Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022
BMJ Public Health,
Год журнала:
2025,
Номер
3(1), С. e001307 - e001307
Опубликована: Янв. 1, 2025
Background
Knowledge,
attitude
and
practices
(KAP)
towards
COVID-19
can
directly
impact
healthcare
workers’
(HCWs)
services
efforts
to
contain
the
spread
of
disease.
This
study
assessed
KAP
among
HCWs
(laboratorians,
doctors,
nurses
pharmacists)
in
Nigeria
from
August
December
2022.
Method
A
facility-based
cross-sectional
was
conducted
on
1341
7
facilities
across
3
states
Nigeria.
were
selected
using
a
stratified
random
sampling
technique.
structured
questionnaire
including
sociodemographic
health
information,
sections
administered
participants.
Using
Bloom’s
cut-off,
percentages
correct
responses
questions
grouped
as
either
satisfactory
(≥80%)
or
unsatisfactory
(<80%).
Binary
logistic
regression
used
determine
association
between
HCWs’
cadre
KAP.
Results
The
proportions
HCW
with
64.5%,
51.2%
5.3%,
respectively.
Laboratorians
had
lowest
scores
(59.4%,
45.9%
2.0%).
There
weak
linear
relationship
knowledge
practice
(r=0.1,
p:0.03),
(r=0.2,
p<0.001),
(r=0.20,
p<0.001).
6–10
years
increased
odds
(p=0.049).
not
significantly
associated
(P>.05).
However,
compared
laboratorians
higher
(p:0.033).
Socio-demographic
factors
age
group,
gender,
marital
status,
vaccination
(p<.05).
Satisfactory
status
Conclusion
are
gaps
prevention
Additional
exploration
is
needed
understand
challenges
implementing
safety
protocols
cadres,
particularly
laboratorians,
better
handle
future
emergencies.
highlights
implementation
strategies
that
include
education
training,
provision
personal
protective
equipment
clear
guidelines
for
infection
control
practices.
Язык: Английский
Soluble platelet selectin and platelets in COVID-19: a multifaceted connection
Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
86(8), С. 4634 - 4642
Опубликована: Июнь 19, 2024
The
COVID-19
pandemic
has
brought
to
light
the
intricate
relationship
between
platelets,
soluble
platelet
selectin
(sP-selectin),
and
disease
pathogenesis.
Platelets,
traditionally
recognized
for
their
role
in
hemostasis,
have
emerged
as
key
contributors
immunothrombotic
complications
observed
patients.
Concurrently,
elevated
levels
of
sP-selectin,
indicative
activation
endothelial
injury,
been
consistently
identified
patients
shown
associations
with
severity
adverse
outcomes.
This
multifaceted
connection
underscores
pivotal
platelets
sP-selectin
orchestrating
thromboinflammation,
vascular
dysfunction,
progression
COVID-19.
Platelet
triggers
release
inflammatory
mediators
promotes
platelet-leukocyte
interactions,
amplifying
systemic
response
exacerbating
injury.
Additionally,
platelet-derived
factors
contribute
microvascular
thrombosis,
further
tissue
damage
organ
dysfunction
severe
Elevated
serve
biomarkers
prognostication,
aiding
risk
stratification
early
identification
at
higher
Therapeutic
strategies
targeting
sP-selectin-mediated
pathways
hold
promise
mitigating
thromboinflammation
improving
outcomes
Antiplatelet
agents,
inhibitors,
anti-inflammatory
therapies
represent
potential
interventions
attenuate
activation,
inhibit
alleviate
dysfunction.
A
comprehensive
understanding
pathogenesis
offers
opportunities
tailored
therapeutic
approaches
aimed
patient
this
complex
challenging
clinical
setting.
Язык: Английский
The dynamic role of soluble urokinase plasminogen activator receptor (suPAR) in monitoring coagulation dysfunction during COVID-19 progression: a review
Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
87(2), С. 635 - 640
Опубликована: Дек. 11, 2024
COVID-19,
caused
by
the
severe
acute
respiratory
syndrome
coronavirus
2,
has
led
to
significant
morbidity
and
mortality
worldwide,
with
complications
often
involving
coagulation
dysfunction
thromboembolic
events.
Identifying
reliable
biomarkers
for
early
detection
monitoring
of
these
is
crucial
improving
patient
outcomes.
The
soluble
urokinase
plasminogen
activator
receptor
(suPAR)
emerged
as
a
potential
biomarker
in
this
context,
given
its
role
inflammation
immune
response.
Elevated
suPAR
levels
correlate
disease
severity
inflammatory
markers,
making
it
valuable
indicator
complex
interplay
between
observed
COVID-19.
have
been
linked
an
increased
risk
events,
such
deep
vein
thrombosis
pulmonary
embolism.
Combining
measurement
other
D-dimer,
enhances
predictive
accuracy
thrombotic
complications.
Furthermore,
higher
are
associated
severity,
intensive
care
requirements,
rates,
underscoring
significance
stratification
therapeutic
decision-making.
integration
into
routine
clinical
practice
COVID-19
could
significantly
aid
diagnosis,
assessment,
interventions.
By
providing
insights
patient's
status,
can
guide
timely
initiation
anticoagulant
therapy
treatments
aimed
at
reducing
As
research
continues
validate
suPAR's
utility
across
diverse
populations
settings,
holds
promise
becoming
integral
component
management
strategies
mitigate
Язык: Английский