A systematic review of maternal and perinatal health outcomes in the context of epidemic threats: towards the development of a core outcome set. DOI
Agustina Mazzoni, Mabel Berrueta, Magdalena Babinska

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Objective To systematically identify and classify maternal perinatal health outcomes reported in research conducted the epidemic pandemic context. Study design Setting We a systematic review following Cochrane Methods. searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov ICTRP, between January 2015 March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, post-marketing published protocols ongoing registered studies reporting were included. Studies only coverage interventions, access to routine services, clinical presentation infectious diseases, reviews excluded. A sampling strategy was used for COVID-19 due their very high numbers. Outcome verbatims extracted categorized unique outcome, further classified into domains subdomains. Frequency outcome calculated. Results 94 pregnancy 47 neonatal identified, from total 917 657 verbatims, respectively, across 440 included studies. At least 20% mode delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders (26.6%), death (20.7%). These identified all three types (epidemiological, product development or post-authorization surveillance). Gestational age at (29.8%), congenital malformations nervous system (26.1%), weight (23.4%), admission intensive care unit (23.2%), (19.1%) most frequently outcomes. Conclusions Our study provides basis developing core set measure during outbreaks, which would help improve data collection harmonized data, synthesis, timely informed public guidance responding needs pregnant women. .

Язык: Английский

Safety of COVID-19 vaccines during pregnancy: A systematic review and meta-analysis DOI Creative Commons
Agustín Ciapponi, Mabel Berrueta, Edward P K Parker

и другие.

Vaccine, Год журнала: 2023, Номер 41(25), С. 3688 - 3700

Опубликована: Март 27, 2023

Assessment of COVID-19 vaccines safety during pregnancy is urgently needed.

Язык: Английский

Процитировано

46
Safety and Effectiveness of COVID-19 Vaccines During Pregnancy: A Living Systematic Review and Meta-analysis DOI Creative Commons
Agustín Ciapponi, Mabel Berrueta, Fernando Argento

и другие.

Drug Safety, Год журнала: 2024, Номер 47(10), С. 991 - 1010

Опубликована: Июль 15, 2024

Pregnant persons are susceptible to significant complications following COVID-19, even death. However, worldwide COVID-19 vaccination coverage during pregnancy remains suboptimal.

Язык: Английский

Процитировано

6
Immunogenicity of COVID-19 Vaccines During Pregnancy: A Systematic Review and Comparison of Pregnant Versus Nonpregnant Persons DOI
Jamile Ballivian, Edward P K Parker, Mabel Berrueta

и другие.

The Pediatric Infectious Disease Journal, Год журнала: 2025, Номер 44(2S), С. S27 - S31

Опубликована: Фев. 1, 2025

Background: The COVID-19 pandemic induced the rapid deployment of novel vaccines with pregnant persons identified as an at-risk population due to their increased risk severe outcomes. Limited data on immunogenicity in were available at time implementation. To address this gap, we developed a living systematic review summarizing emerging evidence vaccine pregnancy. Methods: Following Cochrane, World Health Organization, and Preferred Reporting Items for Systematic reviews Meta-Analyses guidelines, included studies during We carried out comprehensive biweekly literature searches from March 2022 October 2023, covering multiple databases. Study selection, extraction bias assessment conducted by pairs authors independently. Immunogenicity outcomes, primarily post-vaccination neutralizing or binding antibody concentrations, analyzed descriptively. Post-vaccination ratios versus nonpregnant individuals calculated subset that comparators. Results: By our encompassed 62 predominantly analyzing maternal sera (87%), limited investigation regarding cord, neonatal infant sera. Most investigated mRNA (97%) focused primary vaccination (82%), some investigating booster doses (15%). end points spike-specific IgG (84%) antibodies (24%), T-cell responses (3%). Antibodies detectable after most individuals, similar modestly attenuated concentrations compared (ratios > 0.7 5/6 estimates IgG), albeit modest differences quality kinetics. Long-term antibody-waning trajectories between up 8 months vaccination. Conclusions: induce robust response pregnancy comparable (or attenuated) relative individuals. non-mRNA are notably underrepresented existing literature.

Язык: Английский

Процитировано

0
Safe in pregnancy: A global living systematic review and meta-analysis of COVID-19 vaccines in pregnancy DOI
Pierre Buekens, Mabel Berrueta, Agustín Ciapponi

и другие.

Vaccine, Год журнала: 2024, Номер 42(7), С. 1414 - 1416

Опубликована: Фев. 9, 2024

Язык: Английский

Процитировано

3
A systematic review of maternal and perinatal health outcomes in the context of epidemic threats: towards the development of a core outcome set. DOI
Agustina Mazzoni, Mabel Berrueta, Magdalena Babinska

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Objective To systematically identify and classify maternal perinatal health outcomes reported in research conducted the epidemic pandemic context. Study design Setting We a systematic review following Cochrane Methods. searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov ICTRP, between January 2015 March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, post-marketing published protocols ongoing registered studies reporting were included. Studies only coverage interventions, access to routine services, clinical presentation infectious diseases, reviews excluded. A sampling strategy was used for COVID-19 due their very high numbers. Outcome verbatims extracted categorized unique outcome, further classified into domains subdomains. Frequency outcome calculated. Results 94 pregnancy 47 neonatal identified, from total 917 657 verbatims, respectively, across 440 included studies. At least 20% mode delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders (26.6%), death (20.7%). These identified all three types (epidemiological, product development or post-authorization surveillance). Gestational age at (29.8%), congenital malformations nervous system (26.1%), weight (23.4%), admission intensive care unit (23.2%), (19.1%) most frequently outcomes. Conclusions Our study provides basis developing core set measure during outbreaks, which would help improve data collection harmonized data, synthesis, timely informed public guidance responding needs pregnant women. .

Язык: Английский

Процитировано

0