Physicochemical Characteristics of Cardiological Drugs and Practical Recommendations for Intravenous Administration: A Systematic Review

Scientia Pharmaceutica, Год журнала: 2025, Номер 93(1), С. 13 - 13

Опубликована: Март 12, 2025

Most cardiological drugs need intravenous administration to have a fast effect in an emergency. Intravenous is linked complications, such as tissue infiltration and thrombophlebitis. Aiming supply effective tool for the development of appropriate policies, this systematic review provides practical recommendations about diluent, pH, osmolarity, dosage, vesicant properties, phlebitis rate most commonly used evaluated randomized controlled trials (RCTs) till 31 August 2024. The authors searched available IV RCTs PUBMED EMBASE®, EBSCO-CINAHL®, Cochrane Controlled Clinical trials. Drugs’ chemical features were obtained online, drug data sheets, scientific papers, establishing that with pH <5 or >9, osmolarity > 600 mOsm/L, high incidence reported literature, well drugs, require utmost caution during administration. A total 857 papers 316 studies included. 84 identified, which only (37%) can be safely infused via peripheral route. Thrombolytics anticoagulants are considered safest classes one flagged “red flag” medication. However, higher percentage other categories meet criteria, including antiarrhythmics (52%), antiplatelet agents (67%), diuretics antihypertensives (70%), (77%), vasoconstrictors inotropics (89%). Understanding physicochemical properties essential significantly improving patient safety preventing errors local side effects.

Язык: Английский

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Vascular access device selection

Nursing, Год журнала: 2024, Номер 54(9), С. 25 - 37

Опубликована: Авг. 23, 2024

A systematic evaluation of vascular access device (VAD) selection incorporates patient, device, and infusate characteristics to ensure optimal placement. This article explores VAD from the perspective vessel health preservation describes options indications, VAD-related complications, strategies reduce those complications.

Язык: Английский

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Optimizing peripheral I.V. access outcomes – Part 2

Nursing, Год журнала: 2024, Номер 54(10), С. 19 - 29

Опубликована: Сен. 20, 2024

Abstract: Peripheral I.V. access failure is a source of patient discomfort and dissatisfaction with significant financial impact on healthcare. This article reviews the benefits risks peripheral catheter (PIVC) utilization, infusate characteristics their vasculature, PIVC site assessment management, research priorities. Part 1 this series was published in Nursing's September 2024 issue.

Язык: Английский

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