOL
showed
good
discriminative
ability
according
their
person
separation
index
values.
However,
measured
2
weeks,
non-eye
pain,
as
well
aggravating
associated
factors
suboptimal
Significant
correlations
found
between
pairs
dimension
some
dimensions.
Two
questionnaire
validated
analysis.
Based
on
these
findings,
we
shorten
number
questions
improve
performance
tool
similar
populations.
Our
study
provides
insights
existing
for
real-world
clinical
applications
trials.
Язык: Английский