Management of alcohol use disorder: a gastroenterology and hepatology-focused perspective

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Envisioning how to advance the MASH field

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Язык: Английский

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Substance Use Disorders and Interprofessional Management in the Pre and Post Liver Transplant Settings

Clinics in Liver Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Management of alcohol-associated liver disease and alcohol use disorder in liver transplant candidates and recipients: Challenges and opportunities

Liver Transplantation, Год журнала: 2024, Номер 30(8), С. 848 - 861

Опубликована: Март 12, 2024

Alcohol-associated liver disease poses a significant global health burden, with rising alcohol consumption and prevalence of use disorder (AUD) contributing to increased morbidity mortality. This review examines the challenges opportunities in care candidates recipients transplant (LT) AUD. Despite advancements posttransplant patient survival, risk recurrence relapse remains substantial. Several have been identified, including (1) burden alcohol-associated disease, variable practices, systemic barriers; (2) disparities mental therapy access impact on transplant; (3) definitions, underdiagnosis, stigma affecting care; (4) post-LT relapse, its factors, consequential harm. The focuses improve AUD for LT through effective biochemical monitoring, behavioral pharmacologic approaches, creating Centers Excellence care, advocating policy reforms, ensuring insurance coverage necessary services as essential steps toward improving outcomes. also highlights unmet needs, such scarcity addiction specialists, calls further research personalized treatments, digital health, value-based models optimize setting.

Язык: Английский

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Utility of scores to predict alcohol use after liver transplant (lt): take them with a grain of salt

Liver Transplantation, Год журнала: 2024, Номер 30(12), С. 1281 - 1288

Опубликована: Май 22, 2024

The Sustained Alcohol use post-Liver Transplant (SALT) and the High-Risk Relapse (HRAR) scores were developed to predict a return alcohol after liver transplant (LT) for alcohol-associated disease. A retrospective analysis of deceased donor LT from October 2018 April 2022 was performed. All patients underwent careful pre-LT psychosocial evaluation. Data on use, substance abuse, prior rehabilitation, legal issues collected. After LT, all encouraged participate in rehabilitation programs interval phosphatidylethanol testing. Patients with disease stratified by < or > 6 months sobriety before listing. Those <6 further as acute alcoholic hepatitis (AH) NIAAA criteria non-AH. primary outcome utility SALT (<5 vs. ≥5) HRAR (<3 ≥3) (+phosphatidylethanol) within 1 year LT. Of 365 86 had sobriety, 85 sobriety; 41 AH 44 In those AH, mean time abstinence 58 days, 71% failed rehabilitation. Following drinking similar (24%) compared <6-month non-AH (15%) >6-month (22%). Only 4% returned heavy drinking. accuracy both low (accuracy 61%–63%) poor sensitivity (46% 37%), specificity (67%–68%), positive predictive value (22%–26%) moderate negative (81%–83%), respectively higher values (95%) predicting Both good identifying at risk recidivism.

Язык: Английский

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Alcohol-Associated Liver Disease: Managing the Dual Pathology of Liver Disease and of Alcohol Use Disorder

Gastroenterology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Use of Phosphatidylethanol Testing in Patients With Liver Disease

The American Journal of Gastroenterology, Год журнала: 2023, Номер unknown

Опубликована: Окт. 2, 2023

1Division of Gastroenterology and Hepatology, Department Medicine, University Virginia, Charlottesville, USA. Correspondence: Sahil Khanna, MD. E-mail: [email protected].

Язык: Английский

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Pancreatic Panniculitis Mimicking Bilateral Cellulitis: A Case Report

Clinical and Experimental Dermatology, Год журнала: 2024, Номер 49(8), С. 910 - 912

Опубликована: Март 2, 2024

This patient’s case illustrates a unique initial presentation of pancreatic panniculitis mimicking bilateral cellulitis. A novel possible association with semaglutide is discussed.

Язык: Английский

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Positive phosphatidyl-ethanol test in liver disease patients: You can't handle the truth!

Digestive and Liver Disease, Год журнала: 2024, Номер 56(7), С. 1213 - 1214

Опубликована: Март 11, 2024

Язык: Английский

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Clinical Utility and Impact of Phosphatidylethanol Testing in Liver Transplantation Evaluations

Journal of the Academy of Consultation-Liaison Psychiatry, Год журнала: 2023, Номер 65(2), С. 157 - 166

Опубликована: Дек. 1, 2023

Язык: Английский

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