Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review DOI Open Access
Alexis Trécourt, Marie Donzel,

Nadjla Alsadoun

и другие.

Cancers, Год журнала: 2023, Номер 15(24), С. 5864 - 5864

Опубликована: Дек. 15, 2023

Ovarian sex cord-stromal tumors (SCSTs) account for 8% of all primary ovarian neo-plasms. Accurate diagnosis is crucial since each subtype has a specific prognostic and treatment. Apart from fibrosarcomas, stromal are benign while cord may recur, sometimes with significant time to relapse. Although the based on morphology straightforward, in some cases distinction between be tricky. Indeed, immunophenotype usually nonspecific tumors. Therefore, molecular pathology plays an important role such entities, pathognomonic or recurrent alterations, as FOXL2 variants adult granulosa cell In addition, these neoplasms associated genetic syndromes, Peutz-Jeghers syndrome annular tubules, DICER1 Sertoli-Leydig (SLCTs), which pathologist front line syndromic suspicion. Molecular SCST also relevant patient prognosis management. For instance, variant moderately poorly differentiated SLCTS poorer prognosis. The present review summarizes histomolecular criteria useful SCST, using recent data literature.

Язык: Английский

Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review DOI Open Access
Alexis Trécourt, Marie Donzel,

Nadjla Alsadoun

и другие.

Cancers, Год журнала: 2023, Номер 15(24), С. 5864 - 5864

Опубликована: Дек. 15, 2023

Ovarian sex cord-stromal tumors (SCSTs) account for 8% of all primary ovarian neo-plasms. Accurate diagnosis is crucial since each subtype has a specific prognostic and treatment. Apart from fibrosarcomas, stromal are benign while cord may recur, sometimes with significant time to relapse. Although the based on morphology straightforward, in some cases distinction between be tricky. Indeed, immunophenotype usually nonspecific tumors. Therefore, molecular pathology plays an important role such entities, pathognomonic or recurrent alterations, as FOXL2 variants adult granulosa cell In addition, these neoplasms associated genetic syndromes, Peutz-Jeghers syndrome annular tubules, DICER1 Sertoli-Leydig (SLCTs), which pathologist front line syndromic suspicion. Molecular SCST also relevant patient prognosis management. For instance, variant moderately poorly differentiated SLCTS poorer prognosis. The present review summarizes histomolecular criteria useful SCST, using recent data literature.

Язык: Английский

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