Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis

Endocrinology Diabetes & Metabolism, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 1, 2025

ABSTRACT Objective Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. There inconsistency between previous studies regarding blood and inflammatory parameters levels among pregnant women its association with GDM. This study aimed to investigate relationship in relation Methods Systematic literature searches were carried out through databases like PubMed, Web Science, Epistemonikos, Scopus, Scientific Information Database Magiran till May 2024. The effect size serum was determined by using standard mean deviations (SMDs) 95% confidence intervals (CIs). Results Thirty articles included this study. Meta‐analysis showed that compared control group, GDM had significantly higher haemoglobin (0.343 [95% CI 0.134–0.553] p = 0.01, sensitivity analysis: 0.174 0.0343–0.315] 0.01), red cell (0.387 0.224–0.550] < 0.001), platelet volume (0.498 0.165–0.831] 0.003), white count (0.351 0.0882–0.615] 0.009) neutrophil–lymphocyte ratio (0.534 0.127–0.941] 0.01). However, lower corpuscular concentration (−0.249 −0.386–−0.112] 0.001). Pooled results from MPV no adjusted (adjusted OR 1.33 0.8–1.86] I 2 57.2%). Conclusions Finding supports (Hb, RBC, WBC, NLR MPV) second trimester Future should potential role these haematological markers as predictive tools for adverse pregnancy outcomes evaluate therapeutic interventions targeting enhance maternal fetal health.

Язык: Английский

---

Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study

Antioxidants, Год журнала: 2024, Номер 13(4), С. 480 - 480

Опубликована: Апрель 17, 2024

The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) characterized by the excessive accumulation of fat in liver.

Язык: Английский

---

Nrf2 activators for the treatment of rare iron overload diseases: from bench to bedside

Redox Biology, Год журнала: 2025, Номер 81, С. 103551 - 103551

Опубликована: Фев. 14, 2025

Iron overload and related oxidative damage are seen in many rare diseases, due to mutation of iron homeostasis-related genes. As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic levels by regulating iron-related genes pathways, making activators very good candidates for the treatment disorders. Successful examples include clinical use omaveloxolone Friedreich's Ataxia dimethyl fumarate relapsing-remitting multiple sclerosis. Despite these uses, therapeutic potentials disorders may be overlooked practice. Therefore, this study talks about potential use, possible mechanisms, precautions treating diseases. In addition, combination therapy with chelators is proposed reference, aiming facilitate more

Язык: Английский

---

Research Progress on the Association between Obesity and Intracranial Atherosclerotic Stenosis

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 520 - 529

Опубликована: Янв. 1, 2025

Язык: Английский

---

Dietary Antioxidants and Natural Compounds in Preventing Thrombosis and Cardiovascular Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11457 - 11457

Опубликована: Окт. 25, 2024

Reactive oxygen species (ROS) contribute to endothelial dysfunction, platelet activation, and coagulation abnormalities, promoting thrombus formation. Given the growing interest in non-pharmacological approaches modulate oxidative stress, we examine potential of various dietary interventions antioxidant supplementation reducing damage preventing thrombotic events. Key patterns, such as Mediterranean, Dietary Approaches Stop Hypertension (DASH), ketogenic diets, well antioxidant-rich supplements like curcumin, selenium, polyphenols, demonstrate promising effects improving stress markers, lipid profiles, inflammatory responses. This review highlights recent advances field, drawing from vitro, ex vivo, clinical studies, underscores importance integrating strategies into preventive therapeutic for managing thrombosis cardiovascular health. Further research is needed better understand long-term personalize these optimizing patient outcomes.

Язык: Английский

---

Comparative analysis of non-fermented and Saccharomyces boulardii-fermented whey: Peptidomic profiling, in silico bioactive peptide analysis, and in vivo evaluation of serum proteins and immune response

International Dairy Journal, Год журнала: 2025, Номер unknown, С. 106222 - 106222

Опубликована: Фев. 1, 2025

Язык: Английский

---

The Usefulness of the Glucose Management Indicator in Evaluating the Quality of Glycemic Control in Patients with Type 1 Diabetes Using Continuous Glucose Monitoring Sensors: A Cross-Sectional, Multicenter Study

Biosensors, Год журнала: 2025, Номер 15(3), С. 190 - 190

Опубликована: Март 16, 2025

The Glucose Management Indicator (GMI) is a biomarker of glycemic control which estimates hemoglobin A1c (HbA1c) based on the average glycemia recorded by continuous glucose monitoring sensors (CGMS). GMI provides an immediate overview patient’s control, but it might be biased sensor wear adherence or sensor’s reading errors. This study aims to evaluate GMI’s performance in assessment and identify factors leading erroneous estimates. In this study, 147 patients with type 1 diabetes, users CGMS, were enrolled. Their was extracted from report HbA1c measured at certified laboratories. median value overestimated 0.1 percentage points (p = 0.007). measurements had good reliability, demonstrated Cronbach’s alpha index 0.74, inter-item correlation coefficient 0.683 covariance between 0.813. difference reversely associated (Spearman’s r −0.707; p < 0.001). reliable tool evaluating diabetes. It tends underestimate high values, while overestimate low HbA1c.

Язык: Английский

---

Garden Cress Seed: A Review of Its Functional and Medicinal Properties

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101894 - 101894

Опубликована: Апрель 1, 2025

Язык: Английский

---

Human serum albumin or polyvinyl alcohol can only partially replace human plasma during in vitro red cell production from PBMC

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 8, 2025

Язык: Английский

---

Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4258 - 4258

Опубликована: Июль 21, 2024

Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need understand how these factors interact influence risk outcomes. We aim elucidate roles dysregulated adipokines in obesity, impact gut microbiota disruptions, neuroinflammatory cascade initiated lipopolysaccharides (LPS) AIS. Dysregulated obesity exacerbate inflammatory responses, increasing severity. Disruptions subsequent LPS-induced neuroinflammation further link Advances neuroimaging biomarker development have improved diagnostic precision. Here, we highlight for approach management, integrating metabolic, microbiota, insights. Potential therapeutic strategies targeting pathways could significantly improve prevention treatment. Future research should focus on elucidating developing targeted interventions mitigate impacts metabolic imbalances,

Язык: Английский

---